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Q86AV6 (CISYC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
ORF Names:DDB_G0276965
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subcellular location

Cytoplasm Ref.3.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from sequence or structural similarity Ref.3. Source: dictyBase

   Cellular_componentcytosol

Non-traceable author statement Ref.3. Source: dictyBase

   Molecular_functioncitrate (Si)-synthase activity

Inferred from sequence or structural similarity Ref.3. Source: dictyBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Citrate synthase
PRO_0000327838

Sites

Active site2881 By similarity
Active site3271 By similarity
Active site3831 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q86AV6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: F10C4D0F7992649D

FASTA51258,291
        10         20         30         40         50         60 
MSSNSQEDNN KTTEKKNTLT VIDNRTGKSY EIPINHETVK SIDFRAIKEQ SIDFGTMIYD 

        70         80         90        100        110        120 
PGYYNTAVCK SQITYIDGDR GILEYRGYPI EQLAEKSSFL EVSYLLIYGD LPSKEQSNLW 

       130        140        150        160        170        180 
NTKIMNHTFI HENLISMMKS FRYDAHPMGM LISSLSAMST FYPEANPALA GVDIYKNKQL 

       190        200        210        220        230        240 
MNKQIFRILG KLPTIAACAY RHRIGRPYND PSNTLSYTEN FLYMLDRLSE SNYKPHPVLT 

       250        260        270        280        290        300 
RALDKLFIIH ADHELNCSTA TMRQIASTLV DPYTACAGSA GALYGPLHGG ANEAVLRMLE 

       310        320        330        340        350        360 
AIGTIENIPK FIEQVKQKKQ RLMGFGHRVY KSYDPRAKIL KTVTMEIFAL LGKNPLMQIA 

       370        380        390        400        410        420 
TELERLALSD SYFIERQLYP NVDFYSGIIY KSMGFPTDMF PVLFSIPRAA GWLAHWVEEL 

       430        440        450        460        470        480 
ADPELRIFRP RQIYMGRRNM NYVPMDARQV QQHNSGEKLS SFSSGFDRRR DVSEELFNFE 

       490        500        510 
DGAIPKTATG SKSQLSASIE QSFGEKISPQ SH 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum."
Huang Y.-C., Chen Y.-H., Lo S.-R., Liu C.-I., Wang C.-W., Chang W.-T.
Mol. Microbiol. 53:81-91(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000019 Genomic DNA. Translation: EAL68984.1.
RefSeqXP_642824.1. XM_637732.1.

3D structure databases

ProteinModelPortalQ86AV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0214944.

Proteomic databases

PRIDEQ86AV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0214944; DDB0214944; DDB_G0276965.
GeneID8620687.
KEGGddi:DDB_G0276965.

Organism-specific databases

dictyBaseDDB_G0276965. gltA.

Phylogenomic databases

eggNOGCOG0372.
OMAFGHAVYK.
PhylomeDBQ86AV6.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISYC_DICDI
AccessionPrimary (citable) accession number: Q86AV6
Secondary accession number(s): Q550V8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase