Q86A17 (DHPR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydropteridine reductase
EC=1.5.1.34

Alternative name(s):
Quinoid dihydropteridine reductase

Gene names

Name:	qdpr
ORF Names:	DDB_G0272684

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases By similarity.
Catalytic activity	A 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H.
Subunit structure	Homodimer. Ref.3
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrobiopterin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	phagocytic vesicle Inferred from direct assay. Source: dictyBase
Molecular function	6,7-dihydropteridine reductase activity Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Ref.3 Inferred from direct assay. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Dihydropteridine reductase		PRO_0000327797
Regions
	Nucleotide binding	6 – 30	25	NADP By similarity
Sites
	Active site	138	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86A17-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0D5E03DFF4F6AA14	FASTA	231	24,651
	10 20 30 40 50 60 MSKNILVLGG SGALGAEVVK FFKSKSWNTI SIDFRENPNA DHSFTIKDSG EEEIKSVIEK 70 80 90 100 110 120 INSKSIKVDT FVCAAGGWSG GNASSDEFLK SVKGMIDMNL YSAFASAHIG AKLLNQGGLF 130 140 150 160 170 180 VLTGASAALN RTSGMIAYGA TKAATHHIIK DLASENGGLP AGSTSLGILP VTLDTPTNRK 190 200 210 220 230 YMSDANFDDW TPLSEVAEKL FEWSTNSDSR PTNGSLVKFE TKSKVTTWTN L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Crystallization and preliminary characterization of dihydropteridine reductase from Dictyostelium discoideum." Chen C., Seo K.H., Kim H.L., Zhuang N., Park Y.S., Lee K.H. Acta Crystallogr. F 64:1013-1015(2008) [PubMed: 18997329] [Abstract] Cited for: SUBUNIT, CRYSTALLIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000008 Genomic DNA. Translation: EAL70979.1.
RefSeq	XP_644903.1.
3D structure databases
HSSP	HSSP built from PDB template 1DHR based on UniProtKB P11348.
ProteinModelPortal	Q86A17.
SMR	Q86A17. Positions 2-229.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86A17.
Genome annotation databases
EnsemblProtists	DDB0237752; DDB0237752; DDB_G0272684.
GeneID	8618582.
GenomeReviews	Gene locus qdpr in contig CM000151_GR.
KEGG	ddi:DDB_G0272684.
Organism-specific databases
dictyBase	DDB_G0272684. qdpr.
Phylogenomic databases
eggNOG	KOG4022.
HOGENOM	HBG380758.
OMA	HETSRES.
PhylomeDB	Q86A17.
ProtClustDB	CLSZ2431259.
Enzyme and pathway databases
BRENDA	1.5.1.34. 424.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHPR_DICDI

Accession

Primary (citable) accession number: Q86A17
Secondary accession number(s): Q559B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	August 10, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)