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Q867X3

- ACES_CULPP

UniProt

Q867X3 - ACES_CULPP

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Protein

Acetylcholinesterase

Gene

ACE-1

Organism
Culex pipiens pipiens (Northern house mosquito)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Rapidly hydrolyzes choline released into the synapse.Curated

Catalytic activityi

Acetylcholine + H2O = choline + acetate.By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ACE-1
OrganismiCulex pipiens pipiens (Northern house mosquito)Imported
Taxonomic identifieri38569 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

Subcellular locationi

Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›132›132AcetylcholinesterasePRO_0000070280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi45 ↔ 72By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ867X3.
SMRiQ867X3. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q867X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SGKKVDAWMG IPYAQPPLGP LRFRHPRPAE RWTGVLNATK PPNSCVQIVD
60 70 80 90 100
TVFGDFPGAT MWNPNTPLSE DCLYINVVVP RPRPKNAAVM LWIFGGGFYS
110 120 130
GTATLDVYDH RTLASEENVI VVSLQYRVAS LG
Length:132
Mass (Da):14,543
Last modified:June 1, 2003 - v1
Checksum:i2F40C4B3FC2468E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei132 – 1321Imported

Polymorphismi

A number of strains are susceptible to insecticides while others are resistant. Insensitivity to insecticides results from a loss of sensitivity of acetylcholinesterase to organophosphates and carbamates and is due to a variant at position 97.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971G → S in strain: Barriol, Espro, Padova and Praias. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512688 Genomic DNA. Translation: CAD54760.1.
AJ512690 Genomic DNA. Translation: CAD54762.1.
AJ512695 Genomic DNA. Translation: CAD54767.1.
AJ512696 Genomic DNA. Translation: CAD54768.1.
AJ512699 Genomic DNA. Translation: CAD54771.1.
AJ512701 Genomic DNA. Translation: CAD54773.1.
AJ512702 Genomic DNA. Translation: CAD54774.1.
AJ512708 Genomic DNA. Translation: CAD54780.1.
AJ512709 Genomic DNA. Translation: CAD54781.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512688 Genomic DNA. Translation: CAD54760.1 .
AJ512690 Genomic DNA. Translation: CAD54762.1 .
AJ512695 Genomic DNA. Translation: CAD54767.1 .
AJ512696 Genomic DNA. Translation: CAD54768.1 .
AJ512699 Genomic DNA. Translation: CAD54771.1 .
AJ512701 Genomic DNA. Translation: CAD54773.1 .
AJ512702 Genomic DNA. Translation: CAD54774.1 .
AJ512708 Genomic DNA. Translation: CAD54780.1 .
AJ512709 Genomic DNA. Translation: CAD54781.1 .

3D structure databases

ProteinModelPortali Q867X3.
SMRi Q867X3. Positions 2-132.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BarriolImported, BleuetImported, BrugesAImported, BrugesBImported, EsproImported, HeterenImported, KillcareImported, PadovaImported and PraiasImported.

Entry informationi

Entry nameiACES_CULPP
AccessioniPrimary (citable) accession number: Q867X3
Secondary accession number(s): Q867X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3