Reviewed, UniProtKB/Swiss-Prot Q86B87 (MMD4_DROME)

Names and origin

Protein names

Recommended name:
    Modifier of mdg4

Gene names

Name:	mod(mdg4)
Synonyms:	bpd, doom, E(var)3-93D
ORF Names:	CG32491

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways. Ref.1 Ref.2 Ref.3 Ref.4 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.17 Ref.18 Ref.21
Subunit structure	Can self-associate. Isoform mod2.2 is a component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw). Isoform mod2.2 also interacts with Trl/GAGA and interaction with this protein may bypass the repressive effects of the su(Hw) insulator. Interacts with Chi. Ref.2 Ref.18 Ref.16 Ref.19 Ref.20 Ref.22
Subcellular location	Nucleus. Note: Colocalizes with other elements of the gypsy chromatin insulator complex at multiple sites on polytene chromosomes and at nuclear insulator bodies. The unique C-termini of individual isoforms may specify binding to particular chromosomal locations. During the G2 phase of male meiosis isoform H localizes to the nucleolus. It subsequently localizes to the rDNA repeats of the X-Y bivalent and to multiple autosomal loci, where it remains until anaphase I. Localization to the rDNA repeats requires SA-2, while localization to autosomal loci requires SA-2 and tef. Ref.1 Ref.4 Ref.12 Ref.21 Ref.16 Ref.19 Ref.22 Ref.14
Developmental stage	Expressed both maternally and zygotically. Zygotic expression is high in pupae and adult females but low in other stages of development. Ref.4
Domain	Homotypic interactions mediated by the BTB (POZ) domain of this protein may promote the clustering of distant insulator complexes into nuclear insulator bodies.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 1 FLYWCH-type zinc finger.
Sequence caution	The sequence AAA82990.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. The sequence AAL29128.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Chromatin regulator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW germ cell migration Ref.15 Inferred from genetic interaction. Source: FlyBase induction of apoptosis Ref.3 Inferred from mutant phenotype. Source: UniProtKB male meiosis I Inferred from mutant phenotype. Source: FlyBase male meiosis chromosome segregation Inferred from mutant phenotype. Source: FlyBase nucleus organization Traceable author statement. Source: FlyBase oogenesis Ref.4 Inferred from mutant phenotype. Source: FlyBase regulation of chromatin assembly or disassembly Ref.2 Inferred from mutant phenotype. Source: UniProtKB regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromatin Ref.2 Inferred from mutant phenotype. Source: UniProtKB nucleus Ref.4 Inferred from direct assay. Source: FlyBase polytene chromosome Ref.4 Inferred from direct assay. Source: FlyBase
Molecular function	SUMO binding Inferred from physical interaction. Source: FlyBase chromatin binding Ref.2 Inferred from mutant phenotype. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8SXX8	1	EBI-124784,EBI-103476
	Q9W2M4	1	EBI-124784,EBI-138493
CG10265	Q9V786	1	EBI-124784,EBI-167512
Dox-A2	P25161	1	EBI-124784,EBI-169750
mago	P49028	1	EBI-124784,EBI-159609
yellow-d2	Q9W1R0	1	EBI-124784,EBI-166707

