Q86A17 (DHPR_DICDI)
Reviewed,
UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 52.
History...
Names and origin
| Protein names | Recommended name: Dihydropteridine reductase EC=1.5.1.34 Alternative name(s): Quinoid dihydropteridine reductase | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 231 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases By similarity. |
| Catalytic activity | A 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H. |
| Subunit structure | Homodimer. Ref.3 |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tetrahydrobiopterin biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrobiopterin biosynthetic processInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | phagocytic vesicle Inferred from direct assay. Source: dictyBase |
| Molecular function | 6,7-dihydropteridine reductase activity Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Ref.3Inferred from direct assay. Source: dictyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000008 Genomic DNA. Translation: EAL70979.1. |
| RefSeq | XP_644903.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DHR based on UniProtKB P11348. |
| ProteinModelPortal | Q86A17. |
| SMR | Q86A17. Positions 2-229. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q86A17. |
Genome annotation databases | |
| EnsemblProtists | DDB0237752; DDB0237752; DDB_G0272684. |
| GeneID | 8618582. |
| GenomeReviews | Gene locus qdpr in contig CM000151_GR. |
| KEGG | ddi:DDB_G0272684. |
Organism-specific databases | |
| dictyBase | DDB_G0272684. qdpr. |
Phylogenomic databases | |
| eggNOG | KOG4022. |
| HOGENOM | HBG380758. |
| OMA | HETSRES. |
| PhylomeDB | Q86A17. |
| ProtClustDB | CLSZ2431259. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.34. 424. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHPR_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q86A17 Secondary accession number(s): Q559B3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


