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Protein

Superoxide-generating NADPH oxidase light chain subunit

Gene

cybA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.By similarity

GO - Molecular functioni

GO - Biological processi

  • sorocarp development Source: dictyBase
  • superoxide anion generation Source: GO_Central
  • superoxide metabolic process Source: dictyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide-generating NADPH oxidase light chain subunit
Alternative name(s):
Cytochrome b-245 light chain
p22-phox
Short name:
p22phox
Gene namesi
Name:cybA
ORF Names:DDB_G0267460
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0267460. cybA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: dictyBase
  • NADPH oxidase complex Source: dictyBase

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Prevents formation of fruiting bodies.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615301 – 118Superoxide-generating NADPH oxidase light chain subunitAdd BLAST118

Proteomic databases

PaxDbiQ867X6.

Expressioni

Developmental stagei

Expressed during vegetative stage. Expression decreases during development and disappears from 8 hours.1 Publication

Interactioni

Subunit structurei

Composed of a heavy chain and a light chain.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0191314.

Family & Domainsi

Sequence similaritiesi

Belongs to the p22phox family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ867X6.
KOiK08009.
OMAiMIGMAAC.
PhylomeDBiQ867X6.

Family and domain databases

InterProiView protein in InterPro
IPR007732. Cyt_b558_asu.
PANTHERiPTHR15168. PTHR15168. 1 hit.
PfamiView protein in Pfam
PF05038. Cytochrom_B558a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q867X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKFKLGNWA AMIGMAACWC LIAGGIMGIW YERRYIAIYS ICVGGVLYPL
60 70 80 90 100
LYPLSFLGPL KAIFHQYYVA AALMAGLSVL CYFLVPTMLA AMVMDISAVV
110
FLISAIKGER GDFFDKQD
Length:118
Mass (Da):13,008
Last modified:June 1, 2003 - v1
Checksum:i2F07828020A16DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221170 mRNA. Translation: AAO62418.1.
AY221171 Genomic DNA. Translation: AAO62419.1.
AAFI02000003 Genomic DNA. Translation: EAL73183.1.
RefSeqiXP_647140.1. XM_642048.1.

Genome annotation databases

EnsemblProtistsiEAL73183; EAL73183; DDB_G0267460.
GeneIDi8615943.
KEGGiddi:DDB_G0267460.

Similar proteinsi

Entry informationi

Entry nameiCY24A_DICDI
AccessioniPrimary (citable) accession number: Q867X6
Secondary accession number(s): Q55GP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families