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Q86A67

- ALF_DICDI

UniProt

Q86A67 - ALF_DICDI

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491SubstrateBy similarity
    Binding sitei140 – 1401SubstrateBy similarity
    Active sitei183 – 1831Proton acceptorBy similarity
    Active sitei225 – 2251Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: dictyBase

    GO - Biological processi

    1. fructose metabolic process Source: dictyBase
    2. glycolytic process Source: dictyBase

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    ALDO
    Gene namesi
    Name:fba
    ORF Names:DDB_G0274375
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0274375. fba.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: dictyBase
    2. phagocytic vesicle Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Fructose-bisphosphate aldolasePRO_0000327835Add
    BLAST

    Proteomic databases

    PRIDEiQ86A67.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231387.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86A67.
    SMRiQ86A67. Positions 6-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    KOiK01623.
    OMAiRGQQDNA.
    PhylomeDBiQ86A67.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86A67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSKFADELI ATAKAIVAPG KGILAADEST NTIGARFKKI NLENNEENRR    50
    AYRELLIGTG NGVNEFIGGI ILYEETLYQK MADGRLFTDV LREQKIHIGI 100
    KVDKGVVPIP GTDGETSTQG LDGLAERCKK YYEAGARFAK WRAVLKIDLA 150
    KNCPSQLSIT ENAHTLARYA AICQENGLVP IVEPEILMDG NHTVEQSAEV 200
    TEKVLAAVFK ALNDHHILLE GALLKPNMVV NGTDCPIKAT SEQIGKFTVR 250
    TLQRTVPPAL TGVVFLSGGQ TEIEATANLN AMNVLPNRPW ALSFSYGRAL 300
    QASVISTWKG ESANVEAARK VYLHRAKCNS LAQLGKYTGE ESTGSASESL 350
    YVKDYKY 357
    Length:357
    Mass (Da):38,903
    Last modified:June 1, 2003 - v1
    Checksum:iC6906B8DBB8CCF19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000012 Genomic DNA. Translation: EAL70080.1.
    RefSeqiXP_643874.1. XM_638782.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231387; DDB0231387; DDB_G0274375.
    GeneIDi8619300.
    KEGGiddi:DDB_G0274375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000012 Genomic DNA. Translation: EAL70080.1 .
    RefSeqi XP_643874.1. XM_638782.1.

    3D structure databases

    ProteinModelPortali Q86A67.
    SMRi Q86A67. Positions 6-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231387.

    Proteomic databases

    PRIDEi Q86A67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231387 ; DDB0231387 ; DDB_G0274375 .
    GeneIDi 8619300.
    KEGGi ddi:DDB_G0274375.

    Organism-specific databases

    dictyBasei DDB_G0274375. fba.

    Phylogenomic databases

    eggNOGi COG3588.
    KOi K01623.
    OMAi RGQQDNA.
    PhylomeDBi Q86A67.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiALF_DICDI
    AccessioniPrimary (citable) accession number: Q86A67
    Secondary accession number(s): Q556D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3