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Q868M7

- Q868M7_CUCEC

UniProt

Q868M7 - Q868M7_CUCEC

Protein
Submitted name:

Hemolytic lectin CEL-III

Gene

cel3

Organism
Cucumaria echinata (Sea cucumber)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191N-acetyl-D-galactosamine
    Metal bindingi33 – 331Calcium 1Imported
    Metal bindingi34 – 341Calcium 1; via carbonyl oxygenImported
    Metal bindingi36 – 361Calcium 1; via carbonyl oxygenImported
    Metal bindingi42 – 421Magnesium 1Imported
    Metal bindingi43 – 431Magnesium 1; via amide nitrogen and carbonyl oxygenImported
    Metal bindingi53 – 531Calcium 1Imported
    Metal bindingi82 – 821Magnesium 1Imported
    Metal bindingi83 – 831Magnesium 1; via carbonyl oxygenImported
    Binding sitei117 – 1171N-acetyl-D-galactosamine; via carbonyl oxygen
    Metal bindingi131 – 1311Calcium 2Imported
    Metal bindingi134 – 1341Calcium 2Imported
    Metal bindingi137 – 1371Calcium 3; via amide nitrogen and carbonyl oxygen
    Metal bindingi138 – 1381Calcium 3
    Metal bindingi140 – 1401Magnesium 1
    Metal bindingi141 – 1411Magnesium 1Imported
    Metal bindingi147 – 1471Calcium 2
    Binding sitei147 – 1471N-acetyl-D-galactosamine
    Metal bindingi151 – 1511Calcium 2Imported
    Metal bindingi178 – 1781Calcium 4Imported
    Metal bindingi179 – 1791Calcium 4; via carbonyl oxygenImported
    Metal bindingi181 – 1811Calcium 4; via carbonyl oxygenImported
    Metal bindingi187 – 1871Magnesium 2Imported
    Metal bindingi188 – 1881Magnesium 2; via carbonyl oxygenImported
    Metal bindingi198 – 1981Calcium 4Imported
    Metal bindingi219 – 2191Calcium 5Imported
    Metal bindingi220 – 2201Calcium 5; via carbonyl oxygenImported
    Metal bindingi222 – 2221Calcium 5; via carbonyl oxygenImported
    Metal bindingi228 – 2281Magnesium 2Imported
    Metal bindingi229 – 2291Magnesium 2; via carbonyl oxygenImported
    Binding sitei232 – 2321N-acetyl-D-galactosamine
    Metal bindingi239 – 2391Calcium 5Imported
    Metal bindingi266 – 2661Calcium 6Imported
    Metal bindingi267 – 2671Calcium 6; via carbonyl oxygenImported
    Metal bindingi269 – 2691Calcium 6; via carbonyl oxygenImported
    Metal bindingi275 – 2751Magnesium 2Imported
    Metal bindingi276 – 2761Magnesium 2; via carbonyl oxygenImported
    Metal bindingi286 – 2861Calcium 6Imported
    Metal bindingi383 – 3831Calcium 7

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    CalciumImported, LectinImported, MagnesiumImported, Metal-bindingImported

    Protein family/group databases

    CAZyiCBM13. Carbohydrate-Binding Module Family 13.
    TCDBi1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hemolytic lectin CEL-IIIImported
    Gene namesi
    Name:cel3Imported
    OrganismiCucumaria echinata (Sea cucumber)Imported
    Taxonomic identifieri40245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaDendrochirotaceaDendrochirotidaCucumariidaeCucumaria

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111Pyrrolidonecarboxylic acidImported

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VCLX-ray1.70A/B11-442[»]
    2Z48X-ray1.70A/B11-442[»]
    2Z49X-ray1.95A/B12-442[»]
    3W9TX-ray2.90A/B/C/D/E/F/G12-442[»]
    ProteinModelPortaliQ868M7.
    SMRiQ868M7. Positions 12-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ868M7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 1344N-acetyl-D-galactosamine binding
    Regioni178 – 1792N-acetyl-D-galactosamine binding
    Regioni191 – 1944N-acetyl-D-galactosamine binding
    Regioni219 – 2202N-acetyl-D-galactosamine binding