Alternative products

This entry describes 31 isoforms produced by alternative splicing. [Align] [Select]
Isoform mod2.2 Ref.4 (identifier: Q86B87-1) Also known as: 67.2; E(VAR)3-93D; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 53.1 (identifier: Q86B87-16) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GDATQFFFTK...KDRGRASQRM
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 53.6 (identifier: Q86B87-28) The sequence of this isoform differs from the canonical sequence as follows:      404-610: ATSASATKIP...LQKALQNKKK → CYQLVPNRRG...RCRKRPGDRK
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 54.7 (identifier: Q86B87-23) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → EQEDDFKLHL...SALSGLHNHP
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 55.6 (identifier: Q86B87-13) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GHLSTLRHLP...HNHPPKKRRL
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 59.0 (identifier: Q86B87-25) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VTQHVRNCGP...EGNPDHLPKM
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform 62.3 (identifier: Q86B87-4) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → ESSVAIYSAT...GGTRVVSRRK
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Isoform A Ref.5 (identifier: Q86B87-17) Also known as: 54.2; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → EKQFEYVVSQ...QYMKLQLNNV
Isoform AA (identifier: Q86B87-29) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VLTYDDRGKL...CPPRPHKEDY
Note: No experimental confirmation available.
Isoform AC (identifier: Q86B87-30) The sequence of this isoform differs from the canonical sequence as follows:      404-610: ATSASATKIP...LQKALQNKKK → FHIDFADSKK...IKSKLRNQDF
Note: No experimental confirmation available.
Isoform AB (identifier: Q86B87-31) The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GVIQSLKALF...DLLDEFPELQ
Note: No experimental confirmation available.
Isoform B (identifier: Q86B87-27) Also known as: 54.6; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VTFDVLTDPI...YAVSGVHNHP
Note: No experimental confirmation available.
Isoform C Ref.1 Ref.4 (identifier: Q86B87-9) Also known as: 58.0; 3; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → DGPSKDTAIP...LKLMPIKEGK
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	422	1	V → A in CAA53215. Ref.1
Isoform D (identifier: Q86B87-24) Also known as: 57.4; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → EFDYGHGQYR...PQSMAHMFDM
Isoform E Ref.4 (identifier: Q86B87-2) Also known as: 65.0; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VKIKMEPSPT...HGAVFISKDY
Isoform F Ref.4 (identifier: Q86B87-8) Also known as: 58.6; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VVLANDEVPN...EELNELTHDV
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	521	1	S → T in CAB85480. Ref.4
Isoform G Ref.4 (identifier: Q86B87-15) Also known as: 54.2; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → ELAVFGTGQR...REKALSLDAS
Isoform H Ref.3 Ref.4 (identifier: Q86B87-10) Also known as: 56.3; Doom; MNM; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → DLGELNPSNL...VAISGVHNHL
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	447	1	D → A in CAB85478. Ref.4
Isoform I Ref.4 (identifier: Q86B87-6) Also known as: 59.1; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → VCDDLDDMKG...LSIEDLNNLQ
Isoform J Ref.4 (identifier: Q86B87-19) Also known as: 51.4; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GSVAYYSYIT...KCGQHNHPPY
Isoform K Ref.4 (identifier: Q86B87-11) Also known as: 55.7; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GQFIGDIPRG...MPKDAFYPQY
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	484	1	A → P in CAB85477. Ref.4
Isoform L Ref.5 (identifier: Q86B87-18) Also known as: 52.2; The sequence of this isoform differs from the canonical sequence as follows:      404-610: ATSASATKIP...LQKALQNKKK → KDQNKGVLLK...EHAQHCLQCY
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	469	1	A → T in CAC51387. Ref.5
Isoform M (identifier: Q86B87-14) Also known as: 55.3; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → DRKRYSKKFL...SLKMPWVFTD
Isoform N Ref.4 (identifier: Q86B87-3) Also known as: 64.2; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → DTEISFIRSQ...HRSLLKSEHP
Isoform O Ref.4 (identifier: Q86B87-5) Also known as: 60.1; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → EDELVFIESP...MHASMMLMHE
