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Q868M7

- Q868M7_CUCEC

UniProt

Q868M7 - Q868M7_CUCEC

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Protein
Submitted name:

Hemolytic lectin CEL-III

Gene

cel3

Organism
Cucumaria echinata (Sea cucumber)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

CalciumImported, LectinImported, MagnesiumImported, Metal-bindingImported

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Hemolytic lectin CEL-IIIImported
Gene namesi
Name:cel3Imported
OrganismiCucumaria echinata (Sea cucumber)Imported
Taxonomic identifieri40245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaDendrochirotaceaDendrochirotidaCucumariidaeCucumaria

PTM / Processingi

Keywords - PTMi

Pyrrolidone carboxylic acidImported

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VCLX-ray1.70A/B11-442[»]
2Z48X-ray1.70A/B11-442[»]
2Z49X-ray1.95A/B12-442[»]
3W9TX-ray2.90A/B/C/D/E/F/G12-442[»]
ProteinModelPortaliQ868M7.
SMRiQ868M7. Positions 12-442.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ868M7.

Family & Domainsi

Family and domain databases

Gene3Di3.30.1750.10. 1 hit.
InterProiIPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
[Graphical view]
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q868M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLVPCGFA QVLCTNPLDI GELRNYKSKQ CVDIVGNQGS GNIATHDCDG
60 70 80 90 100
LSDQQIIMCG DGTIRNEARN YCFTPDGSGN ANVMSSPCTL YPEIPSSQRW
110 120 130 140 150
RLGRKKAFTD NGGIEQVATE IINLASGKCL DVEGSDGTGD IGVYDCQNLD
160 170 180 190 200
DQYFYIRSRG PELFYGRLRN EKSDLCLDVE GSEGKGNVLM YSCEDNLDQW
210 220 230 240 250
FRYYENGEIV NAKQGMCLDV EGSDGSGNVG IYRCDDLRDQ MWSRPNAYCN
260 270 280 290 300
GDYCSFLNKE SNKCLDVSGD QGTGDVGTWQ CDGLPDQRFK WVFDDWEVPT
310 320 330 340 350
ATWNMVGCDQ NGKVSQQISN TISFSSTVTA GVAVEVSSTI EKGVIFAKAS
360 370 380 390 400
VSVKVTASLS KAWTNSQSGT TAITYTCDNY DSDEEFTRGC MWQLAIETTE
410 420 430 440
VKSGDLLVWN PQIIKCTRSN TAPGCAPFTK CANEDCTFCT DI
Length:442
Mass (Da):48,456
Last modified:June 1, 2003 - v1
Checksum:i3E47C608446D40EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109017 mRNA. Translation: BAC75827.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109017 mRNA. Translation: BAC75827.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VCL X-ray 1.70 A/B 11-442 [» ]
2Z48 X-ray 1.70 A/B 11-442 [» ]
2Z49 X-ray 1.95 A/B 12-442 [» ]
3W9T X-ray 2.90 A/B/C/D/E/F/G 12-442 [» ]
ProteinModelPortali Q868M7.
SMRi Q868M7. Positions 12-442.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
TCDBi 1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q868M7.

Family and domain databases

Gene3Di 3.30.1750.10. 1 hit.
InterProi IPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00652. Ricin_B_lectin. 2 hits.
[Graphical view ]
SMARTi SM00458. RICIN. 2 hits.
[Graphical view ]
SUPFAMi SSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEi PS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of hemolytic lectin CEL-III from marine invertebrate Cucumaria echinata and its cDNA: structural similarity to the B-chain from plant lectin, ricin."
    Nakano M., Tabata S., Sugihara K., Kouzuma Y., Kimura M., Yamasaki N.
    Biochim. Biophys. Acta 1435:167-176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Kouzuma Y.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Crystal structure of the hemolytic lectin CEL-III isolated from the marine invertebrate Cucumaria echinata: implications of domain structure for its membrane pore-formation mechanism."
    Uchida T., Yamasaki T., Eto S., Sugawara H., Kurisu G., Nakagawa A., Kusunoki M., Hatakeyama T.
    J. Biol. Chem. 279:37133-37141(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM, ACTIVE SITE, AND PYRROLIDONE CARBOXYLIC ACID AT GLN-11.
  4. "C-type lectin-like carbohydrate recognition of the hemolytic lectin CEL-III containing ricin-type -trefoil folds."
    Hatakeyama T., Unno H., Kouzuma Y., Uchida T., Eto S., Hidemura H., Kato N., Yonekura M., Kusunoki M.
    J. Biol. Chem. 282:37826-37835(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM, ACTIVE SITE.

Entry informationi

Entry nameiQ868M7_CUCEC
AccessioniPrimary (citable) accession number: Q868M7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3