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Protein

Zinc-activated ligand-gated ion channel

Gene

ZACN

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc-activated ligand-gated ion channel.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-activated ligand-gated ion channel
Alternative name(s):
Ligand-gated ion channel zinc-activated 1
Gene namesi
Name:ZACN
Synonyms:LGICZ, LGICZ1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 233215ExtracellularSequence analysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini255 – 26511CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini287 – 29610ExtracellularSequence analysis
Transmembranei297 – 31721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini318 – 36548CytoplasmicSequence analysisAdd
BLAST
Transmembranei366 – 38621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini387 – 40923ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 409391Zinc-activated ligand-gated ion channelPRO_0000317164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 171By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ866Y9.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007487.

Structurei

3D structure databases

ProteinModelPortaliQ866Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi285 – 2884Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKFM. Eukaryota.
ENOG4111421. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000155757.
HOVERGENiHBG108756.
InParanoidiQ866Y9.
KOiK16888.
OMAiLVPCFQV.
OrthoDBiEOG091G0CPT.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q866Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLLLLLL AFLRLGTTGP LVQGRGFRSP TVAWPSFFNF NQPQGVQETI
60 70 80 90 100
QIPNNGSAPL LVDVQVFVSN VFNVDILRYT VSSMLLLRLS WVDTRLAWNA
110 120 130 140 150
SLYPQHAVTL PWDSLWTPGL TIQEALWVDW QDQSPRARVG PDGHVDLYLA
160 170 180 190 200
LTTETNCDFE LLHFPRDQSD CNLSFYALSN TVLELEFRAH AVNEIVSVKR
210 220 230 240 250
EYVVWGLETQ IPPRQLVPCF QVTLRLQNTA LKAIIALLVP GEALLLADMC
260 270 280 290 300
GGLLPLRATE RIAYKVTLLL GYLVFHSSLV QALPSSSSCN PLLIYYFTVL
310 320 330 340 350
LLLLFISTME TVLLAALQAR GHLSARSSPI PTPRGEQQDH GDLGPHPEEA
360 370 380 390 400
PGVKESRSWA EAADHIFFLV YVVGVVCSQF FFIGFWMWAT CKSDPAPGEA

IPHGGQPRL
Length:409
Mass (Da):45,529
Last modified:June 1, 2003 - v1
Checksum:iD62FFF76C317282E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512523 Genomic DNA. Translation: AAO20972.1.
RefSeqiNP_001010955.1. NM_001010955.1.
UniGeneiCfa.23486.

Genome annotation databases

EnsembliENSCAFT00000008086; ENSCAFP00000007487; ENSCAFG00000005030.
GeneIDi483326.
KEGGicfa:483326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF512523 Genomic DNA. Translation: AAO20972.1.
RefSeqiNP_001010955.1. NM_001010955.1.
UniGeneiCfa.23486.

3D structure databases

ProteinModelPortaliQ866Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007487.

Proteomic databases

PaxDbiQ866Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000008086; ENSCAFP00000007487; ENSCAFG00000005030.
GeneIDi483326.
KEGGicfa:483326.

Organism-specific databases

CTDi353174.

Phylogenomic databases

eggNOGiENOG410IKFM. Eukaryota.
ENOG4111421. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000155757.
HOVERGENiHBG108756.
InParanoidiQ866Y9.
KOiK16888.
OMAiLVPCFQV.
OrthoDBiEOG091G0CPT.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZACN_CANLF
AccessioniPrimary (citable) accession number: Q866Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The mouse and rat orthologous proteins do not exist.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.