Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Citrate synthase

Gene

gltA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase, mitochondrial (cs), Citrate synthase (gltA), Citrate synthase, peroxisomal (cshA)
  2. Probable aconitate hydratase, mitochondrial (aco2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288PROSITE-ProRule annotation1
Active sitei327PROSITE-ProRule annotation1
Active sitei383PROSITE-ProRule annotation1

GO - Molecular functioni

  • citrate (Si)-synthase activity Source: dictyBase

GO - Biological processi

  • glyoxylate cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
ORF Names:DDB_G0276965
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276965. gltA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278381 – 512Citrate synthaseAdd BLAST512

Proteomic databases

PaxDbiQ86AV6.
PRIDEiQ86AV6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0214944.

Structurei

3D structure databases

ProteinModelPortaliQ86AV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiKOG2617. Eukaryota.
COG0372. LUCA.
InParanoidiQ86AV6.
KOiK01647.
OMAiFIHENLI.
PhylomeDBiQ86AV6.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSQEDNN KTTEKKNTLT VIDNRTGKSY EIPINHETVK SIDFRAIKEQ
60 70 80 90 100
SIDFGTMIYD PGYYNTAVCK SQITYIDGDR GILEYRGYPI EQLAEKSSFL
110 120 130 140 150
EVSYLLIYGD LPSKEQSNLW NTKIMNHTFI HENLISMMKS FRYDAHPMGM
160 170 180 190 200
LISSLSAMST FYPEANPALA GVDIYKNKQL MNKQIFRILG KLPTIAACAY
210 220 230 240 250
RHRIGRPYND PSNTLSYTEN FLYMLDRLSE SNYKPHPVLT RALDKLFIIH
260 270 280 290 300
ADHELNCSTA TMRQIASTLV DPYTACAGSA GALYGPLHGG ANEAVLRMLE
310 320 330 340 350
AIGTIENIPK FIEQVKQKKQ RLMGFGHRVY KSYDPRAKIL KTVTMEIFAL
360 370 380 390 400
LGKNPLMQIA TELERLALSD SYFIERQLYP NVDFYSGIIY KSMGFPTDMF
410 420 430 440 450
PVLFSIPRAA GWLAHWVEEL ADPELRIFRP RQIYMGRRNM NYVPMDARQV
460 470 480 490 500
QQHNSGEKLS SFSSGFDRRR DVSEELFNFE DGAIPKTATG SKSQLSASIE
510
QSFGEKISPQ SH
Length:512
Mass (Da):58,291
Last modified:June 1, 2003 - v1
Checksum:iF10C4D0F7992649D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68984.1.
RefSeqiXP_642824.1. XM_637732.1.

Genome annotation databases

EnsemblProtistsiEAL68984; EAL68984; DDB_G0276965.
GeneIDi8620687.
KEGGiddi:DDB_G0276965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68984.1.
RefSeqiXP_642824.1. XM_637732.1.

3D structure databases

ProteinModelPortaliQ86AV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214944.

Proteomic databases

PaxDbiQ86AV6.
PRIDEiQ86AV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68984; EAL68984; DDB_G0276965.
GeneIDi8620687.
KEGGiddi:DDB_G0276965.

Organism-specific databases

dictyBaseiDDB_G0276965. gltA.

Phylogenomic databases

eggNOGiKOG2617. Eukaryota.
COG0372. LUCA.
InParanoidiQ86AV6.
KOiK01647.
OMAiFIHENLI.
PhylomeDBiQ86AV6.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Miscellaneous databases

PROiQ86AV6.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCISYC_DICDI
AccessioniPrimary (citable) accession number: Q86AV6
Secondary accession number(s): Q550V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.