Q86B06 (SDHL_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-serine dehydratase
Short name=SDH
EC=4.3.1.17

Alternative name(s):
L-serine deaminase

Gene names

Name:	sds
ORF Names:	DDB_G0272787

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from sequence or structural similarity. Source: dictyBase gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-serine ammonia-lyase activity Inferred from sequence or structural similarity. Source: dictyBase pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	L-serine dehydratase		PRO_0000327858
Regions
	Compositional bias	199 – 202	4	Poly-Gly
Amino acid modifications
	Modified residue	62	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86B06 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8BDB64D013FB6970	FASTA	350	38,457
	10 20 30 40 50 60 MGLKTTISPD SSFDKIINTK TSPPLHINSP MLESLALSKL FKEENAKVWM KVDALQPSGS 70 80 90 100 110 120 FKIRGVGLLC NQLLKEKKSK NEEAHFICSS GGNAGKSVAY AGRKLNVKTT IVLPNTIPEA 130 140 150 160 170 180 TIEKIKDEGA NVIVHGTIWD EANTFALELA EKEGCTDCYI HPFDHPLLWE GHSTMIDEIY 190 200 210 220 230 240 QDVQNGVCEK PDVILFSVGG GGMMIGILQG LDRYGWNDIP IVTVETVGSH SFWKSFQEKQ 250 260 270 280 290 300 LTKLDVSEVT SVIKTLSTRS VCSEAWEISK RFNIKPILVT DRDAVDACLK FVDDERILVE 310 320 330 340 350 PSCGATLSVL YSKKLSTLLD INSKNILTIV CGGNGTSILQ LNDLLQTLPK

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000008 Genomic DNA. Translation: EAL71031.1.
RefSeq	XP_644969.1. XM_639877.1.
3D structure databases
HSSP	HSSP built from PDB template 1PWH based on UniProtKB P09367.
ProteinModelPortal	Q86B06.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86B06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0230212; DDB0230212; DDB_G0272787.
GeneID	8618646.
GenomeReviews	Gene locus sds in contig CM000151_GR.
KEGG	ddi:DDB_G0272787.
Organism-specific databases
dictyBase	DDB_G0272787. sds.
Phylogenomic databases
eggNOG	KOG1250.
GeneTree	EPrGT00050000005199.
HOGENOM	HBG714501.
OMA	TIWDEAN.
PhylomeDB	Q86B06.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
KO	K01752.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHL_DICDI

Accession

Primary (citable) accession number: Q86B06
Secondary accession number(s): Q558U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)