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Protein

Citrate synthase

Gene

gltA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881PROSITE-ProRule annotation
Active sitei327 – 3271PROSITE-ProRule annotation
Active sitei383 – 3831PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: dictyBase

GO - Biological processi

  1. glyoxylate cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
ORF Names:DDB_G0276965
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276965. gltA.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Citrate synthasePRO_0000327838Add
BLAST

Proteomic databases

PRIDEiQ86AV6.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0214944.

Structurei

3D structure databases

ProteinModelPortaliQ86AV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
InParanoidiQ86AV6.
KOiK01647.
OMAiAMFTCIF.
PhylomeDBiQ86AV6.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86AV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNSQEDNN KTTEKKNTLT VIDNRTGKSY EIPINHETVK SIDFRAIKEQ
60 70 80 90 100
SIDFGTMIYD PGYYNTAVCK SQITYIDGDR GILEYRGYPI EQLAEKSSFL
110 120 130 140 150
EVSYLLIYGD LPSKEQSNLW NTKIMNHTFI HENLISMMKS FRYDAHPMGM
160 170 180 190 200
LISSLSAMST FYPEANPALA GVDIYKNKQL MNKQIFRILG KLPTIAACAY
210 220 230 240 250
RHRIGRPYND PSNTLSYTEN FLYMLDRLSE SNYKPHPVLT RALDKLFIIH
260 270 280 290 300
ADHELNCSTA TMRQIASTLV DPYTACAGSA GALYGPLHGG ANEAVLRMLE
310 320 330 340 350
AIGTIENIPK FIEQVKQKKQ RLMGFGHRVY KSYDPRAKIL KTVTMEIFAL
360 370 380 390 400
LGKNPLMQIA TELERLALSD SYFIERQLYP NVDFYSGIIY KSMGFPTDMF
410 420 430 440 450
PVLFSIPRAA GWLAHWVEEL ADPELRIFRP RQIYMGRRNM NYVPMDARQV
460 470 480 490 500
QQHNSGEKLS SFSSGFDRRR DVSEELFNFE DGAIPKTATG SKSQLSASIE
510
QSFGEKISPQ SH
Length:512
Mass (Da):58,291
Last modified:June 1, 2003 - v1
Checksum:iF10C4D0F7992649D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68984.1.
RefSeqiXP_642824.1. XM_637732.1.

Genome annotation databases

EnsemblProtistsiDDB0214944; DDB0214944; DDB_G0276965.
GeneIDi8620687.
KEGGiddi:DDB_G0276965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68984.1.
RefSeqiXP_642824.1. XM_637732.1.

3D structure databases

ProteinModelPortaliQ86AV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0214944.

Proteomic databases

PRIDEiQ86AV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0214944; DDB0214944; DDB_G0276965.
GeneIDi8620687.
KEGGiddi:DDB_G0276965.

Organism-specific databases

dictyBaseiDDB_G0276965. gltA.

Phylogenomic databases

eggNOGiCOG0372.
InParanoidiQ86AV6.
KOiK01647.
OMAiAMFTCIF.
PhylomeDBiQ86AV6.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum."
    Huang Y.-C., Chen Y.-H., Lo S.-R., Liu C.-I., Wang C.-W., Chang W.-T.
    Mol. Microbiol. 53:81-91(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: AX2.

Entry informationi

Entry nameiCISYC_DICDI
AccessioniPrimary (citable) accession number: Q86AV6
Secondary accession number(s): Q550V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.