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Q868M7

- Q868M7_CUCEC

UniProt

Q868M7 - Q868M7_CUCEC

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Protein
Submitted name: Hemolytic lectin CEL-III
Gene
cel3
Organism
Cucumaria echinata (Sea cucumber)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191N-acetyl-D-galactosamine
Metal bindingi33 – 331Calcium 1Imported
Metal bindingi34 – 341Calcium 1; via carbonyl oxygenImported
Metal bindingi36 – 361Calcium 1; via carbonyl oxygenImported
Metal bindingi42 – 421Magnesium 1Imported
Metal bindingi43 – 431Magnesium 1; via amide nitrogen and carbonyl oxygenImported
Metal bindingi53 – 531Calcium 1Imported
Metal bindingi82 – 821Magnesium 1Imported
Metal bindingi83 – 831Magnesium 1; via carbonyl oxygenImported
Binding sitei117 – 1171N-acetyl-D-galactosamine; via carbonyl oxygen
Metal bindingi131 – 1311Calcium 2Imported
Metal bindingi134 – 1341Calcium 2Imported
Metal bindingi137 – 1371Calcium 3; via amide nitrogen and carbonyl oxygenImported
Metal bindingi138 – 1381Calcium 3Imported
Metal bindingi140 – 1401Magnesium 1Imported
Metal bindingi141 – 1411Magnesium 1Imported
Metal bindingi147 – 1471Calcium 2Imported
Binding sitei147 – 1471N-acetyl-D-galactosamine
Metal bindingi151 – 1511Calcium 2Imported
Metal bindingi178 – 1781Calcium 4Imported
Metal bindingi179 – 1791Calcium 4; via carbonyl oxygenImported
Metal bindingi181 – 1811Calcium 4; via carbonyl oxygenImported
Metal bindingi187 – 1871Magnesium 2Imported
Metal bindingi188 – 1881Magnesium 2; via carbonyl oxygenImported
Metal bindingi198 – 1981Calcium 4Imported
Metal bindingi219 – 2191Calcium 5Imported
Metal bindingi220 – 2201Calcium 5; via carbonyl oxygenImported
Metal bindingi222 – 2221Calcium 5; via carbonyl oxygenImported
Metal bindingi228 – 2281Magnesium 2Imported
Metal bindingi229 – 2291Magnesium 2; via carbonyl oxygenImported
Binding sitei232 – 2321N-acetyl-D-galactosamine
Metal bindingi239 – 2391Calcium 5Imported
Metal bindingi266 – 2661Calcium 6Imported
Metal bindingi267 – 2671Calcium 6; via carbonyl oxygenImported
Metal bindingi269 – 2691Calcium 6; via carbonyl oxygenImported
Metal bindingi275 – 2751Magnesium 2Imported
Metal bindingi276 – 2761Magnesium 2; via carbonyl oxygenImported
Metal bindingi286 – 2861Calcium 6Imported
Metal bindingi383 – 3831Calcium 7Imported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

CalciumImported, LectinImported, MagnesiumImported, Metal-bindingImported

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Hemolytic lectin CEL-IIIImported
Gene namesi
Name:cel3Imported
OrganismiCucumaria echinata (Sea cucumber)Imported
Taxonomic identifieri40245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaDendrochirotaceaDendrochirotidaCucumariidaeCucumaria

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111Pyrrolidone carboxylic acidImported

Keywords - PTMi

Pyrrolidone carboxylic acidImported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VCLX-ray1.70A/B11-442[»]
2Z48X-ray1.70A/B11-442[»]
2Z49X-ray1.95A/B12-442[»]
3W9TX-ray2.90A/B/C/D/E/F/G12-442[»]
ProteinModelPortaliQ868M7.
SMRiQ868M7. Positions 12-442.

Miscellaneous databases

EvolutionaryTraceiQ868M7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 1344N-acetyl-D-galactosamine binding
Regioni178 – 1792N-acetyl-D-galactosamine binding
Regioni191 – 1944N-acetyl-D-galactosamine binding
Regioni219 – 2202N-acetyl-D-galactosamine binding

Family and domain databases

Gene3Di3.30.1750.10. 1 hit.
InterProiIPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
[Graphical view]
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q868M7-1 [UniParc]FASTAAdd to Basket

« Hide

MVSLVPCGFA QVLCTNPLDI GELRNYKSKQ CVDIVGNQGS GNIATHDCDG    50
LSDQQIIMCG DGTIRNEARN YCFTPDGSGN ANVMSSPCTL YPEIPSSQRW 100
RLGRKKAFTD NGGIEQVATE IINLASGKCL DVEGSDGTGD IGVYDCQNLD 150
DQYFYIRSRG PELFYGRLRN EKSDLCLDVE GSEGKGNVLM YSCEDNLDQW 200
FRYYENGEIV NAKQGMCLDV EGSDGSGNVG IYRCDDLRDQ MWSRPNAYCN 250
GDYCSFLNKE SNKCLDVSGD QGTGDVGTWQ CDGLPDQRFK WVFDDWEVPT 300
ATWNMVGCDQ NGKVSQQISN TISFSSTVTA GVAVEVSSTI EKGVIFAKAS 350
VSVKVTASLS KAWTNSQSGT TAITYTCDNY DSDEEFTRGC MWQLAIETTE 400
VKSGDLLVWN PQIIKCTRSN TAPGCAPFTK CANEDCTFCT DI 442
Length:442
Mass (Da):48,456
Last modified:June 1, 2003 - v1
Checksum:i3E47C608446D40EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB109017 mRNA. Translation: BAC75827.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB109017 mRNA. Translation: BAC75827.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VCL X-ray 1.70 A/B 11-442 [» ]
2Z48 X-ray 1.70 A/B 11-442 [» ]
2Z49 X-ray 1.95 A/B 12-442 [» ]
3W9T X-ray 2.90 A/B/C/D/E/F/G 12-442 [» ]
ProteinModelPortali Q868M7.
SMRi Q868M7. Positions 12-442.
ModBasei Search...

Protein family/group databases

CAZyi CBM13. Carbohydrate-Binding Module Family 13.
TCDBi 1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q868M7.

Family and domain databases

Gene3Di 3.30.1750.10. 1 hit.
InterProi IPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00652. Ricin_B_lectin. 2 hits.
[Graphical view ]
SMARTi SM00458. RICIN. 2 hits.
[Graphical view ]
SUPFAMi SSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEi PS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of hemolytic lectin CEL-III from marine invertebrate Cucumaria echinata and its cDNA: structural similarity to the B-chain from plant lectin, ricin."
    Nakano M., Tabata S., Sugihara K., Kouzuma Y., Kimura M., Yamasaki N.
    Biochim. Biophys. Acta 1435:167-176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Kouzuma Y.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Crystal structure of the hemolytic lectin CEL-III isolated from the marine invertebrate Cucumaria echinata: implications of domain structure for its membrane pore-formation mechanism."
    Uchida T., Yamasaki T., Eto S., Sugawara H., Kurisu G., Nakagawa A., Kusunoki M., Hatakeyama T.
    J. Biol. Chem. 279:37133-37141(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM, CARBOXYLATION AT GLN-11.
  4. "C-type lectin-like carbohydrate recognition of the hemolytic lectin CEL-III containing ricin-type -trefoil folds."
    Hatakeyama T., Unno H., Kouzuma Y., Uchida T., Eto S., Hidemura H., Kato N., Yonekura M., Kusunoki M.
    J. Biol. Chem. 282:37826-37835(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM.

Entry informationi

Entry nameiQ868M7_CUCEC
AccessioniPrimary (citable) accession number: Q868M7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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