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Protein

Tachykinins

Gene

Atk

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Associated with sex-specific or age/division of labor-selective behavior and/or physiology of honeybees.Curated1 Publication

GO - Molecular functioni

  • neurotransmitter transporter activity Source: UniProtKB

GO - Biological processi

  • behavior Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB-KW
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • tachykinin receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter
Biological processBehavior

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinins
Alternative name(s):
AmTRP
Tachykinin-related peptide
Cleaved into the following 19 chains:
Alternative name(s):
AmTRP1
Tachykinin-related peptide 1
Short name:
TRP1
Alternative name(s):
AmTRP2
Tachykinin-related peptide 2
Short name:
TRP2
Alternative name(s):
AmTRP3
Tachykinin-related peptide 3-1
Short name:
TRP3-1
Alternative name(s):
AmTRP3
Tachykinin-related peptide 3-2
Short name:
TRP3-2
Alternative name(s):
AmTAP1
Tachykinin-associated peptide 1
Alternative name(s):
AmTRP4
Tachykinin-related peptide 4
Short name:
TRP4
Alternative name(s):
AmTRP5
Tachykinin-related peptide 5
Short name:
TRP5
Alternative name(s):
AmTRP6
Tachykinin-related peptide 6
Short name:
TRP6
Alternative name(s):
AmTRP7
Tachykinin-related peptide 7
Short name:
TRP7
Gene namesi
Name:AtkImported
Synonyms:TK1 Publication
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000034346419 – 27Sequence analysis1 Publication9
PeptideiPRO_000034346530 – 38APTGHQEMQ-amide1 Publication9
PropeptideiPRO_000034346641 – 541 PublicationAdd BLAST14
PeptideiPRO_000034346757 – 65ALMGFQGVR-amide1 Publication9
PeptideiPRO_000034346869 – 85Brain peptide NSIINDVKNELFPEDINAdd BLAST17
PeptideiPRO_000034346988 – 96APMGFQGMR-amide 11 Publication9
PeptideiPRO_0000343470100 – 107Brain peptide ASFDDEYY8
PeptideiPRO_0000343471110 – 118APMGFQGMR-amide 21 Publication9
PeptideiPRO_0000343472122 – 131Brain peptide SLEEILDEIK10
PeptideiPRO_0000343473122 – 130Brain peptide SLEEILDEI9
PeptideiPRO_0000343474125 – 130Brain peptide EILDEI6
PeptideiPRO_0000343475134 – 154TTRFQDSRSKDVYLIDYPEDY-amide1 PublicationAdd BLAST21
PeptideiPRO_0000343476158 – 179Brain peptide VLSMDGYQNILDKKDELLGEWEAdd BLAST22
PeptideiPRO_0000343477182 – 190APMGFYGTR-amide1 Publication9
PeptideiPRO_0000343478182 – 189Brain peptide APMGFYGT8
PeptideiPRO_0000343479194 – 203Brain peptide IILDALEELD10
PeptideiPRO_0000343480195 – 203Brain peptide ILDALEELD9
PeptideiPRO_0000343481206 – 215Brain peptide GVMDFQIGLQ10
PropeptideiPRO_0000343482219 – 2521 PublicationAdd BLAST34
PeptideiPRO_0000343483255 – 263ARMGFHGMR-amide1 Publication9
PropeptideiPRO_0000343484267 – 3011 PublicationAdd BLAST35
PeptideiPRO_0000343485304 – 312SPFRYLGAR-amide1 Publication9
PeptideiPRO_0000343486316 – 329NPRWEFRGKFVGVR-amide1 PublicationAdd BLAST14
PropeptideiPRO_0000343487333 – 3391 Publication7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Glutamine amide1 Publication1
Modified residuei65Arginine amide1 Publication1
Modified residuei96Arginine amide1 Publication1
Modified residuei118Arginine amide1 Publication1
Modified residuei154Tyrosine amide1 Publication1
Modified residuei190Arginine amide1 Publication1
Modified residuei263Arginine amide1 Publication1
Modified residuei312Arginine amide1 Publication1
Modified residuei329Arginine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ868G6.

Expressioni

Tissue specificityi

Strong expression was detected in the queen and forager heads, while weak and almost no significant expression was detected in the nurse and drone heads, respectively.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7460.GB12290-PA.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J6T4. Eukaryota.
ENOG410XYA8. LUCA.
InParanoidiQ868G6.
PhylomeDBiQ868G6.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q868G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIHSIFLLM VSITLVIAEE SDNVLFDKRA PTGHQEMQGK QNSASLNSEN
60 70 80 90 100
FGIFKRALMG FQGVRGKKNS IINDVKNELF PEDINKRAPM GFQGMRGKKA
110 120 130 140 150
SFDDEYYKRA PMGFQGMRGK KSLEEILDEI KKKTTRFQDS RSKDVYLIDY
160 170 180 190 200
PEDYGKRVLS MDGYQNILDK KDELLGEWEK RAPMGFYGTR GKKIILDALE
210 220 230 240 250
ELDKRGVMDF QIGLQRKKDT TFDDYLDYAI NPFDYEKRST DFQDVESGSE
260 270 280 290 300
SFKRARMGFH GMRGKRDAAG IYGSNSSTVG TIFGYQDMRN RGNNFPVYQV
310 320 330
EKRSPFRYLG ARGKKNPRWE FRGKFVGVRG KKSSLQTVF
Length:339
Mass (Da):39,039
Last modified:June 1, 2003 - v1
Checksum:iE6C10381B76C77EE
GO

