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Protein
Submitted name:

Hemolytic lectin CEL-III

Gene

cel3

Organism
Cucumaria echinata (Sea cucumber)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33Calcium 1Combined sources1
Metal bindingi34Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi36Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi42Magnesium 1Combined sources1
Metal bindingi43Magnesium 1; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi53Calcium 1Combined sources1
Metal bindingi82Magnesium 1Combined sources1
Metal bindingi83Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi131Calcium 2Combined sources1
Metal bindingi134Calcium 2Combined sources1
Metal bindingi137Calcium 3; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi138Calcium 3Combined sources1
Metal bindingi140Magnesium 1Combined sources1
Metal bindingi141Magnesium 1Combined sources1
Metal bindingi147Calcium 2Combined sources1
Metal bindingi151Calcium 2Combined sources1
Metal bindingi178Calcium 4Combined sources1
Metal bindingi179Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi181Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi187Magnesium 2Combined sources1
Metal bindingi188Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi198Calcium 4Combined sources1
Metal bindingi219Calcium 5Combined sources1
Metal bindingi220Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi222Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi228Magnesium 2Combined sources1
Metal bindingi229Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi239Calcium 5Combined sources1
Metal bindingi266Calcium 6Combined sources1
Metal bindingi267Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi269Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi275Magnesium 2Combined sources1
Metal bindingi276Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi286Calcium 6Combined sources1
Metal bindingi383Calcium 7Combined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, LectinImported, MagnesiumCombined sources, Metal-bindingCombined sources

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Hemolytic lectin CEL-IIIImported
Gene namesi
Name:cel3Imported
OrganismiCucumaria echinata (Sea cucumber)Imported
Taxonomic identifieri40245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaDendrochirotaceaDendrochirotidaCucumariidaeCucumaria

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Pyrrolidone carboxylic acidCombined sources1
Disulfide bondi14 ↔ 59Combined sources
Disulfide bondi31 ↔ 48Combined sources
Disulfide bondi72 ↔ 88Combined sources
Disulfide bondi129 ↔ 146Combined sources
Disulfide bondi176 ↔ 193Combined sources
Disulfide bondi217 ↔ 234Combined sources
Disulfide bondi249 ↔ 254Combined sources
Disulfide bondi264 ↔ 281Combined sources
Disulfide bondi308 ↔ 390Combined sources
Disulfide bondi377 ↔ 416Combined sources
Disulfide bondi425 ↔ 439Combined sources
Disulfide bondi431 ↔ 436Combined sources

Keywords - PTMi

Pyrrolidone carboxylic acidCombined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCLX-ray1.70A/B11-442[»]
2Z48X-ray1.70A/B11-442[»]
2Z49X-ray1.95A/B12-442[»]
3W9TX-ray2.90A/B/C/D/E/F/G12-442[»]
ProteinModelPortaliQ868M7.
SMRiQ868M7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ868M7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 102Ricin B-type lectinInterPro annotationAdd BLAST75
Domaini115 – 245Ricin B-type lectinInterPro annotationAdd BLAST131
Domaini261 – 293Ricin B-type lectinInterPro annotationAdd BLAST33

Family and domain databases

Gene3Di3.30.1750.10. 1 hit.
InterProiIPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
[Graphical view]
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q868M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLVPCGFA QVLCTNPLDI GELRNYKSKQ CVDIVGNQGS GNIATHDCDG
60 70 80 90 100
LSDQQIIMCG DGTIRNEARN YCFTPDGSGN ANVMSSPCTL YPEIPSSQRW
110 120 130 140 150
RLGRKKAFTD NGGIEQVATE IINLASGKCL DVEGSDGTGD IGVYDCQNLD
160 170 180 190 200
DQYFYIRSRG PELFYGRLRN EKSDLCLDVE GSEGKGNVLM YSCEDNLDQW
210 220 230 240 250
FRYYENGEIV NAKQGMCLDV EGSDGSGNVG IYRCDDLRDQ MWSRPNAYCN
260 270 280 290 300
GDYCSFLNKE SNKCLDVSGD QGTGDVGTWQ CDGLPDQRFK WVFDDWEVPT
310 320 330 340 350
ATWNMVGCDQ NGKVSQQISN TISFSSTVTA GVAVEVSSTI EKGVIFAKAS
360 370 380 390 400
VSVKVTASLS KAWTNSQSGT TAITYTCDNY DSDEEFTRGC MWQLAIETTE
410 420 430 440
VKSGDLLVWN PQIIKCTRSN TAPGCAPFTK CANEDCTFCT DI
Length:442
Mass (Da):48,456
Last modified:June 1, 2003 - v1
Checksum:i3E47C608446D40EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109017 mRNA. Translation: BAC75827.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109017 mRNA. Translation: BAC75827.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCLX-ray1.70A/B11-442[»]
2Z48X-ray1.70A/B11-442[»]
2Z49X-ray1.95A/B12-442[»]
3W9TX-ray2.90A/B/C/D/E/F/G12-442[»]
ProteinModelPortaliQ868M7.
SMRiQ868M7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.
TCDBi1.C.96.1.1. the haemolytic lectin, cel-iii (cel-iii) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ868M7.

Family and domain databases

Gene3Di3.30.1750.10. 1 hit.
InterProiIPR028988. CEL-III_C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00652. Ricin_B_lectin. 2 hits.
[Graphical view]
SMARTiSM00458. RICIN. 2 hits.
[Graphical view]
SUPFAMiSSF111265. SSF111265. 1 hit.
SSF50370. SSF50370. 2 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ868M7_CUCEC
AccessioniPrimary (citable) accession number: Q868M7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.