ID ALF_DICDI Reviewed; 357 AA. AC Q86A67; Q556D6; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 24-JAN-2024, entry version 114. DE RecName: Full=Fructose-bisphosphate aldolase; DE Short=ALDO; DE EC=4.1.2.13; GN Name=fba; ORFNames=DDB_G0274375; OS Dictyostelium discoideum (Social amoeba). OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=12097910; DOI=10.1038/nature00847; RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., RA Noegel A.A.; RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum."; RL Nature 418:79-85(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). CC -!- CATALYTIC ACTIVITY: CC Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- CC phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, CC ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 4/4. CC -!- SIMILARITY: Belongs to the class I fructose-bisphosphate aldolase CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI02000012; EAL70080.1; -; Genomic_DNA. DR RefSeq; XP_643874.1; XM_638782.1. DR AlphaFoldDB; Q86A67; -. DR SMR; Q86A67; -. DR STRING; 44689.Q86A67; -. DR PaxDb; 44689-DDB0231387; -. DR EnsemblProtists; EAL70080; EAL70080; DDB_G0274375. DR GeneID; 8619300; -. DR KEGG; ddi:DDB_G0274375; -. DR dictyBase; DDB_G0274375; fba. DR eggNOG; KOG1557; Eukaryota. DR HOGENOM; CLU_031243_0_0_1; -. DR InParanoid; Q86A67; -. DR OMA; WRAVITI; -. DR PhylomeDB; Q86A67; -. DR Reactome; R-DDI-114608; Platelet degranulation. DR Reactome; R-DDI-6798695; Neutrophil degranulation. DR Reactome; R-DDI-70171; Glycolysis. DR Reactome; R-DDI-70263; Gluconeogenesis. DR Reactome; R-DDI-70350; Fructose catabolism. DR UniPathway; UPA00109; UER00183. DR PRO; PR:Q86A67; -. DR Proteomes; UP000002195; Chromosome 2. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase. DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase. DR GO; GO:0004332; F:fructose-bisphosphate aldolase activity; ISS:dictyBase. DR GO; GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IBA:GO_Central. DR GO; GO:0006000; P:fructose metabolic process; ISS:dictyBase. DR GO; GO:0006096; P:glycolytic process; ISS:dictyBase. DR CDD; cd00948; FBP_aldolase_I_a; 1. DR Gene3D; 3.20.20.70; Aldolase class I; 1. DR InterPro; IPR029768; Aldolase_I_AS. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR000741; FBA_I. DR NCBIfam; NF033379; FrucBisAld_I; 1. DR PANTHER; PTHR11627; FRUCTOSE-BISPHOSPHATE ALDOLASE; 1. DR PANTHER; PTHR11627:SF80; FRUCTOSE-BISPHOSPHATE ALDOLASE; 1. DR Pfam; PF00274; Glycolytic; 1. DR SUPFAM; SSF51569; Aldolase; 1. DR PROSITE; PS00158; ALDOLASE_CLASS_I; 1. PE 3: Inferred from homology; KW Glycolysis; Lyase; Reference proteome; Schiff base. FT CHAIN 1..357 FT /note="Fructose-bisphosphate aldolase" FT /id="PRO_0000327835" FT ACT_SITE 183 FT /note="Proton acceptor" FT /evidence="ECO:0000250" FT ACT_SITE 225 FT /note="Schiff-base intermediate with dihydroxyacetone-P" FT /evidence="ECO:0000250" FT BINDING 49 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 140 FT /ligand="substrate" FT /evidence="ECO:0000250" SQ SEQUENCE 357 AA; 38903 MW; C6906B8DBB8CCF19 CRC64; MNSKFADELI ATAKAIVAPG KGILAADEST NTIGARFKKI NLENNEENRR AYRELLIGTG NGVNEFIGGI ILYEETLYQK MADGRLFTDV LREQKIHIGI KVDKGVVPIP GTDGETSTQG LDGLAERCKK YYEAGARFAK WRAVLKIDLA KNCPSQLSIT ENAHTLARYA AICQENGLVP IVEPEILMDG NHTVEQSAEV TEKVLAAVFK ALNDHHILLE GALLKPNMVV NGTDCPIKAT SEQIGKFTVR TLQRTVPPAL TGVVFLSGGQ TEIEATANLN AMNVLPNRPW ALSFSYGRAL QASVISTWKG ESANVEAARK VYLHRAKCNS LAQLGKYTGE ESTGSASESL YVKDYKY //