    Family and domain databases

    Gene3Di3.30.1750.10. 1 hit.
    InterProiIPR028988. CEL-III_C.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF00652. Ricin_B_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00458. RICIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF111265. SSF111265. 1 hit.
    SSF50370. SSF50370. 2 hits.
    PROSITEiPS50231. RICIN_B_LECTIN. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q868M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSLVPCGFA QVLCTNPLDI GELRNYKSKQ CVDIVGNQGS GNIATHDCDG    50
    LSDQQIIMCG DGTIRNEARN YCFTPDGSGN ANVMSSPCTL YPEIPSSQRW 100
    RLGRKKAFTD NGGIEQVATE IINLASGKCL DVEGSDGTGD IGVYDCQNLD 150
    DQYFYIRSRG PELFYGRLRN EKSDLCLDVE GSEGKGNVLM YSCEDNLDQW 200
    FRYYENGEIV NAKQGMCLDV EGSDGSGNVG IYRCDDLRDQ MWSRPNAYCN 250
    GDYCSFLNKE SNKCLDVSGD QGTGDVGTWQ CDGLPDQRFK WVFDDWEVPT 300
    ATWNMVGCDQ NGKVSQQISN TISFSSTVTA GVAVEVSSTI EKGVIFAKAS 350
    VSVKVTASLS KAWTNSQSGT TAITYTCDNY DSDEEFTRGC MWQLAIETTE 400
    VKSGDLLVWN PQIIKCTRSN TAPGCAPFTK CANEDCTFCT DI 442
    Length:442
    Mass (Da):48,456
    Last modified:June 1, 2003 - v1
    Checksum:i3E47C608446D40EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB109017 mRNA. Translation: BAC75827.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB109017 mRNA. Translation: BAC75827.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VCL X-ray 1.70 A/B 11-442 [» ]
    2Z48 X-ray 1.70 A/B 11-442 [» ]
    2Z49 X-ray 1.95 A/B 12-442 [» ]
    3W9T X-ray 2.90 A/B/C/D/E/F/G 12-442 [» ]
    ProteinModelPortali Q868M7.
    SMRi Q868M7. Positions 12-442.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM13. Carbohydrate-Binding Module Family 13.
    TCDBi 1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q868M7.

    Family and domain databases

    Gene3Di 3.30.1750.10. 1 hit.
    InterProi IPR028988. CEL-III_C.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF00652. Ricin_B_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00458. RICIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF111265. SSF111265. 1 hit.
    SSF50370. SSF50370. 2 hits.
    PROSITEi PS50231. RICIN_B_LECTIN. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of hemolytic lectin CEL-III from marine invertebrate Cucumaria echinata and its cDNA: structural similarity to the B-chain from plant lectin, ricin."
      Nakano M., Tabata S., Sugihara K., Kouzuma Y., Kimura M., Yamasaki N.
      Biochim. Biophys. Acta 1435:167-176(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Kouzuma Y.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Crystal structure of the hemolytic lectin CEL-III isolated from the marine invertebrate Cucumaria echinata: implications of domain structure for its membrane pore-formation mechanism."
      Uchida T., Yamasaki T., Eto S., Sugawara H., Kurisu G., Nakagawa A., Kusunoki M., Hatakeyama T.
      J. Biol. Chem. 279:37133-37141(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM, PYRROLIDONECARBOXYLIC ACID AT GLN-11.
    4. "C-type lectin-like carbohydrate recognition of the hemolytic lectin CEL-III containing ricin-type -trefoil folds."
      Hatakeyama T., Unno H., Kouzuma Y., Uchida T., Eto S., Hidemura H., Kato N., Yonekura M., Kusunoki M.
      J. Biol. Chem. 282:37826-37835(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 11-442 IN COMPLEX WITH CALCIUM AND MAGNESIUM.

    Entry informationi

    Entry nameiQ868M7_CUCEC
    AccessioniPrimary (citable) accession number: Q868M7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3