Q869K3 (BPNT1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3'(2'),5'-bisphosphate nucleotidase 1
EC=3.1.3.7

Alternative name(s):
Bisphosphate 3'-nucleotidase 1

Gene names

Name:	bpnt1
ORF Names:	DDB_G0275663

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP By similarity.
Catalytic activity	Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	3'(2'),5'-bisphosphate nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 311	310	3'(2'),5'-bisphosphate nucleotidase 1		PRO_0000328596
Regions
	Region	118 – 121	4	Substrate binding By similarity
	Region	202 – 205	4	Substrate binding By similarity
Sites
	Metal binding	72	1	Magnesium 1 By similarity
	Metal binding	116	1	Magnesium 1 By similarity
	Metal binding	116	1	Magnesium 2 By similarity
	Metal binding	119	1	Magnesium 2 By similarity
	Metal binding	254	1	Magnesium 2 By similarity
	Binding site	72	1	Substrate By similarity
	Binding site	254	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q869K3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 132687DC4EA7F31F	FASTA	311	34,057
	10 20 30 40 50 60 MSKTLNILEL TSACIKLAQE SGDIIRDVFK SGSLGIEMKS VDDPMTKADL LSQQHIIGSL 70 80 90 100 110 120 RTIWSDIKIV GEEQCEIPTI DKKPPIDLLA NDKDCIEKCP EEFKQLPIDD LIIFIDPLDA 130 140 150 160 170 180 TREFTLGRVG CVMTLIGISF KGKPIAGIIY QPFVDCNGDG TTDQSKWVGR TIWAIVGGGI 190 200 210 220 230 240 PVKGIKDRRA PEDVGKVILT TTASHFNDKV QQAVDAIKPD KLLRAGGAGY KSLLVIENQA 250 260 270 280 290 300 DVYVFPTVGS KLWDICGPHA ILLAVGGKLT DPQGNDIIYS TDPEKIENKN GIIITISNHQ 310 KYIDLLKNFK N

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000013 Genomic DNA. Translation: EAL69582.1.
RefSeq	XP_643514.1. XM_638422.1.
3D structure databases
HSSP	HSSP built from PDB template 1JP4 based on UniProtKB Q9Z1N4.
ProteinModelPortal	Q869K3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q869K3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266708; DDB0266708; DDB_G0275663.
GeneID	8620095.
GenomeReviews	Gene locus bpnt1 in contig CM000151_GR.
KEGG	ddi:DDB_G0275663.
Organism-specific databases
dictyBase	DDB_G0275663. ippA.
Phylogenomic databases
eggNOG	KOG3099.
GeneTree	EPrGT00050000006010.
HOGENOM	HBG380847.
OMA	AHAYVFA.
PhylomeDB	Q869K3.
ProtClustDB	CLSZ2430950.
Family and domain databases
InterPro	IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
KO	K01082.
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PROSITE	PS00629. IMP_1. False negative. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BPNT1_DICDI

Accession

Primary (citable) accession number: Q869K3
Secondary accession number(s): Q553A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)