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Protein

Vesicle-associated membrane protein 7B

Gene

vamp7B

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion (By similarity).By similarity

GO - Biological processi

  • endosome to lysosome transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • vesicle fusion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 7B
Gene namesi
Name:vamp7BImported
ORF Names:DDB_G0277173
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277173. vamp7B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189CytoplasmicSequence analysisBy similarityAdd
BLAST
Transmembranei190 – 21021Helical; Anchor for type IV membrane proteinAdd
BLAST
Topological domaini211 – 26050VesicularSequence analysisBy similarityAdd
BLAST

GO - Cellular componenti

  • contractile vacuole Source: dictyBase
  • endoplasmic reticulum membrane Source: UniProtKB
  • endosome Source: dictyBase
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • SNARE complex Source: UniProtKB
  • transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Vesicle-associated membrane protein 7BPRO_0000320002Add
BLAST

Proteomic databases

PaxDbiQ86AQ7.
PRIDEiQ86AQ7.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231542.

Structurei

3D structure databases

ProteinModelPortaliQ86AQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 110104LonginPROSITE-ProRule annotationAdd
BLAST
Domaini125 – 18662v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0859. Eukaryota.
COG5143. LUCA.
InParanoidiQ86AQ7.
KOiK08515.
OMAiRRFRNTM.
PhylomeDBiQ86AQ7.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86AQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIIYSLVAR GSSVLAEFTS TNGNFVTITR RILDLIPPND TKMSYVYEKY
60 70 80 90 100
IFHYLVSDTL TYLCMADEEF GRRIPFTFLD DVKNRFKSMY GDKGKTAIAY
110 120 130 140 150
GMNSDFSRTL ENLMDHYSNT TRVDTMSRTM AEIDEVKNIL VSDIAPQLLK
160 170 180 190 200
RGEKIEMLVE RTDTLNQQSF KFKKQSKQLK CAMWWKNVKL MLVLGAIVLI
210 220 230 240 250
IIFIIVMSYC DGFRSGSKCR SSPSSNSTPT PTPTETPTPT PTPTSTPTPS
260
QLLETLLNQF
Length:260
Mass (Da):29,561
Last modified:June 1, 2003 - v1
Checksum:iCC6EBBBCA94213DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68772.1.
RefSeqiXP_642704.1. XM_637612.1.

Genome annotation databases

EnsemblProtistsiDDB0231542; DDB0231542; DDB_G0277173.
GeneIDi8620895.
KEGGiddi:DDB_G0277173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA. Translation: EAL68772.1.
RefSeqiXP_642704.1. XM_637612.1.

3D structure databases

ProteinModelPortaliQ86AQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231542.

Proteomic databases

PaxDbiQ86AQ7.
PRIDEiQ86AQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231542; DDB0231542; DDB_G0277173.
GeneIDi8620895.
KEGGiddi:DDB_G0277173.

Organism-specific databases

dictyBaseiDDB_G0277173. vamp7B.

Phylogenomic databases

eggNOGiKOG0859. Eukaryota.
COG5143. LUCA.
InParanoidiQ86AQ7.
KOiK08515.
OMAiRRFRNTM.
PhylomeDBiQ86AQ7.

Miscellaneous databases

PROiQ86AQ7.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4Imported.

Entry informationi

Entry nameiVAM7B_DICDI
AccessioniPrimary (citable) accession number: Q86AQ7
Secondary accession number(s): Q550B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.