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Q869Z0

- Y5025_DICDI

UniProt

Q869Z0 - Y5025_DICDI

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Protein

Putative protein disulfide-isomerase DDB_G0275025

Gene
DDB_G0275025
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: RefGenome
  3. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein disulfide-isomerase DDB_G0275025 (EC:5.3.4.1)
Gene namesi
ORF Names:DDB_G0275025
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275025.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 409388Putative protein disulfide-isomerase DDB_G0275025PRO_0000388368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 60Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0167375.

Structurei

3D structure databases

ProteinModelPortaliQ869Z0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 140113ThioredoxinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi406 – 4094Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 25813Poly-AsnAdd
BLAST
Compositional biasi262 – 2676Poly-Thr

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
InParanoidiQ869Z0.
KOiK09584.
OMAiFEYGWIH.
PhylomeDBiQ869Z0.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q869Z0-1 [UniParc]FASTAAdd to Basket

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MKLINICIFI FAIICIESTF GFYTDNSNVI NLTKKNFQQQ VLNSQQNWMV    50
EFYAPWCGHC KSLKPEYEKV SNNLKGLVKI GAINCDEEKE LCGQYQIQGF 100
PTLKFFSTNP KTGKKGQPED YQGARSASEI AKFSLAKLPS NHIQKVSQDN 150
INKFLTGTSD AKALLFTDKP KTTDLYKALS VDFFKTLTLG EARNLNKETL 200
EKFNIDKFPT LLVFTNDDGE TFTKFDGKLT HSTIYKFLEP FSKKSNNDNN 250
NNNNNNNNEE STKTTTTEKD PASEKFIEIK DEKSFEKSCS TGLCIVALFD 300
QSSIDDKELN EKYLELLNTV SQNFIGRMKF VWVDVSVHDK IVPQFDLSGT 350
PNIFVINNSK KRYTPFMGSF SDESLNSFFK SVLSGLKKAI PFTDSPKFNS 400
QQKKQKDEL 409
Length:409
Mass (Da):46,536
Last modified:June 1, 2003 - v1
Checksum:iD631EC73ADC097D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69793.1.
RefSeqiXP_643858.1. XM_638766.1.

Genome annotation databases

EnsemblProtistsiDDB0167375; DDB0167375; DDB_G0275025.
GeneIDi8619909.
KEGGiddi:DDB_G0275025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69793.1 .
RefSeqi XP_643858.1. XM_638766.1.

3D structure databases

ProteinModelPortali Q869Z0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0167375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0167375 ; DDB0167375 ; DDB_G0275025 .
GeneIDi 8619909.
KEGGi ddi:DDB_G0275025.

Organism-specific databases

dictyBasei DDB_G0275025.

Phylogenomic databases

eggNOGi COG0526.
InParanoidi Q869Z0.
KOi K09584.
OMAi FEYGWIH.
PhylomeDBi Q869Z0.

Miscellaneous databases

PROi Q869Z0.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 3 hits.
TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. Bienvenut W.V., Ura S., Insall R.H.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 146-171; 178-185; 237-243 AND 389-397, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: AX2.

Entry informationi

Entry nameiY5025_DICDI
AccessioniPrimary (citable) accession number: Q869Z0
Secondary accession number(s): Q553V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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