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Q86B09

- PMM2_DICDI

UniProt

Q86B09 - PMM2_DICDI

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Protein

Phosphomannomutase 2

Gene
pmmB, DDB_G0272781
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121Nucleophile By similarity
Active sitei14 – 141Proton donor/acceptor Reviewed prediction
Binding sitei21 – 211Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei141 – 1411Substrate By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei181 – 1811Substrate By similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_201995. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:pmmB
ORF Names:DDB_G0272781
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272781. pmmB.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Phosphomannomutase 2PRO_0000327517Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0231661.

Structurei

3D structure databases

ProteinModelPortaliQ86B09.
SMRiQ86B09. Positions 7-246.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.

Phylogenomic databases

eggNOGiCOG0561.
KOiK17497.
OMAiLLCKQXG.
PhylomeDBiQ86B09.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86B09-1 [UniParc]FASTAAdd to Basket

« Hide

MSQNKNTICL FDVDDTLTKP RNAITNEMKE LLASLRTKIK IGVVGGSNFN    50
KIKEQLGENF INDFDYVFAE NGLIAYKDGS LLEIQDIKKY LGEENIKKFI 100
NFVLHYVADL DIPIKRGTFV EFRNGMLNIS PIGRNCSQQE REEFEKYDLE 150
HKIRSTMVSI LKEEFKSFGL QYSIGGQISF DVFPIGWDKT YCLRHLPEDE 200
FKTLYFFGDK TFLGGNDYEI ANHPRITQSF TVKSPANTLA ILNDFFFKK 249
Length:249
Mass (Da):28,769
Last modified:April 8, 2008 - v2
Checksum:iFBF85BBCBDCC0C0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAS66964.2.
RefSeqiXP_001134630.2. XM_001134630.2.

Genome annotation databases

EnsemblProtistsiDDB0231661; DDB0231661; DDB_G0272781.
GeneIDi8618643.
KEGGiddi:DDB_G0272781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAS66964.2 .
RefSeqi XP_001134630.2. XM_001134630.2.

3D structure databases

ProteinModelPortali Q86B09.
SMRi Q86B09. Positions 7-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231661 ; DDB0231661 ; DDB_G0272781 .
GeneIDi 8618643.
KEGGi ddi:DDB_G0272781.

Organism-specific databases

dictyBasei DDB_G0272781. pmmB.

Phylogenomic databases

eggNOGi COG0561.
KOi K17497.
OMAi LLCKQXG.
PhylomeDBi Q86B09.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
Reactomei REACT_201995. Synthesis of GDP-mannose.

Miscellaneous databases

PROi Q86B09.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPMM2_DICDI
AccessioniPrimary (citable) accession number: Q86B09
Secondary accession number(s): Q1ZXM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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