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	543	1	M → I in CAB85483. Ref.4
Isoform P Ref.6 (identifier: Q86B87-7) Also known as: 58.6; The sequence of this isoform differs from the canonical sequence as follows:      404-610: ATSASATKIP...LQKALQNKKK → KFDYQISVDV...AATSAPATTT
Isoform Q Ref.4 (identifier: Q86B87-21) Also known as: 46.3; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GCDGLQGSCRDRGGQKLTGANHQMHLRA
Isoform R Ref.4 (identifier: Q86B87-20) Also known as: 52.0; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GTSHLATFSC...RLKYAKHSHL
Isoform S Ref.4 (identifier: Q86B87-12) Also known as: 55.1; The sequence of this isoform differs from the canonical sequence as follows:      403-610: AATSASATKI...LQKALQNKKK → GLIFKAARHI...CEPCFEELHS
Isoform mod1.8 (identifier: Q86B87-26) The sequence of this isoform differs from the canonical sequence as follows:      459-610: GVKLIFNGHL...LQKALQNKKK → DPTRPQLWSS...ILPTQTFVFC
Isoform mod1.9 (identifier: Q86B87-22) The sequence of this isoform differs from the canonical sequence as follows:      360-449: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	Modifier of mdg4		PRO_0000096505
Regions
	Domain	32 – 98	67	BTB
	Zinc finger	452 – 512	61	FLYWCH-type
	Region	1 – 308	308	Interaction with Chi
	Region	1 – 160	160	Self-association
	Region	551 – 610	60	Interaction with su(Hw)
	Compositional bias	139 – 209	71	Gln-rich
Amino acid modifications
	Modified residue	230	1	Phosphoserine Ref.23
Natural variations
	Alternative sequence	360 – 449	90	Missing in isoform mod1.9.		VSP_010283
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GDATQFFFTKGQRESVKLNY CGHSYVKFMENGRGTKWICA TRSTTKCRARIRTTKNNYLE VLYASHNHGFPPQKKDRGRA SQRM in isoform 53.1. Ref.1 Ref.3 Ref.4 Ref.5		VSP_050724
	Alternative sequence	403 – 610	208	AATSA…QNKKK → EQEDDFKLHLPLLVTRRKKT PGGSRKQSFDHLEVSFTRSN RGNNLLTIDGKPFTLDRRIK DVCYWECVKLRCKYIKCSAR VVTKSNRISALSGLHNHP in isoform 54.7.		VSP_010287
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GHLSTLRHLPVEAIFDADGK QMDFIPNIRVIRSQRKTIKL MFKKYAYSKTNEHDTTTYWH CRSRRNGRPACKARFSTKKL KNGSYKVYLTQPEHNHPPKK RRL in isoform 55.6.		VSP_050725
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VTQHVRNCGPQMFLISRKGG TLLTINNFVYRSNLKFFGKS NNILYWECVQNRSVKCRSRL KTIGDDLYVTNDVHNHMGDN KRIEAAKAAGMLIHKKLSSL TAADKIQGSWKMDTEGNPDH LPKM in isoform 59.0.		VSP_010288
	Alternative sequence	403 – 610	208	AATSA…QNKKK → ESSVAIYSATSRGRMQLIYG GQPFIFEKTLKLSSGEEKRF WRCNQWWNQKCRSRVFTIND VVCPLNRFHTHEEIVRRKKR VRRVPPVETIAKVVATTPRH PQHQQTTQQQQEIQLTSDAI AGAILDDESPATIDVSELGM HLKYEEIVADVTGIVGGTRV VSRRK in isoform 62.3.		VSP_050701
	Alternative sequence	403 – 610	208	AATSA…QNKKK → EKQFEYVVSQKGHVLLLHKK FPFIREKCINGKTYWRCTQY TTKTKCHGRLHVLNGKIVHI KTHNHSPLDQERKQYMKLQL NNV in isoform A.		VSP_050713
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VLTYDDRGKLVHEGFTFSCY SRNPGKCLAFWRCSMYKKMH CTSALTTHIKSIKSIRGFHN HKPPERLKTFVPRVLDCPPR PHKEDY in isoform AA.		VSP_034704
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GVIQSLKALFEGKTTGASIQ YTTTQRGRVMLVYEGYRYVV NRQSLKNVFWRCSRYVKHSC RATLVTSKVQEVTLRIAGTP HTHAPEVSSMDLTTDLLDEF PELQ in isoform AB.		VSP_034705
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VTFDVLTDPIVKPDQHQLMK RVRLSKSMEGVHYVRTPAGN VVLHCGEHRYLRNAAYKDKV YWKCSKWRKQCRSRVITHIL PNGQSRYAVSGVHNHP in isoform B.		VSP_010284
	Alternative sequence	403 – 610	208	AATSA…QNKKK → DGPSKDTAIPKPAEHPRKPV TDSVQKSPRDADAIPLFDGS RVFVSKVALAKAYIPMPMIY TCRVMDLVIGKDKLVRIAQH EETTDKDLIQDIITHVCKVF ALRGNQLTPSAVQEFIDHKL STLKLMPIKEGK in isoform C.		VSP_050714
	Alternative sequence	403 – 610	208	AATSA…QNKKK → EFDYGHGQYRGNNPQIQFSV SKRGGQLLWLDGMKFFRNNI NRTNLYWRCHWYYRHTKCPV LICMSKTNSNDFRQIHDHCH IRPKRKENSGTGDGPKIRTP VVSNVRSLPQSMAHMFDM in isoform D.		VSP_010285
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VKIKMEPSPTPGHSSDAAVA ALAVTYLSDEESFRKPFTLP KLLDGKFYKNIQPNQKTPGA IQATCTTCHGLISGTTKSTG NFLSHIKRRHKELLPLCQLY CQAKANGTVPAVKSSPPNPN HVLTSATPTPAMEMMTQVAQ MPPTAAYATGPTHLGMPVTV PVPVSMSLAMPISLPHVQTP QMMALMQQHQAHGAVFISKD Y in isoform E.		VSP_050699
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VVLANDEVPNPEDVLVFFTQ SLRGRPAIMANGIRFLIMSE NKKKILWRCSSMATKKLKCP ARITMLKETPPKFIINKAEH LHAELKRNKYSSSKAQTLRD PHQMATKLDCEMEGAGGVSF DLHEEELNELTHDV in isoform F.		VSP_050704
