Q869X7 (HAT12_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B catalytic subunit DDB_G0275159
EC=2.3.1.48

Gene names

ORF Names:

DDB_G0275159

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Sequence similarities	Belongs to the HAT1 family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Domain	Coiled coil
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro
Cellular component	histone acetyltransferase complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Histone acetyltransferase type B catalytic subunit DDB_G0275159		PRO_0000367832
Regions
	Domain	169 – 366	198	N-acetyltransferase
	Coiled coil	372 – 459	88	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q869X7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 16FDB57EB0E4565B	FASTA	466	55,013
	10 20 30 40 50 60 MTSKIKSSNT LLTFDANEVT NIKLVWDIEE LKNKDKEDKA HIKDEEEDED GPVSFHPSFS 70 80 90 100 110 120 HQIFNDEQVQ GYEACKIDIY MGAGSLTSYI DTNYTLQSKN LTNVEGELLK VFSKQDPPIS 130 140 150 160 170 180 KQSFYKFIEE KEKSFKPIGK KIHEYTITDK ESGEETEYEV YFGRITDQAV FRYHEKLQIF 190 200 210 220 230 240 VLWYIDGSSY IWTDDPNWDI FFIFEKRIID GEKRYGITGY STIYNFYHHP EQTRARISQY 250 260 270 280 290 300 LILPPYQRMG HGKYLFNSIH QYYKTNDGFY GPVYDVTIED PADDFNLLRN YVDLKNIIDE 310 320 330 340 350 360 KLFDNVILDL NANNKSVFEE IRKKLLVPHK QSKVCLEIYL FSKFLATPNS NPKYKEFRIA 370 380 390 400 410 420 IKKRLYKQNI GDSEQIEKMK QQVAQENEDN LRLEQEELQE LQDIENKKNG TNIKVAINTK 430 440 450 460 ELTTPSEPEK SKEEIEKDRL EEIIQLYKDL EENYHKTLSS LNLITK

References

[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000013 Genomic DNA. Translation: EAL69860.1.
RefSeq	XP_643818.1. XM_638726.1.
3D structure databases
HSSP	HSSP built from PDB template 1BOB based on UniProtKB Q12341.
ProteinModelPortal	Q869X7.
ModBase	Search...
Proteomic databases
PRIDE	Q869X7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237833; DDB0237833; DDB_G0275159.
GeneID	8619865.
KEGG	ddi:DDB_G0275159.
Organism-specific databases
dictyBase	DDB_G0275159.
Phylogenomic databases
eggNOG	KOG2696.
GeneTree	EPrGT00050000005100.
HOGENOM	HBG076700.
OMA	WINSKIA.
PhylomeDB	Q869X7.
ProtClustDB	CLSZ2430988.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:3.90.360.10. G3DSA:3.90.360.10. 2 hits.
KO	K11303.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT12_DICDI

Accession

Primary (citable) accession number: Q869X7
Secondary accession number(s): Q553Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)