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Protein

NADPH oxidase activator

Gene

ncfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an activator of NOX1, a superoxide-producing NADPH oxidase.By similarity

Miscellaneous

Although it only shares low sequence similarity with members of the NCF2/NOXA1 family, it may ensure the same function as NCF2/p67-phox.

GO - Molecular functioni

  • superoxide-generating NADPH oxidase activator activity Source: dictyBase

GO - Biological processi

  • superoxide metabolic process Source: dictyBase

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH oxidase activator
Short name:
NOX activator
Alternative name(s):
p67-phox-like factor
Gene namesi
Name:ncfA
ORF Names:DDB_G0288773
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288773. ncfA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615311 – 604NADPH oxidase activatorAdd BLAST604

Proteomic databases

PaxDbiQ867T7.

Expressioni

Developmental stagei

Highly expressed during vegetative stage. Expression decreases during development and is very low from 12 hours (late aggregation stage).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191152.

Structurei

3D structure databases

ProteinModelPortaliQ867T7.
SMRiQ867T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 69TPR 1Add BLAST34
Repeati71 – 103TPR 2Add BLAST33
Domaini309 – 384PB1PROSITE-ProRule annotationAdd BLAST76
Domaini573 – 604WWPROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 300Pro-richAdd BLAST96
Compositional biasi226 – 242Poly-SerAdd BLAST17
Compositional biasi260 – 277Poly-SerAdd BLAST18
Compositional biasi402 – 424Poly-SerAdd BLAST23
Compositional biasi446 – 453Poly-Thr8
Compositional biasi472 – 484Poly-SerAdd BLAST13
Compositional biasi485 – 489Poly-Gly5

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4225. Eukaryota.
ENOG41110AD. LUCA.
InParanoidiQ867T7.
OMAiHEYIDYK.

Family and domain databases

CDDicd00201. WW. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000270. PB1_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001202. WW_dom.
SMARTiView protein in SMART
SM00028. TPR. 2 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS51745. PB1. 1 hit.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q867T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQTIKKWN QSIERYESGN VGEALTILTS IEQSTSKINY NIGVMYIKSN
60 70 80 90 100
NFRNAIEYFN RSVEQDKYLA SSYYMRAIAH HMNGELNHAI VDYDETISKL
110 120 130 140 150
RGHEYIDYKQ LGLDHKLLLA EVLFNKALAL GRAGSSVALQ ATQCFSQPSD
160 170 180 190 200
SQEFKNQCKK IQDGSQLNFS TRPIPLSLLF KPPKVSDAPQ KQRSATTSSI
210 220 230 240 250
QSSSPSTPMS SSPPSYILKG PSSPPSSSSP SSSSPSLSSS SSPKLPPTPK
260 270 280 290 300
PSFGSSPPPS SSSSSSSSSS SSSSSISPLT NKTLPPKPPP LPSKKLPSRP
310 320 330 340 350
ISCVIQDVKI TLKVFYKDRR LIQIPVPCNL STFIQKIELK FEITISDKFS
360 370 380 390 400
LSFQLDGEEN EINSQVQLDK MICMEINEIN VKDIIPSPSP SPSPSPDKTN
410 420 430 440 450
NSTSSYSSSS SSSSSSSSSS SSSSYDNKPK SSFIPKTTTR PILPPTTTTT
460 470 480 490 500
TSTSNNFNRN ATLPKKFGST PSSPSFSSPS SSSSGGGGGP PIPTRGSPSI
510 520 530 540 550
SLLKQQNQTQ SINIPPKVPT SSRPKMTQSH SPPSSSPLSS YSTSFQSVSS
560 570 580 590 600
PSLSSSYNGS TSSYGGFSSS RPPPTPYPYQ VLYTDSNEKY YLNTETNETF

WELP
Length:604
Mass (Da):65,254
Last modified:June 1, 2003 - v1
Checksum:i503A267BA74F399E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY221172 Genomic DNA. Translation: AAO62420.1.
AY224389 mRNA. Translation: AAO72634.1.
AAFI02000125 Genomic DNA. Translation: EAL63008.1.
RefSeqiXP_636535.1. XM_631443.1.

Genome annotation databases

EnsemblProtistsiEAL63008; EAL63008; DDB_G0288773.
GeneIDi8626820.
KEGGiddi:DDB_G0288773.

Similar proteinsi

Entry informationi

Entry nameiNCFA_DICDI
AccessioniPrimary (citable) accession number: Q867T7
Secondary accession number(s): Q54IE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase