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Q867F4

- KA154_ANDAU

UniProt

Q867F4 - KA154_ANDAU

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Protein

Potassium channel toxin alpha-KTx 15.4

Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Blocker of A-type voltage-gated potassium channels of cerebellar granular cells. The occlusion of the outer entry of the K+ conducting pore is partially reversible and affects both open and closed channels. It shares the same target in rat brain that BmTX3 (M.martensii), and AmmTX3 (A.mauretanicus).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei49 – 491Basic residue of the functional dyadBy similarity
Sitei58 – 581Aromatic residue of the functional dyadBy similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 15.4
Short name:
AaTX1
Short name:
Toxin Aa1
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 5937Potassium channel toxin alpha-KTx 15.4PRO_0000035310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Pyrrolidone carboxylic acid1 Publication
Disulfide bondi30 ↔ 50By similarity
Disulfide bondi35 ↔ 55By similarity
Disulfide bondi39 ↔ 57By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ867F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
ProDomiPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q867F4 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKFSSIILLT LLICSMSIFG NCQIETNKKC QGGSCASVCR RVIGVAAGKC

INGRCVCYP
Length:59
Mass (Da):6,291
Last modified:June 1, 2003 - v1
Checksum:iE429B1B607A2F64E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241I → N AA sequence (PubMed:11018665)Curated

Mass spectrometryi

Molecular mass is 3850.83 Da from positions 23 - 59. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ427745 Genomic DNA. Translation: CAD20744.1.
AJ427743 mRNA. Translation: CAD20742.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ427745 Genomic DNA. Translation: CAD20744.1 .
AJ427743 mRNA. Translation: CAD20742.1 .

3D structure databases

ProteinModelPortali Q867F4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
ProDomi PD003586. Scorpion_toxinS. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterisation of the genes encoding Aa1 isoforms from the scorpion Androctonus australis."
    Legros C., Bougis P.E., Martin-Eauclaire M.-F.
    Toxicon 41:115-119(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Muscle and Venom gland.
  2. "Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom."
    Pisciotta M., Coronas F.I., Bloch C. Jr., Prestipino G., Possani L.D.
    Biochim. Biophys. Acta 1468:203-212(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-59, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-23, FUNCTION.
    Strain: Garzoni.
    Tissue: Venom.
  3. "Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus."
    Vacher H., Alami M., Crest M., Possani L.D., Bougis P.E., Martin-Eauclaire M.-F.
    Eur. J. Biochem. 269:6037-6041(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS OF 23-59, PHARMACOLOGICAL CHARACTERIZATION.

Entry informationi

Entry nameiKA154_ANDAU
AccessioniPrimary (citable) accession number: Q867F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3