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Protein

Endothelin-2

Gene

EDN2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Gene namesi
Name:EDN2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000808725 – 46By similarityAdd BLAST22
PeptideiPRO_000000808849 – 69Endothelin-2Add BLAST21
PropeptideiPRO_000000808970 – 178By similarityAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 63By similarity
Disulfide bondi51 ↔ 59By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69 – 70Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

SMRiQ867D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 111Endothelin-likeAdd BLAST16

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiQ867D0.
KOiK16367.

Family and domain databases

InterProiView protein in InterPro
IPR020475. Endothelin.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
PANTHERiPTHR13874:SF9. PTHR13874:SF9. 1 hit.
PfamiView protein in Pfam
PF00322. Endothelin. 1 hit.
PRINTSiPR00365. ENDOTHELIN.
SMARTiView protein in SMART
SM00272. END. 2 hits.
PROSITEiView protein in PROSITE
PS00270. ENDOTHELIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q867D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAMPPAWCS VALALLVALH EGEGQATATP EQPVPSPRAQ GSHLRPRRCS
60 70 80 90 100
CSSWLDKECV YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPRRCECSS
110 120 130 140 150
ARDPACATFC HRRPWADAVA VPGSDSPEDT FQAGKTWTTA GELLQQLRGI
160 170
SAANIRFARR QQEAIRAPRP TPSRRRKR
Length:178
Mass (Da):19,795
Last modified:June 1, 2003 - v1
Checksum:i815C39BA0B891634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079136 mRNA. Translation: BAC54893.1.
RefSeqiNP_001075292.1. NM_001081823.2.
UniGeneiEca.12912.

Genome annotation databases

GeneIDi100033847.
KEGGiecb:100033847.

Similar proteinsi

Entry informationi

Entry nameiEDN2_HORSE
AccessioniPrimary (citable) accession number: Q867D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: December 20, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families