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Q86A67

- ALF_DICDI

UniProt

Q86A67 - ALF_DICDI

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Protein
Fructose-bisphosphate aldolase
Gene
fba, DDB_G0274375
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Substrate By similarity
Binding sitei140 – 1401Substrate By similarity
Active sitei183 – 1831Proton acceptor By similarity
Active sitei225 – 2251Schiff-base intermediate with dihydroxyacetone-P By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: dictyBase

GO - Biological processi

  1. fructose metabolic process Source: dictyBase
  2. glycolytic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
ALDO
Gene namesi
Name:fba
ORF Names:DDB_G0274375
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274375. fba.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: dictyBase
  2. phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Fructose-bisphosphate aldolase
PRO_0000327835Add
BLAST

Proteomic databases

PRIDEiQ86A67.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231387.

Structurei

3D structure databases

ProteinModelPortaliQ86A67.
SMRiQ86A67. Positions 6-355.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
KOiK01623.
OMAiRGQQDNA.
PhylomeDBiQ86A67.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86A67-1 [UniParc]FASTAAdd to Basket

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MNSKFADELI ATAKAIVAPG KGILAADEST NTIGARFKKI NLENNEENRR    50
AYRELLIGTG NGVNEFIGGI ILYEETLYQK MADGRLFTDV LREQKIHIGI 100
KVDKGVVPIP GTDGETSTQG LDGLAERCKK YYEAGARFAK WRAVLKIDLA 150
KNCPSQLSIT ENAHTLARYA AICQENGLVP IVEPEILMDG NHTVEQSAEV 200
TEKVLAAVFK ALNDHHILLE GALLKPNMVV NGTDCPIKAT SEQIGKFTVR 250
TLQRTVPPAL TGVVFLSGGQ TEIEATANLN AMNVLPNRPW ALSFSYGRAL 300
QASVISTWKG ESANVEAARK VYLHRAKCNS LAQLGKYTGE ESTGSASESL 350
YVKDYKY 357
Length:357
Mass (Da):38,903
Last modified:June 1, 2003 - v1
Checksum:iC6906B8DBB8CCF19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70080.1.
RefSeqiXP_643874.1. XM_638782.1.

Genome annotation databases

EnsemblProtistsiDDB0231387; DDB0231387; DDB_G0274375.
GeneIDi8619300.
KEGGiddi:DDB_G0274375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70080.1 .
RefSeqi XP_643874.1. XM_638782.1.

3D structure databases

ProteinModelPortali Q86A67.
SMRi Q86A67. Positions 6-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231387.

Proteomic databases

PRIDEi Q86A67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231387 ; DDB0231387 ; DDB_G0274375 .
GeneIDi 8619300.
KEGGi ddi:DDB_G0274375.

Organism-specific databases

dictyBasei DDB_G0274375. fba.

Phylogenomic databases

eggNOGi COG3588.
KOi K01623.
OMAi RGQQDNA.
PhylomeDBi Q86A67.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALF_DICDI
AccessioniPrimary (citable) accession number: Q86A67
Secondary accession number(s): Q556D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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