Sequence cautioni

The sequence BAC76399 differs from that shown. Intron retention.Curated
The sequence BAC76400 differs from that shown. Intron retention.Curated
The sequence BAC76401 differs from that shown. Intron retention.Curated
The sequence BAC76401 differs from that shown. Reason: Frameshift at position 123.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 7IF → TL in BAC76401 (PubMed:12752663).Curated2
Sequence conflicti41Q → EK in BAC76401 (PubMed:12752663).Curated1

Mass spectrometryi

Molecular mass is 976.53 Da from positions 57 - 65. Determined by ESI. 1 Publication
Molecular mass is 976.53 Da from positions 57 - 65. Determined by MALDI. 1 Publication
Molecular mass is 1034.54 Da from positions 57 - 66. Determined by ESI. Includes unconverted Gly.1 Publication
Molecular mass is 1972.97 Da from positions 69 - 85. Determined by ESI. 1 Publication
Molecular mass is 1972.97 Da from positions 69 - 85. Determined by MALDI. 1 Publication
Molecular mass is 992.47 Da from positions 88 - 96. Determined by ESI. 2 Publications
Molecular mass is 992.47 Da from positions 88 - 96. Determined by MALDI. 2 Publications
Molecular mass is 993.9 Da from positions 88 - 96. Determined by MALDI. 2 Publications
Molecular mass is 1050.47 Da from positions 88 - 97. Determined by ESI. Includes unconverted Gly.1 Publication
Molecular mass is 1008.38 Da from positions 100 - 107. Determined by ESI. 1 Publication
Molecular mass is 992.47 Da from positions 110 - 118. Determined by MALDI. 2 Publications
Molecular mass is 992.47 Da from positions 110 - 118. Determined by ESI. 2 Publications
Molecular mass is 993.9 Da from positions 110 - 118. Determined by MALDI. 2 Publications
Molecular mass is 1050.47 Da from positions 110 - 119. Determined by ESI. Includes unconverted Gly.1 Publication
Molecular mass is 1059.54 Da from positions 122 - 130. Determined by ESI. Incompletely processed peptide.1 Publication
Molecular mass is 1187.63 Da from positions 122 - 131. Determined by ESI. 1 Publication
Molecular mass is 1187.63 Da from positions 122 - 131. Determined by MALDI. 1 Publication
Molecular mass is 730.38 Da from positions 125 - 130. Determined by ESI. Partial peptide processing.1 Publication
Molecular mass is 2609.24 Da from positions 134 - 154. Determined by ESI. 1 Publication
Molecular mass is 2594.26 Da from positions 158 - 179. Determined by ESI. 1 Publication
Molecular mass is 842.36 Da from positions 182 - 189. Determined by ESI. Partial peptide processing.1 Publication
Molecular mass is 997.48 Da from positions 182 - 190. Determined by ESI. 1 Publication
Molecular mass is 997.48 Da from positions 182 - 190. Determined by MALDI. 1 Publication
Molecular mass is 1055.49 Da from positions 182 - 191. Determined by ESI. Includes unconverted Gly.1 Publication
Molecular mass is 1055.49 Da from positions 182 - 191. Determined by MALDI. Includes unconverted Gly.1 Publication
Molecular mass is 1142.61 Da from positions 194 - 203. Determined by ESI. 1 Publication
Molecular mass is 1029.50 Da from positions 195 - 203. Determined by ESI. Partial peptide processing.1 Publication
Molecular mass is 1106.55 Da from positions 206 - 215. Determined by ESI. 1 Publication
Molecular mass is 1060.52 Da from positions 255 - 263. Determined by MALDI. 1 Publication
Molecular mass is 1064.59 Da from positions 304 - 312. Determined by ESI. 1 Publication
Molecular mass is 1064.59 Da from positions 304 - 312. Determined by MALDI. 1 Publication
Molecular mass is 1745.96 Da from positions 316 - 329. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073995 mRNA. Translation: BAC76399.1. Sequence problems.
AB073996 mRNA. Translation: BAC76400.1. Sequence problems.
AB073997 mRNA. Translation: BAC76401.1. Sequence problems.
AB073998 mRNA. Translation: BAC76402.1.
RefSeqiNP_001011576.1. NM_001011576.1.
UniGeneiAme.200.

Genome annotation databases

GeneIDi406083.
KEGGiame:406083.

Similar proteinsi

Entry informationi

Entry nameiTACHY_APIME
AccessioniPrimary (citable) accession number: Q868G6
Secondary accession number(s): Q86DQ5, Q86DQ6, Q86DQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: April 12, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families