	Alternative sequence	403 – 610	208	AATSA…QNKKK → ELAVFGTGQRGRTVLLFQNE KFVKNRCSASRTYWICSKKD VTVCRARVVTAVDKNSQERI IKCTYEHDHSRKFPSNNVNL PVLIKREKALSLDAS in isoform G.		VSP_050715
	Alternative sequence	403 – 610	208	AATSA…QNKKK → DLGELNPSNLADFGNESFLP KTKGKRPQNVRCGLAPDQKC VRTLDDWDRIRYDRTRSGDV LVYDGYRYDRRANYNDIIYW GCAKKRLSCNVYMITHKNKP TYVAISGVHNHL in isoform H.		VSP_050716
	Alternative sequence	403 – 610	208	AATSA…QNKKK → VCDDLDDMKGAIKHSLLTFI RGQRGCKLLAFNGHNYVRNR RSNLKTYWICSKKGSTKCNA RVVTNVVEGVHKIVLESCHH TCLNTERKKRLSVTNVVGKA RSKSEKSVSTGFIKEEGDED LTLELRTLNLSIEDLNNLQ in isoform I.		VSP_050703
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GSVAYYSYITGFRGSRKLKI GEFSFTRNKTSGLKTYWSCA RAGVHKCKARVVTAQDHDVT IKCGQHNHPPY in isoform J.		VSP_050717
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GQFIGDIPRGQWIDKHEYFF LKNQKQGFNLVFNGYMYKKE ASFRATVNWICSDGNGKRLN ENKCSARAITKFDGGIKLGK NAHNHPPRFLGGKVPAKLMP KDAFYPQY in isoform K.		VSP_050718
	Alternative sequence	403 – 610	208	AATSA…QNKKK → DRKRYSKKFLNFDGPAEFSL AAHRRPRLIIANKHFIVHRI LGKDNLIGSWRCMYHHKGCK ARATTFMVDSEVKYRSTCSS HNHKNVRSQQQSLKMPWVFT D in isoform M.		VSP_050720
	Alternative sequence	403 – 610	208	AATSA…QNKKK → DTEISFIRSQKKNAQLVFRN YIYNKKLTQANGQTTWRCAD VLKLRCKAVVITRDGHFIDA RRQHNHESHASRIGQRQLYK VEQELEEYIEICTSNPKISQ YLGSSNIIVTAKDGKDCKLF LPAAEATEIEMQALVDAAEE ELDEEERHAEERIRDRQRVG RWRTEEAKHRSLLKSEHP in isoform N.		VSP_050700
	Alternative sequence	403 – 610	208	AATSA…QNKKK → EDELVFIESPWSTPCLVLNG YMYNCHSRKSNKQYWRCHNY SKKAHEMRCRSRCVLENGRL KSVTGGLHNHQPHTEKIDKI IQRNKMAAIGTGRKLSRTHS FTQLQLQEQKQEFIDEHQLT SDAATLQLTDQELMHASMML MHE in isoform O.		VSP_050702
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GCDGLQGSCRDRGGQKLTGA NHQMHLRA in isoform Q.		VSP_050721
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GTSHLATFSCTRKKKRKLVI DRHEFVMDRKLKSSINWRCA RYRSSNCKVRATTHVQKNGL EVYRLKYAKHSHL in isoform R.		VSP_050722
	Alternative sequence	403 – 610	208	AATSA…QNKKK → GLIFKAARHIAPIQKVRQVR DDKFLATIIKLEPAGRLNLK NPDNIIRTSSNEHNFVYVGL PRMKGKCVNCLKKNRTGLRR INTLCNTCPGSNWMCEPCFE ELHS in isoform S.		VSP_050723
	Alternative sequence	404 – 610	207	ATSAS…QNKKK → CYQLVPNRRGGKNLIFQGHM YSVERKYRNSINWVCSKNSN SVLRCPARCVTNPESGNGIK LSHRRHNHPADAFKPHKRCR KRPGDRK in isoform 53.6. Ref.5 Ref.6		VSP_010286
	Alternative sequence	404 – 610	207	ATSAS…QNKKK → FHIDFADSKKNGGKLLVING FRFFRNKKRGHLQYWKCRNY YKERCPAIAIHDESTLILRL CHQHQHTESNDIEIKPLPGS ETKLAESAEDEAQAEPEAEL DNETDPDTNHEPARVPPLIM EPPPLLEIKSKLRNQDF in isoform AC.		VSP_034706
	Alternative sequence	404 – 610	207	ATSAS…QNKKK → KDQNKGVLLKRTAQGEFLVV NGKSYKKTRAMQYRTYFHCL TRNCPTYYVLVELSRRPRLT RHHEHAQHCLQCY in isoform L.		VSP_050719
	Alternative sequence	404 – 610	207	ATSAS…QNKKK → KFDYQISVDVGEATMQLANA SSAGVVNSNSPFFIVSKYGT KQIMLKQHTFNRHICRDDVT YWRCSQFAVLRCRARLKTKL DTLTILNSEHNHEVITKARK YGSLKRQRAEAEAAARAERR QDPLETAATSAPATTT in isoform P.		VSP_050705
	Alternative sequence	459 – 610	152	GVKLI…QNKKK → DPTRPQLWSSDVPDQPQATL LTINNFVYRANLKFFGKSNN ILYWECVKTDRLSAAVALKT IGDDLYVTNGSYSAVSKCKG HLMASFHLQMCTITWATTSV LRRPRRLDADPQEVEFPHSR RQNPGFLENGHRGQPRPSAQ DVAASILPTQTFVFC in isoform mod1.8.		VSP_010289
Experimental info
	Mutagenesis	33	1	D → N in allele mod(mdg4)351; embryonic lethal; when associated with S-92.
	Mutagenesis	92	1	G → S in allele mod(mdg4)351; embryonic lethal; when associated with N-33.
	Sequence conflict	151 – 152	2	QQ → HE in AAA82988. Ref.2
	Sequence conflict	151 – 152	2	QQ → HE in AAA82989. Ref.2
	Sequence conflict	151 – 152	2	QQ → HE in AAA82990. Ref.2
	Sequence conflict	151 – 152	2	QQ → HE Ref.3
	Sequence conflict	466	1	G → V in AAL33875. Ref.9
	Sequence conflict	507	1	E → K in CAA53216. Ref.1
	Sequence conflict	507	1	E → K in CAB85487. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform mod2.2 (67.2) (E(VAR)3-93D) [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 79CC78E52D2ADAF5	FASTA	610	67,171
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQAATSASAT KIPPRKRGRP 430 440 450 460 470 480 KTKVEDQTPK PKLLEKLQAA TLNEEASEPA VYASTTKGGV KLIFNGHLFK FSFRKADYSV 490 500 510 520 530 540 FQCCYREHGE ECKVRVVCDQ KRVFPYEGEH VHFMQASDKS CLPSQFMPGE SGVISSLSPS 550 560 570 580 590 600 KELLMKNTTK LEEADDKEDE DFEEFEIQEI DEIELDEPEK TPAKEEEVDP NDFREKIKRR 610 LQKALQNKKK
	Isoform 53.1. Checksum: FDBF392D523625B0	FASTA	486	53,163
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGDATQFFF TKGQRESVKL 430 440 450 460 470 480 NYCGHSYVKF MENGRGTKWI CATRSTTKCR ARIRTTKNNY LEVLYASHNH GFPPQKKDRG RASQRM
	Isoform 53.6. Checksum: A11F19784919ECA9	FASTA	490	53,598
