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Protein

Citrate synthase

Gene

gltA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase, mitochondrial (cs), Citrate synthase (gltA), Citrate synthase, peroxisomal (cshA)
  2. Probable aconitate hydratase, mitochondrial (aco2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288PROSITE-ProRule annotation1
Active sitei327PROSITE-ProRule annotation1
Active sitei383PROSITE-ProRule annotation1

GO - Molecular functioni

  • citrate (Si)-synthase activity Source: dictyBase

GO - Biological processi

  • glyoxylate cycle Source: dictyBase

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
ORF Names:DDB_G0276965
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276965 gltA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278381 – 512Citrate synthaseAdd BLAST512

Proteomic databases

PaxDbiQ86AV6
PRIDEiQ86AV6

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0214944

Structurei

3D structure databases

ProteinModelPortaliQ86AV6
SMRiQ86AV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
InParanoidiQ86AV6
KOiK01647
OMAiDRQLYPN
PhylomeDBiQ86AV6

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
IPR010953 Citrate_synthase_typ-I
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01798 cit_synth_I, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q86AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSQEDNN KTTEKKNTLT VIDNRTGKSY EIPINHETVK SIDFRAIKEQ
60 70 80 90 100
SIDFGTMIYD PGYYNTAVCK SQITYIDGDR GILEYRGYPI EQLAEKSSFL
110 120 130 140 150
EVSYLLIYGD LPSKEQSNLW NTKIMNHTFI HENLISMMKS FRYDAHPMGM
160 170 180 190 200
LISSLSAMST FYPEANPALA GVDIYKNKQL MNKQIFRILG KLPTIAACAY
210 220 230 240 250
RHRIGRPYND PSNTLSYTEN FLYMLDRLSE SNYKPHPVLT RALDKLFIIH
260 270 280 290 300
ADHELNCSTA TMRQIASTLV DPYTACAGSA GALYGPLHGG ANEAVLRMLE
310 320 330 340 350
AIGTIENIPK FIEQVKQKKQ RLMGFGHRVY KSYDPRAKIL KTVTMEIFAL
360 370 380 390 400
LGKNPLMQIA TELERLALSD SYFIERQLYP NVDFYSGIIY KSMGFPTDMF
410 420 430 440 450
PVLFSIPRAA GWLAHWVEEL ADPELRIFRP RQIYMGRRNM NYVPMDARQV
460 470 480 490 500
QQHNSGEKLS SFSSGFDRRR DVSEELFNFE DGAIPKTATG SKSQLSASIE
510
QSFGEKISPQ SH
Length:512
Mass (Da):58,291
Last modified:June 1, 2003 - v1
Checksum:iF10C4D0F7992649D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA Translation: EAL68984.1
RefSeqiXP_642824.1, XM_637732.1

Genome annotation databases

EnsemblProtistsiEAL68984; EAL68984; DDB_G0276965
GeneIDi8620687
KEGGiddi:DDB_G0276965

Similar proteinsi

Entry informationi

Entry nameiCISYC_DICDI
AccessioniPrimary (citable) accession number: Q86AV6
Secondary accession number(s): Q550V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health