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Q869X7

- HAT12_DICDI

UniProt

Q869X7 - HAT12_DICDI

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Protein

Histone acetyltransferase type B catalytic subunit DDB_G0275159

Gene

DDB_G0275159

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei198 – 1981Interaction with histone H4 N-terminusBy similarity
Active sitei279 – 2791Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. histone acetylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit DDB_G0275159 (EC:2.3.1.48By similarity)
Gene namesi
ORF Names:DDB_G0275159
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275159.

Subcellular locationi

GO - Cellular componenti

  1. histone acetyltransferase complex Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Histone acetyltransferase type B catalytic subunit DDB_G0275159PRO_0000367832Add
BLAST

Proteomic databases

PRIDEiQ869X7.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0167416.

Structurei

3D structure databases

ProteinModelPortaliQ869X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 366198N-acetyltransferaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 2423Acetyl-CoA bindingBy similarity
Regioni247 – 2537Acetyl-CoA bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili372 – 45988Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAT1 family.Curated
Contains 1 N-acetyltransferase domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG326277.
InParanoidiQ869X7.
KOiK11303.
OMAiGPVYDVT.
PhylomeDBiQ869X7.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q869X7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSKIKSSNT LLTFDANEVT NIKLVWDIEE LKNKDKEDKA HIKDEEEDED
60 70 80 90 100
GPVSFHPSFS HQIFNDEQVQ GYEACKIDIY MGAGSLTSYI DTNYTLQSKN
110 120 130 140 150
LTNVEGELLK VFSKQDPPIS KQSFYKFIEE KEKSFKPIGK KIHEYTITDK
160 170 180 190 200
ESGEETEYEV YFGRITDQAV FRYHEKLQIF VLWYIDGSSY IWTDDPNWDI
210 220 230 240 250
FFIFEKRIID GEKRYGITGY STIYNFYHHP EQTRARISQY LILPPYQRMG
260 270 280 290 300
HGKYLFNSIH QYYKTNDGFY GPVYDVTIED PADDFNLLRN YVDLKNIIDE
310 320 330 340 350
KLFDNVILDL NANNKSVFEE IRKKLLVPHK QSKVCLEIYL FSKFLATPNS
360 370 380 390 400
NPKYKEFRIA IKKRLYKQNI GDSEQIEKMK QQVAQENEDN LRLEQEELQE
410 420 430 440 450
LQDIENKKNG TNIKVAINTK ELTTPSEPEK SKEEIEKDRL EEIIQLYKDL
460
EENYHKTLSS LNLITK
Length:466
Mass (Da):55,013
Last modified:June 1, 2003 - v1
Checksum:i16FDB57EB0E4565B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69860.1.
RefSeqiXP_643818.1. XM_638726.1.

Genome annotation databases

EnsemblProtistsiDDB0237833; DDB0237833; DDB_G0275159.
GeneIDi8619865.
KEGGiddi:DDB_G0275159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69860.1 .
RefSeqi XP_643818.1. XM_638726.1.

3D structure databases

ProteinModelPortali Q869X7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0167416.

Proteomic databases

PRIDEi Q869X7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0237833 ; DDB0237833 ; DDB_G0275159 .
GeneIDi 8619865.
KEGGi ddi:DDB_G0275159.

Organism-specific databases

dictyBasei DDB_G0275159.

Phylogenomic databases

eggNOGi NOG326277.
InParanoidi Q869X7.
KOi K11303.
OMAi GPVYDVT.
PhylomeDBi Q869X7.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiHAT12_DICDI
AccessioniPrimary (citable) accession number: Q869X7
Secondary accession number(s): Q553Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3