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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49SubstrateBy similarity1
Binding sitei140SubstrateBy similarity1
Active sitei183Proton acceptorBy similarity1
Active sitei225Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-DDI-114608. Platelet degranulation.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-70171. Glycolysis.
R-DDI-70263. Gluconeogenesis.
R-DDI-70350. Fructose catabolism.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
ALDO
Gene namesi
Name:fba
ORF Names:DDB_G0274375
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274375. fba.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278351 – 357Fructose-bisphosphate aldolaseAdd BLAST357

Proteomic databases

PaxDbiQ86A67.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231387.

Structurei

3D structure databases

ProteinModelPortaliQ86A67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
InParanoidiQ86A67.
KOiK01623.
OMAiWRGQQDN.
PhylomeDBiQ86A67.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86A67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKFADELI ATAKAIVAPG KGILAADEST NTIGARFKKI NLENNEENRR
60 70 80 90 100
AYRELLIGTG NGVNEFIGGI ILYEETLYQK MADGRLFTDV LREQKIHIGI
110 120 130 140 150
KVDKGVVPIP GTDGETSTQG LDGLAERCKK YYEAGARFAK WRAVLKIDLA
160 170 180 190 200
KNCPSQLSIT ENAHTLARYA AICQENGLVP IVEPEILMDG NHTVEQSAEV
210 220 230 240 250
TEKVLAAVFK ALNDHHILLE GALLKPNMVV NGTDCPIKAT SEQIGKFTVR
260 270 280 290 300
TLQRTVPPAL TGVVFLSGGQ TEIEATANLN AMNVLPNRPW ALSFSYGRAL
310 320 330 340 350
QASVISTWKG ESANVEAARK VYLHRAKCNS LAQLGKYTGE ESTGSASESL

YVKDYKY
Length:357
Mass (Da):38,903
Last modified:June 1, 2003 - v1
Checksum:iC6906B8DBB8CCF19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70080.1.
RefSeqiXP_643874.1. XM_638782.1.

Genome annotation databases

EnsemblProtistsiEAL70080; EAL70080; DDB_G0274375.
GeneIDi8619300.
KEGGiddi:DDB_G0274375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70080.1.
RefSeqiXP_643874.1. XM_638782.1.

3D structure databases

ProteinModelPortaliQ86A67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231387.

Proteomic databases

PaxDbiQ86A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70080; EAL70080; DDB_G0274375.
GeneIDi8619300.
KEGGiddi:DDB_G0274375.

Organism-specific databases

dictyBaseiDDB_G0274375. fba.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
InParanoidiQ86A67.
KOiK01623.
OMAiWRGQQDN.
PhylomeDBiQ86A67.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
ReactomeiR-DDI-114608. Platelet degranulation.
R-DDI-6798695. Neutrophil degranulation.
R-DDI-70171. Glycolysis.
R-DDI-70263. Gluconeogenesis.
R-DDI-70350. Fructose catabolism.

Miscellaneous databases

PROiQ86A67.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF_DICDI
AccessioniPrimary (citable) accession number: Q86A67
Secondary accession number(s): Q556D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.