Reviewed,
UniProtKB/Swiss-Prot Q867B0 (ELA1_CANFA)
Last modified
June 16, 2009.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Elastase-1 EC=3.4.21.36 | ||||
| Gene names |
| ||||
| Organism | Canis familiaris (Dog) | ||||
| Taxonomic identifier | 9615 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 258 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acts upon elastin By similarity. |
| Catalytic activity | Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | Calcium Metal-binding |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 8 | 8 | By similarity | ||||||||
| Propeptide | 9 – 18 | 10 | Activation peptide | PRO_0000027673 | |||||||
| Chain | 19 – 258 | 240 | Elastase-1 | PRO_0000027674 | |||||||
Regions | |||||||||||
| Domain | 19 – 256 | 238 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 63 | 1 | Charge relay system By similarity | ||||||||
| Active site | 111 | 1 | Charge relay system By similarity | ||||||||
| Active site | 206 | 1 | Charge relay system By similarity | ||||||||
| Metal binding | 77 | 1 | Calcium By similarity | ||||||||
| Metal binding | 82 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 87 | 1 | Calcium By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 79 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 233 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 48 ↔ 64 | By similarity | |||||||||
| Disulfide bond | 145 ↔ 212 | By similarity | |||||||||
| Disulfide bond | 176 ↔ 192 | By similarity | |||||||||
| Disulfide bond | 202 ↔ 232 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Canis familiaris pancreatic elastase 1 mRNA, complete cds." Kano R., Hasegawa A. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas. |
Cross-references
Sequence databases | |
|---|---|
| AB100595 mRNA. Translation: BAC55894.1. | |
| RefSeq | NP_001003007.1. |
| UniGene | Cfa.12 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QNJ based on UniProtKB P00772. |
| SMR | Q867B0. Positions 19-258. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.153. |
Genome annotation databases | |
| Ensembl | ENSCAFG00000007774. Canis familiaris. [Contig view] |
| GeneID | 403515. |
| KEGG | cfa:403515. |
Phylogenomic databases | |
| HOVERGEN | Q867B0. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.36. 463. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ELA1_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q867B0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


