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Protein

Acetylcholinesterase

Gene

Ace

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rapidly hydrolyzes choline released into the synapse.Curated

Catalytic activityi

Acetylcholine + H2O = choline + acetate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei486Charge relay systemBy similarity1
Active sitei600Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processNeurotransmitter degradation

Protein family/group databases

ESTHERianoga-ACHE1 AChE

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:Ace
Synonyms:ACE1, ACHE1
ORF Names:AGAP001356
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2R, Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2046266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000000859939 – 737AcetylcholinesteraseAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi228 ↔ 255By similarity
Disulfide bondi414 ↔ 427By similarity
Disulfide bondi562 ↔ 683By similarity
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ869C3
PRIDEiQ869C3

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP001356-PA

Chemistry databases

BindingDBiQ869C3

Structurei

Secondary structure

1737
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi167 – 170Combined sources4
Beta strandi173 – 176Combined sources4
Beta strandi178 – 181Combined sources4
Beta strandi187 – 195Combined sources9
Helixi202 – 204Combined sources3
Beta strandi217 – 220Combined sources4
Beta strandi227 – 229Combined sources3
Turni235 – 238Combined sources4
Helixi240 – 243Combined sources4
Beta strandi251 – 253Combined sources3
Beta strandi257 – 265Combined sources9
Beta strandi268 – 276Combined sources9
Turni280 – 282Combined sources3
Helixi289 – 291Combined sources3
Helixi294 – 300Combined sources7
Beta strandi303 – 307Combined sources5
Helixi312 – 316Combined sources5
Beta strandi318 – 321Combined sources4
Beta strandi324 – 326Combined sources3
Helixi328 – 343Combined sources16
Helixi344 – 347Combined sources4
Beta strandi349 – 359Combined sources11
Helixi361 – 371Combined sources11
Turni373 – 377Combined sources5
Beta strandi380 – 386Combined sources7
Turni392 – 394Combined sources3
Helixi398 – 411Combined sources14
Helixi421 – 428Combined sources8
Helixi433 – 438Combined sources6
Beta strandi457 – 459Combined sources3
Helixi464 – 470Combined sources7
Beta strandi478 – 483Combined sources6
Beta strandi485 – 487Combined sources3
Helixi488 – 494Combined sources7
Turni496 – 498Combined sources3
Helixi509 – 519Combined sources11
Helixi525 – 534Combined sources10
Helixi544 – 559Combined sources16
Helixi561 – 573Combined sources13
Beta strandi578 – 583Combined sources6
Helixi594 – 596Combined sources3
Turni600 – 603Combined sources4
Helixi604 – 607Combined sources4
Helixi610 – 612Combined sources3
Helixi614 – 616Combined sources3
Helixi620 – 639Combined sources20
Beta strandi649 – 651Combined sources3
Turni659 – 661Combined sources3
Beta strandi663 – 668Combined sources6
Beta strandi674 – 679Combined sources6
Helixi680 – 687Combined sources8
Helixi689 – 696Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AZGmodel-A115-737[»]
5X61X-ray3.40A/B162-714[»]
5YDHX-ray3.21A/B162-737[»]
5YDIX-ray3.45A/B/C162-714[»]
5YDJX-ray3.04A/B1-737[»]
6ARXX-ray2.30A/B162-702[»]
6ARYX-ray2.26A/B162-702[»]
ProteinModelPortaliQ869C3
SMRiQ869C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
HOGENOMiHOG000091866
InParanoidiQ869C3
KOiK01049
OMAiFDHYSKQ
OrthoDBiEOG091G05SE
PhylomeDBiQ869C3

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q869C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIRGLLMGR LRLGRRMVPL GLLGVTALLL ILPPFALVQG RHHELNNGAA
60 70 80 90 100
IGSHQLSAAA GVGLASQSAQ SGSLASGVMS SVPAAGASSS SSSSLLSSSA
110 120 130 140 150
EDDVARITLS KDADAFFTPY IGHGESVRII DAELGTLEHV HSGATPRRRG
160 170 180 190 200
LTRRESNSDA NDNDPLVVNT DKGRIRGITV DAPSGKKVDV WLGIPYAQPP
210 220 230 240 250
VGPLRFRHPR PAEKWTGVLN TTTPPNSCVQ IVDTVFGDFP GATMWNPNTP
260 270 280 290 300
LSEDCLYINV VAPRPRPKNA AVMLWIFGGG FYSGTATLDV YDHRALASEE
310 320 330 340 350
NVIVVSLQYR VASLGFLFLG TPEAPGNAGL FDQNLALRWV RDNIHRFGGD
360 370 380 390 400
PSRVTLFGES AGAVSVSLHL LSALSRDLFQ RAILQSGSPT APWALVSREE
410 420 430 440 450
ATLRALRLAE AVGCPHEPSK LSDAVECLRG KDPHVLVNNE WGTLGICEFP
460 470 480 490 500
FVPVVDGAFL DETPQRSLAS GRFKKTEILT GSNTEEGYYF IIYYLTELLR
510 520 530 540 550
KEEGVTVTRE EFLQAVRELN PYVNGAARQA IVFEYTDWTE PDNPNSNRDA
560 570 580 590 600
LDKMVGDYHF TCNVNEFAQR YAEEGNNVYM YLYTHRSKGN PWPRWTGVMH
610 620 630 640 650
GDEINYVFGE PLNPTLGYTE DEKDFSRKIM RYWSNFAKTG NPNPNTASSE
660 670 680 690 700
FPEWPKHTAH GRHYLELGLN TSFVGRGPRL RQCAFWKKYL PQLVAATSNL
710 720 730
PGPAPPSEPC ESSAFFYRPD LIVLLVSLLT ATVRFIQ
Length:737
Mass (Da):80,902
Last modified:April 4, 2006 - v3
Checksum:iFDE9CCAE34DF2421
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35F → S in CAD56157 (PubMed:12736674).Curated1
Sequence conflicti65A → S in CAD56157 (PubMed:12736674).Curated1

Polymorphismi

Strains Kisumu and Kisumu2 are susceptible to insecticides while strain YAO is resistant. Insensitivity to insecticides results from a loss of sensitivity of acetylcholinesterase to organophosphates and carbamates and is due to a variant at position 280.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti127V → A in strain: Kisumu2 and YAO. 1
Natural varianti280G → S in strain: YAO; confers resistance to insecticides. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ488492 Genomic DNA Translation: CAD32684.2
AJ515149, AJ515148 Genomic DNA Translation: CAD56156.1
AJ515150, AJ488492 Genomic DNA Translation: CAD56157.2
AAAB01008987 Genomic DNA Translation: EAA01151.3
BN000066 Genomic DNA Translation: CAD29865.2
RefSeqiXP_321792.2, XM_321792.4

Genome annotation databases

EnsemblMetazoaiAGAP001356-RA; AGAP001356-PA; AGAP001356
GeneIDi1281827
KEGGiaga:AgaP_AGAP001356
VectorBaseiAGAP001356-RA; AGAP001356-PA; AGAP001356

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiACES_ANOGA
AccessioniPrimary (citable) accession number: Q869C3
Secondary accession number(s): Q7PUR2
, Q7RTM0, Q86GC7, Q8ISM4, Q8ISM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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