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQACYQLVPN RRGGKNLIFQ 430 440 450 460 470 480 GHMYSVERKY RNSINWVCSK NSNSVLRCPA RCVTNPESGN GIKLSHRRHN HPADAFKPHK 490 RCRKRPGDRK
	Isoform 54.7. Checksum: 3553CC7CF033D106	FASTA	500	54,768
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQEQEDDFKL HLPLLVTRRK 430 440 450 460 470 480 KTPGGSRKQS FDHLEVSFTR SNRGNNLLTI DGKPFTLDRR IKDVCYWECV KLRCKYIKCS 490 500 ARVVTKSNRI SALSGLHNHP
	Isoform 55.6. Checksum: 151D67B2D5AF4B09	FASTA	505	55,639
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGHLSTLRH LPVEAIFDAD 430 440 450 460 470 480 GKQMDFIPNI RVIRSQRKTI KLMFKKYAYS KTNEHDTTTY WHCRSRRNGR PACKARFSTK 490 500 KLKNGSYKVY LTQPEHNHPP KKRRL
	Isoform 59.0. Checksum: 1370A094F8362FE2	FASTA	526	57,477
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVTQHVRNC GPQMFLISRK 430 440 450 460 470 480 GGTLLTINNF VYRSNLKFFG KSNNILYWEC VQNRSVKCRS RLKTIGDDLY VTNDVHNHMG 490 500 510 520 DNKRIEAAKA AGMLIHKKLS SLTAADKIQG SWKMDTEGNP DHLPKM
	Isoform 62.3. Checksum: 3ED3199914164550	FASTA	567	62,299
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQESSVAIYS ATSRGRMQLI 430 440 450 460 470 480 YGGQPFIFEK TLKLSSGEEK RFWRCNQWWN QKCRSRVFTI NDVVCPLNRF HTHEEIVRRK 490 500 510 520 530 540 KRVRRVPPVE TIAKVVATTP RHPQHQQTTQ QQQEIQLTSD AIAGAILDDE SPATIDVSEL 550 560 GMHLKYEEIV ADVTGIVGGT RVVSRRK
	Isoform A (54.2). Checksum: AA9826AB6148038F	FASTA	485	53,387
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQEKQFEYVV SQKGHVLLLH 430 440 450 460 470 480 KKFPFIREKC INGKTYWRCT QYTTKTKCHG RLHVLNGKIV HIKTHNHSPL DQERKQYMKL QLNNV
	Isoform AA. Checksum: 4E94A618509F8E0A	FASTA	488	53,509
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVLTYDDRG KLVHEGFTFS 430 440 450 460 470 480 CYSRNPGKCL AFWRCSMYKK MHCTSALTTH IKSIKSIRGF HNHKPPERLK TFVPRVLDCP PRPHKEDY
	Isoform AC. Checksum: 639CD4CC356093A4	FASTA	540	59,341
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQAFHIDFAD SKKNGGKLLV 430 440 450 460 470 480 INGFRFFRNK KRGHLQYWKC RNYYKERCPA IAIHDESTLI LRLCHQHQHT ESNDIEIKPL 490 500 510 520 530 540 PGSETKLAES AEDEAQAEPE AELDNETDPD TNHEPARVPP LIMEPPPLLE IKSKLRNQDF
	Isoform AB. Checksum: D23436303F3941D2	FASTA	506	55,208
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGVIQSLKA LFEGKTTGAS 430 440 450 460 470 480 IQYTTTQRGR VMLVYEGYRY VVNRQSLKNV FWRCSRYVKH SCRATLVTSK VQEVTLRIAG 490 500 TPHTHAPEVS SMDLTTDLLD EFPELQ
	Isoform B (54.6). Checksum: 54808234E545F377	FASTA	498	54,592
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVTFDVLTD PIVKPDQHQL 430 440 450 460 470 480 MKRVRLSKSM EGVHYVRTPA GNVVLHCGEH RYLRNAAYKD KVYWKCSKWR KQCRSRVITH 490 ILPNGQSRYA VSGVHNHP
	Isoform C (58.0) (3). Checksum: B2111920052F391A	FASTA	534	58,074
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQDGPSKDTA IPKPAEHPRK 430 440 450 460 470 480 PVTDSVQKSP RDADAIPLFD GSRVFVSKVA LAKAYIPMPM IYTCRVMDLV IGKDKLVRIA 490 500 510 520 530 QHEETTDKDL IQDIITHVCK VFALRGNQLT PSAVQEFIDH KLSTLKLMPI KEGK
	Isoform D (57.4). Checksum: C7B5007F97844321	FASTA	520	57,399
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQEFDYGHGQ YRGNNPQIQF 430 440 450 460 470 480 SVSKRGGQLL WLDGMKFFRN NINRTNLYWR CHWYYRHTKC PVLICMSKTN SNDFRQIHDH 490 500 510 520 CHIRPKRKEN SGTGDGPKIR TPVVSNVRSL PQSMAHMFDM
	Isoform E (65.0). Checksum: A887D5F7B595684C	FASTA	603	64,967
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVKIKMEPS PTPGHSSDAA 430 440 450 460 470 480 VAALAVTYLS DEESFRKPFT LPKLLDGKFY KNIQPNQKTP GAIQATCTTC HGLISGTTKS 490 500 510 520 530 540 TGNFLSHIKR RHKELLPLCQ LYCQAKANGT VPAVKSSPPN PNHVLTSATP TPAMEMMTQV 550 560 570 580 590 600 AQMPPTAAYA TGPTHLGMPV TVPVPVSMSL AMPISLPHVQ TPQMMALMQQ HQAHGAVFIS KDY
	Isoform F (58.6). Checksum: 0CB2EA5DAA49D51F	FASTA	536	58,617
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVVLANDEV PNPEDVLVFF 430 440 450 460 470 480 TQSLRGRPAI MANGIRFLIM SENKKKILWR CSSMATKKLK CPARITMLKE TPPKFIINKA 490 500 510 520 530 EHLHAELKRN KYSSSKAQTL RDPHQMATKL DCEMEGAGGV SFDLHEEELN ELTHDV
	Isoform G (54.2). Checksum: 9FAB36A15DD9D08C	FASTA	497	54,270
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQELAVFGTG QRGRTVLLFQ 430 440 450 460 470 480 NEKFVKNRCS ASRTYWICSK KDVTVCRARV VTAVDKNSQE RIIKCTYEHD HSRKFPSNNV 490 NLPVLIKREK ALSLDAS
	Isoform H (56.3) (Doom) (MNM). Checksum: 022205D469E30597	FASTA	514	56,411
