Reviewed, UniProtKB/Swiss-Prot Q86AU1 (GSTA4_DICDI)

Names and origin

Protein names

Recommended name:
    Putative glutathione S-transferase alpha-4
    EC=2.5.1.18
Alternative name(s):
    GST class-alpha 4

Gene names

Name:	gsta4
ORF Names:	DDB_G0274263

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Sequence similarities	Belongs to the GST superfamily. Alpha family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Putative glutathione S-transferase alpha-4		PRO_0000350741
Regions
	Domain	8 – 85	78	GST N-terminal
	Domain	87 – 207	121	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q86AU1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 618933A9DF1CC27A	FASTA	225	25,955
	10 20 30 40 50 60 MMTTPTNSKP QLTSLRYRGY VQFAQVLMAF HGVDYDMCYV DKIDDQLRKE LKFDQLPLFR 70 80 90 100 110 120 ETDGFKLNQS LAITKWVGDK YDFIGKSSKE RALVVETVAC VHTDIVMPAI RSVLTGQGRD 130 140 150 160 170 180 RIINVVIPRY FGAFEKVLTE NKYLACGDSL TIADLYCYVA YDYLGHLGFA PDHLQGKFPK 190 200 210 220 IDCLKNHFES NKNVQEYLKK RPDDNEFFKN LPDWLKKDSC PTMSC

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC117070 Genomic DNA. Translation: AAO51029.1. AAFI02000012 Genomic DNA. Translation: EAL70024.1.
RefSeq	XP_644019.1.
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86AU1.
Genome annotation databases
GeneID	3395034.
GenomeReviews	Gene locus gsta4 in contig CM000151_GR.
KEGG	ddi:DDB_0231430.
Organism-specific databases
dictyBase	DDB_G0274263. gsta4.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTA4_DICDI

Accession

Primary (citable) accession number: Q86AU1
Secondary accession number(s): Q555P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	June 1, 2003
Last modified:	September 22, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)