Q867D0 (EDN2_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-2
Short name=ET-2

Alternative name(s):
Preproendothelin-2
Short name=PPET2

Gene names

Name:

EDN2

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location	Secreted.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vasoconstriction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Propeptide	25 – 46	22	By similarity		PRO_0000008087
	Peptide	49 – 69	21	Endothelin-2		PRO_0000008088
	Propeptide	70 – 178	109	By similarity		PRO_0000008089
Regions
	Region	96 – 111	16	Endothelin-like
Sites
	Site	69 – 70	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	49 ↔ 63		By similarity
	Disulfide bond	51 ↔ 59		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q867D0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 815C39BA0B891634	FASTA	178	19,795
	10 20 30 40 50 60 MVAMPPAWCS VALALLVALH EGEGQATATP EQPVPSPRAQ GSHLRPRRCS CSSWLDKECV 70 80 90 100 110 120 YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPRRCECSS ARDPACATFC HRRPWADAVA 130 140 150 160 170 VPGSDSPEDT FQAGKTWTTA GELLQQLRGI SAANIRFARR QQEAIRAPRP TPSRRRKR

References

[1]	"cDNA cloning, sequence analysis and organ distribution of horse preproendothelin-2." Uchide T., Fujimori Y., Temma K., Sasaki T., Kizaki K., Hara Y., Takizawa S., Saida K. J. Cardiovasc. Pharmacol. 44:S430-S434(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB079136 mRNA. Translation: BAC54893.1.
RefSeq	NP_001075292.1. NM_001081823.1.
UniGene	Eca.12912.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9796.ENSECAP00000020586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100033847.
KEGG	ecb:100033847.
Organism-specific databases
CTD	1907.
Phylogenomic databases
eggNOG	NOG43933.
HOGENOM	HOG000231110.
HOVERGEN	HBG051441.
InParanoid	Q867D0.
KO	K16367.
OrthoDB	EOG4WH8N0.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. IPR015658. ET-2. [Graphical view]
PANTHER	PTHR13874:SF4. PTHR13874:SF4. 1 hit.
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EDN2_HORSE

Accession

Primary (citable) accession number: Q867D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program