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQDLGELNPS NLADFGNESF 430 440 450 460 470 480 LPKTKGKRPQ NVRCGLAPDQ KCVRTLDDWD RIRYDRTRSG DVLVYDGYRY DRRANYNDII 490 500 510 YWGCAKKRLS CNVYMITHKN KPTYVAISGV HNHL
	Isoform I (59.1). Checksum: D7DD3B7CF114FFD2	FASTA	541	59,087
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQVCDDLDDM KGAIKHSLLT 430 440 450 460 470 480 FIRGQRGCKL LAFNGHNYVR NRRSNLKTYW ICSKKGSTKC NARVVTNVVE GVHKIVLESC 490 500 510 520 530 540 HHTCLNTERK KRLSVTNVVG KARSKSEKSV STGFIKEEGD EDLTLELRTL NLSIEDLNNL Q
	Isoform J (51.4). Checksum: 266F2F799B396F7C	FASTA	473	51,380
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGSVAYYSY ITGFRGSRKL 430 440 450 460 470 KIGEFSFTRN KTSGLKTYWS CARAGVHKCK ARVVTAQDHD VTIKCGQHNH PPY
	Isoform K (55.7). Checksum: 98A0D72C25E352D9	FASTA	510	55,771
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGQFIGDIP RGQWIDKHEY 430 440 450 460 470 480 FFLKNQKQGF NLVFNGYMYK KEASFRATVN WICSDGNGKR LNENKCSARA ITKFDGGIKL 490 500 510 GKNAHNHPPR FLGGKVPAKL MPKDAFYPQY
	Isoform L (52.2). Checksum: B185798E8C0D9179	FASTA	476	52,255
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQAKDQNKGV LLKRTAQGEF 430 440 450 460 470 LVVNGKSYKK TRAMQYRTYF HCLTRNCPTY YVLVELSRRP RLTRHHEHAQ HCLQCY
	Isoform M (55.3). Checksum: CDB2A54ABD6E6FD4	FASTA	503	55,331
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQDRKRYSKK FLNFDGPAEF 430 440 450 460 470 480 SLAAHRRPRL IIANKHFIVH RILGKDNLIG SWRCMYHHKG CKARATTFMV DSEVKYRSTC 490 500 SSHNHKNVRS QQQSLKMPWV FTD
	Isoform N (64.2). Checksum: ED213DBC04CDCE9C	FASTA	580	64,190
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQDTEISFIR SQKKNAQLVF 430 440 450 460 470 480 RNYIYNKKLT QANGQTTWRC ADVLKLRCKA VVITRDGHFI DARRQHNHES HASRIGQRQL 490 500 510 520 530 540 YKVEQELEEY IEICTSNPKI SQYLGSSNII VTAKDGKDCK LFLPAAEATE IEMQALVDAA 550 560 570 580 EEELDEEERH AEERIRDRQR VGRWRTEEAK HRSLLKSEHP
	Isoform O (60.1). Checksum: CACC30E1C0C6BF3E	FASTA	545	60,168
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQEDELVFIE SPWSTPCLVL 430 440 450 460 470 480 NGYMYNCHSR KSNKQYWRCH NYSKKAHEMR CRSRCVLENG RLKSVTGGLH NHQPHTEKID 490 500 510 520 530 540 KIIQRNKMAA IGTGRKLSRT HSFTQLQLQE QKQEFIDEHQ LTSDAATLQL TDQELMHASM MLMHE
	Isoform P (58.6). Checksum: B72215EDC9459174	FASTA	539	58,790
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQAKFDYQIS VDVGEATMQL 430 440 450 460 470 480 ANASSAGVVN SNSPFFIVSK YGTKQIMLKQ HTFNRHICRD DVTYWRCSQF AVLRCRARLK 490 500 510 520 530 TKLDTLTILN SEHNHEVITK ARKYGSLKRQ RAEAEAAARA ERRQDPLETA ATSAPATTT
	Isoform Q (46.3). Checksum: D5C44FD56D3A84BA	FASTA	430	46,366
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGCDGLQGS CRDRGGQKLT 430 GANHQMHLRA
	Isoform R (52.0). Checksum: 5F85B8A076A397A4	FASTA	475	52,074
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGTSHLATF SCTRKKKRKL 430 440 450 460 470 VIDRHEFVMD RKLKSSINWR CARYRSSNCK VRATTHVQKN GLEVYRLKYA KHSHL
	Isoform S (55.1). Checksum: 03003F412683D702	FASTA	506	55,261
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQGLIFKAAR HIAPIQKVRQ 430 440 450 460 470 480 VRDDKFLATI IKLEPAGRLN LKNPDNIIRT SSNEHNFVYV GLPRMKGKCV NCLKKNRTGL 490 500 RRINTLCNTC PGSNWMCEPC FEELHS
	Isoform mod1.8. Checksum: 85E0A9750C2A3AE2	FASTA	613	66,799
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE AQAATSASAT KIPPRKRGRP 430 440 450 460 470 480 KTKVEDQTPK PKLLEKLQAA TLNEEASEPA VYASTTKGDP TRPQLWSSDV PDQPQATLLT 490 500 510 520 530 540 INNFVYRANL KFFGKSNNIL YWECVKTDRL SAAVALKTIG DDLYVTNGSY SAVSKCKGHL 550 560 570 580 590 600 MASFHLQMCT ITWATTSVLR RPRRLDADPQ EVEFPHSRRQ NPGFLENGHR GQPRPSAQDV 610 AASILPTQTF VFC
	Isoform mod1.9. Checksum: EBC834C8A8EB3DB8	FASTA	520	57,814
	10 20 30 40 50 60 MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL SVCSPFFRKM 70 80 90 100 110 120 FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA LPAFISTAES LQIKGLTDND 130 140 150 160 170 180 PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR QQPRASARYK IETVDDGLGD EKQSTTQIVI 190 200 210 220 230 240 QTTAAPQATI VQQQQPQQAA QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV 250 260 270 280 290 300 KRSKTSTSAN VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE 310 320 330 340 350 360 AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT ENEDAGNQTA 370 380 390 400 410 420 VYASTTKGGV KLIFNGHLFK FSFRKADYSV FQCCYREHGE ECKVRVVCDQ KRVFPYEGEH 430 440 450 460 470 480 VHFMQASDKS CLPSQFMPGE SGVISSLSPS KELLMKNTTK LEEADDKEDE DFEEFEIQEI 490 500 510 520 DEIELDEPEK TPAKEEEVDP NDFREKIKRR LQKALQNKKK

References

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[1]	"The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators." Dorn R., Krauss V., Reuter G., Saumweber H. Proc. Natl. Acad. Sci. U.S.A. 90:11376-11380(1993) [PubMed: 8248257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS C AND MOD2.2), FUNCTION, SUBCELLULAR LOCATION. Strain: Oregon-R. Tissue: Embryo.
[2]	"A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation." Gerasimova T.I., Gdula D.A., Gerasimov D.V., Simonova O., Corces V.G. Cell 82:587-597(1995) [PubMed: 7664338] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MOD1.8; MOD1.9 AND MOD2.2), FUNCTION, INTERACTION WITH SU(HW).
[3]	"Doom, a product of the Drosophila mod(mdg4) gene, induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins." Harvey A.J., Bidwai A.P., Miller L.K. Mol. Cell. Biol. 17:2835-2843(1997) [PubMed: 9111355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H), FUNCTION. Strain: Canton-S.
[4]	"Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila." Buechner K., Roth P., Schotta G., Krauss V., Saumweber H., Reuter G., Dorn R. Genetics 155:141-157(2000) [PubMed: 10790390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 53.1; 53.6; 54.7; 55.6; 59.0; 62.3; B; C; D; E; F; G; H; I; J; K; M; N; O; Q; R AND S), FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[5]	"Transgene analysis proves mRNA trans-splicing at the complex mod(mdg4) locus in Drosophila." Dorn R., Reuter G., Loewendorf A. Proc. Natl. Acad. Sci. U.S.A. 98:9724-9729(2001) [PubMed: 11493677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; L; P; 53.6 AND 54.7).
[6]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[7]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[8]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kapadia B., Kronmiller B., Li P.W., Liao G. , Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 55.6; AA; E AND P). Strain: Berkeley. Tissue: Embryo.
[9]	"The gypsy insulator can act as a promoter-specific transcriptional stimulator." Wei W., Brennan M.D. Mol. Cell. Biol. 21:7714-7720(2001) [PubMed: 11604507] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 458-610 (ISOFORM MOD2.2), FUNCTION. Strain: Oregon-R.
[10]	"The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog." Georgiev P.G., Corces V.G. Proc. Natl. Acad. Sci. U.S.A. 92:5184-5188(1995) [PubMed: 7761470] [Abstract] Cited for: FUNCTION.
[11]	"Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations." Georgiev P.G., Kozycina M. Genetics 142:425-436(1996) [PubMed: 8852842] [Abstract] Cited for: FUNCTION.
[12]	"Polycomb and trithorax group proteins mediate the function of a chromatin insulator." Gerasimova T.I., Corces V.G. Cell 92:511-521(1998) [PubMed: 9491892] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[13]	"The gene mod(mdg4) affects synapse specificity and structure in Drosophila." Gorczyca M., Popova E., Jia X.-X., Budnik V. J. Neurobiol. 39:447-460(1999) [PubMed: 10363916] [Abstract] Cited for: FUNCTION.
[14]	"A chromatin insulator determines the nuclear localization of DNA." Gerasimova T.I., Byrd K., Corces V.G. Mol. Cell 6:1025-1035(2000) [PubMed: 11106742] [Abstract] Cited for: SUBCELLULAR LOCATION.
[15]	"Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins." Read D., Butte M.J., Dernburg A.F., Frasch M., Kornberg T.B. Nucleic Acids Res. 28:3864-3870(2000) [PubMed: 11024164] [Abstract] Cited for: CHARACTERIZATION OF MUTANT MOD(MDG4)351.
[16]	"Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function." Ghosh D., Gerasimova T.I., Corces V.G. EMBO J. 20:2518-2527(2001) [PubMed: 11350941] [Abstract] Cited for: SELF-ASSOCIATION, INTERACTION WITH SU(HW), SUBCELLULAR LOCATION.
[17]	"The gypsy insulator of Drosophila affects chromatin structure in a directional manner." Chen S., Corces V.G. Genetics 159:1649-1658(2001) [PubMed: 11779804] [Abstract] Cited for: FUNCTION.
[18]	"Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins." Gause M., Morcillo P., Dorsett D. Mol. Cell. Biol. 21:4807-4817(2001) [PubMed: 11416154] [Abstract] Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH CHI AND SU(HW).
[19]	"The centrosomal protein CP190 is a component of the gypsy chromatin insulator." Pai C.-Y., Lei E.P., Ghosh D., Corces V.G. Mol. Cell 16:737-748(2004) [PubMed: 15574329] [Abstract] Cited for: INTERACTION WITH CP190; SU(HW) AND TRL, SUBCELLULAR LOCATION.
[20]	"Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila." Melnikova L., Juge F., Gruzdeva N., Mazur A., Cavalli G., Georgiev P.G. Proc. Natl. Acad. Sci. U.S.A. 101:14806-14811(2004) [PubMed: 15465920] [Abstract] Cited for: INTERACTION WITH TRL.
[21]	"Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis." Thomas S.E., Soltani-Bejnood M., Roth P., Dorn R., Logsdon J.M. Jr., McKee B.D. Cell 123:555-568(2005) [PubMed: 16286005] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[22]	"The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator." Capelson M., Corces V.G. Mol. Cell 20:105-116(2005) [PubMed: 16209949] [Abstract] Cited for: INTERACTION WITH TOPORS, SUBCELLULAR LOCATION.
