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Q86A21

- PSB1_DICDI

UniProt

Q86A21 - PSB1_DICDI

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Protein

Proteasome subunit beta type-1

Gene

psmB1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: dictyBase
  2. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Protein family/group databases

MEROPSiT01.986.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-1 (EC:3.4.25.1)
Gene namesi
Name:psmB1
ORF Names:DDB_G0272969
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272969. psmB1.

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. nucleus Source: dictyBase
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Proteasome subunit beta type-1PRO_0000328481Add
BLAST

Proteomic databases

PRIDEiQ86A21.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0232957.

Structurei

3D structure databases

ProteinModelPortaliQ86A21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
InParanoidiQ86A21.
KOiK02732.
OMAiGIRINII.
PhylomeDBiQ86A21.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86A21 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METLKLSALP EKDKQQPISH GRFEAYVDNG GTVLAVAGKD YCVIAGDTRM
60 70 80 90 100
SDGGYGIQTR KYTKIFQLTK KCVLATSGMQ ADTIALQKRL KSMLESFEKE
110 120 130 140 150
HGKPMSTPAI AQFLSNTLYY KRFFPYYTFN LVAGVDEQGE GWIWTYDAVG
160 170 180 190 200
SHERVKYSSQ GSGNQLVIPL LDNQVAKFNQ QIVEGNKDVS CEQVVSFVKD
210 220 230
SITSAGERDI YTGDFADIVV VDKNGVHWEK FELKLD
Length:236
Mass (Da):26,380
Last modified:June 1, 2003 - v1
Checksum:iF5BC59291CA38DE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAS66954.1.
RefSeqiXP_001134620.1. XM_001134620.1.

Genome annotation databases

EnsemblProtistsiDDB0232957; DDB0232957; DDB_G0272969.
GeneIDi8618570.
KEGGiddi:DDB_G0272969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAS66954.1 .
RefSeqi XP_001134620.1. XM_001134620.1.

3D structure databases

ProteinModelPortali Q86A21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0232957.

Protein family/group databases

MEROPSi T01.986.

Proteomic databases

PRIDEi Q86A21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0232957 ; DDB0232957 ; DDB_G0272969 .
GeneIDi 8618570.
KEGGi ddi:DDB_G0272969.

Organism-specific databases

dictyBasei DDB_G0272969. psmB1.

Phylogenomic databases

eggNOGi COG0638.
InParanoidi Q86A21.
KOi K02732.
OMAi GIRINII.
PhylomeDBi Q86A21.

Enzyme and pathway databases

Reactomei REACT_204617. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_210566. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_212010. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_214682. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217211. ER-Phagosome pathway.
REACT_217636. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_221036. Separation of Sister Chromatids.
REACT_225025. APC/C:Cdc20 mediated degradation of Securin.
REACT_226311. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_226712. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_95813. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

PROi Q86A21.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPSB1_DICDI
AccessioniPrimary (citable) accession number: Q86A21
Secondary accession number(s): Q1ZXN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3