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Q869Z0

- Y5025_DICDI

UniProt

Q869Z0 - Y5025_DICDI

Protein

Putative protein disulfide-isomerase DDB_G0275025

Gene

DDB_G0275025

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: RefGenome
    3. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein disulfide-isomerase DDB_G0275025 (EC:5.3.4.1)
    Gene namesi
    ORF Names:DDB_G0275025
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0275025.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 409388Putative protein disulfide-isomerase DDB_G0275025PRO_0000388368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 60Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0167375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ869Z0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 140113ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi406 – 4094Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi246 – 25813Poly-AsnAdd
    BLAST
    Compositional biasi262 – 2676Poly-Thr

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    InParanoidiQ869Z0.
    KOiK09584.
    OMAiFEYGWIH.
    PhylomeDBiQ869Z0.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 3 hits.
    TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q869Z0-1 [UniParc]FASTAAdd to Basket

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    MKLINICIFI FAIICIESTF GFYTDNSNVI NLTKKNFQQQ VLNSQQNWMV    50
    EFYAPWCGHC KSLKPEYEKV SNNLKGLVKI GAINCDEEKE LCGQYQIQGF 100
    PTLKFFSTNP KTGKKGQPED YQGARSASEI AKFSLAKLPS NHIQKVSQDN 150
    INKFLTGTSD AKALLFTDKP KTTDLYKALS VDFFKTLTLG EARNLNKETL 200
    EKFNIDKFPT LLVFTNDDGE TFTKFDGKLT HSTIYKFLEP FSKKSNNDNN 250
    NNNNNNNNEE STKTTTTEKD PASEKFIEIK DEKSFEKSCS TGLCIVALFD 300
    QSSIDDKELN EKYLELLNTV SQNFIGRMKF VWVDVSVHDK IVPQFDLSGT 350
    PNIFVINNSK KRYTPFMGSF SDESLNSFFK SVLSGLKKAI PFTDSPKFNS 400
    QQKKQKDEL 409
    Length:409
    Mass (Da):46,536
    Last modified:June 1, 2003 - v1
    Checksum:iD631EC73ADC097D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69793.1.
    RefSeqiXP_643858.1. XM_638766.1.

    Genome annotation databases

    EnsemblProtistsiDDB0167375; DDB0167375; DDB_G0275025.
    GeneIDi8619909.
    KEGGiddi:DDB_G0275025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69793.1 .
    RefSeqi XP_643858.1. XM_638766.1.

    3D structure databases

    ProteinModelPortali Q869Z0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0167375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0167375 ; DDB0167375 ; DDB_G0275025 .
    GeneIDi 8619909.
    KEGGi ddi:DDB_G0275025.

    Organism-specific databases

    dictyBasei DDB_G0275025.

    Phylogenomic databases

    eggNOGi COG0526.
    InParanoidi Q869Z0.
    KOi K09584.
    OMAi FEYGWIH.
    PhylomeDBi Q869Z0.

    Miscellaneous databases

    PROi Q869Z0.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 3 hits.
    TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. Bienvenut W.V., Ura S., Insall R.H.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 146-171; 178-185; 237-243 AND 389-397, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: AX2.

    Entry informationi

    Entry nameiY5025_DICDI
    AccessioniPrimary (citable) accession number: Q869Z0
    Secondary accession number(s): Q553V3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3