[23]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X75498 Genomic DNA. Translation: CAA53215.1. X75499 mRNA. Translation: CAA53216.1. U30905 mRNA. Translation: AAA82988.1. U30913 mRNA. Translation: AAA82989.1. U30914 mRNA. Translation: AAA82990.1. Sequence problems. U62802 mRNA. Translation: AAC17459.1. AJ277174 mRNA. Translation: CAB85469.1. AJ277175 mRNA. Translation: CAB85470.1. AJ277176 mRNA. Translation: CAB85471.1. AJ277177 mRNA. Translation: CAB85472.1. AJ277178 mRNA. Translation: CAB85473.1. AJ277179 mRNA. Translation: CAB85474.1. AJ277180 mRNA. Translation: CAB85475.1. AJ277181 mRNA. Translation: CAB85476.1. AJ277182 mRNA. Translation: CAB85477.1. AJ277183 mRNA. Translation: CAB85478.1. AJ277184 mRNA. Translation: CAB85479.1. AJ277185 mRNA. Translation: CAB85480.1. AJ277186 mRNA. Translation: CAB85481.1. AJ277187 mRNA. Translation: CAB85482.1. AJ277188 mRNA. Translation: CAB85483.1. AJ277189 mRNA. Translation: CAB85484.1. AJ277190 mRNA. Translation: CAB85485.1. AJ277191 mRNA. Translation: CAB85486.1. AJ277192 mRNA. Translation: CAB85487.1. AJ277193 mRNA. Translation: CAB85488.1. AJ277194 mRNA. Translation: CAB85489.1. AJ320161 mRNA. Translation: CAC51387.1. AJ320162 mRNA. Translation: CAC51487.1. AJ320163 mRNA. Translation: CAC51488.1. AJ320164 mRNA. Translation: CAC51489.1. AJ320165 mRNA. Translation: CAC51388.1. AE014297 Genomic DNA. Translation: AAF55882.2. AE014297 Genomic DNA. Translation: AAF55883.2. AE014297 Genomic DNA. Translation: AAF55884.1. AE014297 Genomic DNA. Translation: AAF55885.2. AE014297 Genomic DNA. Translation: AAF55888.1. AE014297 Genomic DNA. Translation: AAN13862.1. AE014297 Genomic DNA. Translation: AAN13863.1. AE014297 Genomic DNA. Translation: AAN13864.1. AE014297 Genomic DNA. Translation: AAN13865.1. AE014297 Genomic DNA. Translation: AAN13866.1. AE014297 Genomic DNA. Translation: AAN13867.1. AE014297 Genomic DNA. Translation: AAN13868.1. AE014297 Genomic DNA. Translation: AAN13869.1. AE014297 Genomic DNA. Translation: AAN13870.1. Different initiation. AE014297 Genomic DNA. Translation: AAN13871.1. AE014297 Genomic DNA. Translation: AAN13872.1. AE014297 Genomic DNA. Translation: AAN13873.1. AE014297 Genomic DNA. Translation: AAN13874.1. AE014297 Genomic DNA. Translation: AAN13875.1. AE014297 Genomic DNA. Translation: ABW08718.1. AE014297 Genomic DNA. Translation: ABW08719.1. AE014297 Genomic DNA. Translation: ABW08720.1. AY061580 mRNA. Translation: AAL29128.1. Sequence problems. BT003484 mRNA. Translation: AAO39487.1. BT003579 mRNA. Translation: AAO39583.1. BT029698 mRNA. Translation: ABL75755.1. AF214648 Genomic DNA. Translation: AAL33873.1. AF214649 Genomic DNA. Translation: AAL33874.1. AF214650 Genomic DNA. Translation: AAL33875.1.
RefSeq	NP_001097856.1. NP_001097857.1. NP_001097858.1. NP_524936.2. NP_732619.1. NP_732620.1. NP_732621.1. NP_732622.1. NP_732623.1. NP_732624.1. NP_732625.1. NP_732626.1. NP_732627.1. NP_732628.1. NP_732629.1. NP_732630.1. NP_732631.1. NP_732632.1. NP_732633.1. NP_732634.1. NP_732635.1. NP_732636.1.
UniGene	Dm.35861
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86B87. 40 interactions.
STRING	Q86B87.
Proteomic databases
PRIDE	Q86B87.
Genome annotation databases
Ensembl	FBtr0084060; FBpp0083459; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084061; FBpp0083460; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084062; FBpp0083461; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084063; FBpp0083462; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084064; FBpp0083463; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084065; FBpp0083464; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084066; FBpp0083465; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084067; FBpp0083466; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084068; FBpp0083467; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084069; FBpp0083468; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084070; FBpp0083469; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084071; FBpp0083470; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084072; FBpp0083471; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084073; FBpp0083472; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084074; FBpp0083473; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084075; FBpp0083474; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084076; FBpp0083475; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084077; FBpp0083476; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0084078; FBpp0083477; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0114359; FBpp0112908; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0114360; FBpp0112909; FBgn0002781; Drosophila melanogaster. [Genome view] FBtr0114361; FBpp0112910; FBgn0002781; Drosophila melanogaster. [Genome view]
GeneID	49228.
KEGG	dme:Dmel_CG32491.
Organism-specific databases
CTD	49228.
FlyBase	FBgn0002781. mod(mdg4).
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-012669-MON.
Gene expression databases
ArrayExpress	Q86B87.
GermOnline	CG32491. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007588. Znf_FLYWCH. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
Pfam	PF00651. BTB. 1 hit. PF04500. FLYWCH. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. [Graphical view]
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	839663.

Entry information

Entry name

MMD4_DROME

Accession

Primary (citable) accession number: Q86B87
Secondary accession number(s): A1A725 , A8JR64, A8JR66, P91932, Q24099, Q24100, Q24101, Q24482, Q24483, Q86B84, Q86B85, Q86B86, Q8IN28, Q8IN29, Q8IN30, Q8IN31, Q8IN32, Q8IN33, Q8IN34, Q8WTI9, Q8WTJ0, Q8WTJ1, Q95R78, Q95ZF4, Q95ZF5, Q95ZF6, Q95ZF7, Q95ZF8, Q9N6U6, Q9N6U7, Q9N6U8, Q9N6U9, Q9N6V0, Q9N6V1, Q9N6V2, Q9N6V3, Q9N6V4, Q9N6V5, Q9N6V6, Q9N6V7, Q9N6V8, Q9N6V9, Q9N6W0, Q9N6W1, Q9N6W2, Q9N6W3, Q9N6W4, Q9N6W5, Q9VDA9, Q9VDB2, Q9VDB3, Q9VDB4, Q9VDB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project