ID   LYST2_DICDI             Reviewed;         170 AA.
AC   Q86AA1; Q556F1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   08-NOV-2023, entry version 83.
DE   RecName: Full=Probable T4-type lysozyme 2;
DE            EC=3.2.1.17;
DE   AltName: Full=Muramidase;
GN   ORFNames=DDB_G0274291;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AX4;
RX   PubMed=15010511; DOI=10.1093/nar/gkh262;
RA   Urushihara H., Morio T., Saito T., Kohara Y., Koriki E., Ochiai H.,
RA   Maeda M., Williams J.G., Takeuchi I., Tanaka Y.;
RT   "Analyses of cDNAs from growth and slug stages of Dictyostelium
RT   discoideum.";
RL   Nucleic Acids Res. 32:1647-1653(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 24 family. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70038.1; -; Genomic_DNA.
DR   EMBL; BJ358088; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_643994.1; XM_638902.1.
DR   AlphaFoldDB; Q86AA1; -.
DR   SMR; Q86AA1; -.
DR   CAZy; GH24; Glycoside Hydrolase Family 24.
DR   PaxDb; 44689-DDB0266463; -.
DR   EnsemblProtists; EAL70038; EAL70038; DDB_G0274291.
DR   GeneID; 8619420; -.
DR   KEGG; ddi:DDB_G0274291; -.
DR   dictyBase; DDB_G0274291; lyT2-4.
DR   HOGENOM; CLU_115295_0_0_1; -.
DR   InParanoid; Q86AA1; -.
DR   PRO; PR:Q86AA1; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.530.40; -; 1.
DR   InterPro; IPR002196; Glyco_hydro_24.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR023347; Lysozyme_dom_sf.
DR   InterPro; IPR001165; T4-type_lysozyme.
DR   PANTHER; PTHR37406; T4-TYPE LYSOZYME 1-RELATED; 1.
DR   PANTHER; PTHR37406:SF1; T4-TYPE LYSOZYME 1-RELATED; 1.
DR   Pfam; PF00959; Phage_lysozyme; 1.
DR   PRINTS; PR00684; T4LYSOZYME.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
PE   2: Evidence at transcript level;
KW   Antimicrobial; Bacteriolytic enzyme; Glycosidase; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..170
FT                   /note="Probable T4-type lysozyme 2"
FT                   /id="PRO_0000328720"
FT   ACT_SITE        13
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        22
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   170 AA;  19221 MW;  376DF19EB244C558 CRC64;
     MVSSLKDMLK YDEGEKLEMY KDTEGNYTIG IGHLITKNKD KNEAIKILEG EIGHTVKLNS
     KKEPEISSSE SESLFEKDKS VAINSIENSS TLSTIYNNLD SNRKMALANM VFQMGASNVS
     KFKKSLKLIE EKKWAEAAIE LKNSTWNTQT PKRSNRVISV FETGTLKEYK
//