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Protein

Vitellogenin

Gene

Vg

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (By similarity). Involved in the differentiation of honeybee larvae into queens.By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin
Gene namesi
Name:Vg
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10030. Api m 12.
10031. Api m 12.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 17701754VitellogeninPRO_5000070065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 222PROSITE-ProRule annotation
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1067 – 10671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ868N5.
PRIDEiQ868N5.

Expressioni

Tissue specificityi

Accumulates in the hemolymph. Represents up to 70% of the queen's hemolymph proteins. During the first week of the worker adult life, when it becomes a nurse bee and performs brood-rearing tasks, the vitellogenin titer increases and may account for up to 40% of the total hemolymph proteins.1 Publication

Developmental stagei

In queens, first expressed in mid-late pupal stage and a high production is maintained throughout adult life. In workers, observed in late pupal stage and expressed at low levels in adults. Levels can increase in some young workers if an egg-laying queen is missing to the colony. Also detected in drones, but in freshly molted adults and not in pupae.1 Publication

Inductioni

By MRJP1 during the differentiation of honeybee larvae into queens.1 Publication

Structurei

Secondary structure

1
1770
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi364 – 3663Combined sources
Beta strandi368 – 3714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LICNMR-A358-392[»]
ProteinModelPortaliQ868N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 809788VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini1442 – 1670229VWFDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi349 – 38133Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR4. Eukaryota.
ENOG4110M1Q. LUCA.
InParanoidiQ868N5.
PhylomeDBiQ868N5.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q868N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLTLLLF AGTVAADFQH NWQVGNEYTY LVRSRTLTSL GDLSDVHTGI
60 70 80 90 100
LIKALLTVQA KDSNVLAAKV WNGQYARVQQ SMPDGWETEI SDQMLELRDL
110 120 130 140 150
PISGKPFQIR MKHGLIRDLI VDRDVPTWEV NILKSIVGQL QVDTQGENAV
160 170 180 190 200
KVNSVQVPTD DEPYASFKAM EDSVGGKCEV LYDIAPLSDF VIHRSPELVP
210 220 230 240 250
MPTLKGDGRH MEVIKIKNFD NCDQRINYHF GMTDNSRLEP GTNKNGKFFS
260 270 280 290 300
RSSTSRIVIS ESLKHFTIQS SVTTSKMMVS PRLYDRQNGL VLSRMNLTLA
310 320 330 340 350
KMEKTSKPLP MVDNPESTGN LVYIYNNPFS DVEERRVSKT AMNSNQIVSD
360 370 380 390 400
NSLSSSEEKL KQDILNLRTD ISSSSSSISS SEENDFWQPK PTLEDAPQNS
410 420 430 440 450
LLPNFVGYKG KHIGKSGKVD VINAAKELIF QIANELEDAS NIPVHATLEK
460 470 480 490 500
FMILCNLMRT MNRKQISELE SNMQISPNEL KPNDKSQVIK QNTWTVFRDA
510 520 530 540 550
ITQTGTGPAF LTIKEWIERG TTKSMEAANI MSKLPKTVRT PTDSYIRSFF
560 570 580 590 600
ELLQNPKVSN EQFLNTAATL SFCEMIHNAQ VNKRSIHNNY PVHTFGRLTS
610 620 630 640 650
KHDNSLYDEY IPFLERELRK AHQEKDSPRI QTYIMALGMI GEPKILSVFE
660 670 680 690 700
PYLEGKQQMT VFQRTLMVGS LGKLTETNPK LARSVLYKIY LNTMESHEVR
710 720 730 740 750
CTAVFLLMKT NPPLSMLQRM AEFTKLDTNR QVNSAVKSTI QSLMKLKSPE
760 770 780 790 800
WKDLAKKARS VNHLLTHHEY DYELSRGYID EKILENQNII THMILNYVGS
810 820 830 840 850
EDSVIPRILY LTWYSSNGDI KVPSTKVLAM ISSVKSFMEL SLRSVKDRET
860 870 880 890 900
IISAAEKIAE ELKIVPEELV PLEGNLMINN KYALKFFPFD KHILDKLPTL
910 920 930 940 950
ISNYIEAVKE GKFMNVNMLD TYESVHSFPT ETGLPFVYTF NVIKLTKTSG
960 970 980 990 1000
TVQAQINPDF AFIVNSNLRL TFSKNVQGRV GFVTPFEHRH FISGIDSNLH
1010 1020 1030 1040 1050
VYAPLKISLD VNTPKGNMQW KIWPMKGEEK SRLFHYSVVP FVSNHDILNL
1060 1070 1080 1090 1100
RPLSMEKGTR PMIPDDNTSL ALPKNEGPFR LNVETAKTNE EMWELIDTEK
1110 1120 1130 1140 1150
LTDRLPYPWT MDNERYVKVD MYMNLEGEQK DPVIFSTSFD SKVMTRPDTD
1160 1170 1180 1190 1200
SENWTPKMMA VEPTDKQANS KTRRQEMMRE AGRGIESAKS YVVDVRVHVP
1210 1220 1230 1240 1250
GESESETVLT LAWSESNVES KGRLLGFWRV EMPRSNADYE VCIGSQIMVS
1260 1270 1280 1290 1300
PETLLSYDEK MDQKPKMDFN VDIRYGKNCG KGERIDMNGK LRQSPRLKEL
1310 1320 1330 1340 1350
VGATSIIKDC VEDMKRGNKI LRTCQKAVVL SMLLDEVDIS MEVPSDALIA
1360 1370 1380 1390 1400
LYSQGLFSLS EIDNLDVSLD VSNPKNAGKK KIDVRAKLNE YLDKADVIVN
1410 1420 1430 1440 1450
TPIMDAHFKD VKLSDFGFST EDILDTADED LLINNVFYED ETSCMLDKTR
1460 1470 1480 1490 1500
AQTFDGKDYP LRLGPCWHAV MTTYPRINPD NHNEKLHIPK DKSVSVLSRE
1510 1520 1530 1540 1550
NEAGQKEVKV LLGSDKIKFV PGTTSQPEVF VNGEKIVVSR NKAYQKVEEN
1560 1570 1580 1590 1600
EIIFEIYKMG DRFIGLTSDK FDVSLALDGE RVMLKASEDY RYSVRGLCGN
1610 1620 1630 1640 1650
FDHDSTNDFV GPKNCLFRKP EHFVASYALI SNQCEGDSLN VAKSLQDHDC
1660 1670 1680 1690 1700
IRQERTQQRN VISDSESGRL DTEMSTWGYH HNVNKHCTIH RTQVKETDDK
1710 1720 1730 1740 1750
ICFTMRPVVS CASGCTAVET KSKPYKFHCM EKNEAAMKLK KRIEKGANPD
1760 1770
LSQKPVSTTE ELTVPFVCKA
Length:1,770
Mass (Da):201,048
Last modified:June 1, 2003 - v1
Checksum:iFF42F06CC053ABBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ517411 mRNA. Translation: CAD56944.1.
RefSeqiNP_001011578.1. NM_001011578.1.
UniGeneiAme.206.

Genome annotation databases

GeneIDi406088.
KEGGiame:406088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ517411 mRNA. Translation: CAD56944.1.
RefSeqiNP_001011578.1. NM_001011578.1.
UniGeneiAme.206.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LICNMR-A358-392[»]
ProteinModelPortaliQ868N5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei10030. Api m 12.
10031. Api m 12.0101.

Proteomic databases

PaxDbiQ868N5.
PRIDEiQ868N5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406088.
KEGGiame:406088.

Organism-specific databases

CTDi36421.

Phylogenomic databases

eggNOGiENOG410IKR4. Eukaryota.
ENOG4110M1Q. LUCA.
InParanoidiQ868N5.
PhylomeDBiQ868N5.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The vitellogenin of the honey bee, Apis mellifera: structural analysis of the cDNA and expression studies."
    Piulachs M.D., Guidugli K.R., Barchuk A.R., Cruz J., Simoes Z.L.P., Belles X.
    Insect Biochem. Mol. Biol. 33:459-465(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Fat body.
  2. "Royalactin induces queen differentiation in honeybees."
    Kamakura M.
    Nature 473:478-483(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY MRJP1.

Entry informationi

Entry nameiVIT_APIME
AccessioniPrimary (citable) accession number: Q868N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.