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Q866Y3

- PGRP2_PIG

UniProt

Q866Y3 - PGRP2_PIG

Protein

N-acetylmuramoyl-L-alanine amidase

Gene

PGLYRP2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi433 – 4331ZincBy similarity
    Metal bindingi469 – 4691ZincBy similarity
    Metal bindingi544 – 5441ZincBy similarity
    Metal bindingi552 – 5521ZincBy similarity

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
    2. peptidoglycan binding Source: UniProtKB
    3. peptidoglycan receptor activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. defense response to Gram-positive bacterium Source: UniProtKB
    2. detection of bacterium Source: UniProtKB
    3. pattern recognition receptor signaling pathway Source: GOC
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Immunity

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
    Alternative name(s):
    Peptidoglycan recognition protein 2
    Peptidoglycan recognition protein long
    Short name:
    PGRP-L
    Gene namesi
    Name:PGLYRP2
    Synonyms:PGRPL
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 598567N-acetylmuramoyl-L-alanine amidasePRO_0000023922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei261 – 2611PhosphoserineBy similarity
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi441 ↔ 447By similarity
    Glycosylationi507 – 5071N-linked (GlcNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ866Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG053578.
    KOiK01446.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view]
    PANTHERiPTHR11022. PTHR11022. 1 hit.
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    SMARTiSM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: Q866Y3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPGNWKTTM VVRGILLILY GLLLQPEPGT ATLPLLMDSV IQALAELERK    50
    SPATEAGHIA SMWLLSAQGS GAHNPLPRFL LEGQSLKTAK LAPPSLSPEF 100
    QGLIEEVARH GVQDGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGHRVVNL 150
    PLDSTATFPD IGATVPDLKA TSSAHKDTSA DVNSADVGTL SPNVRDTDVD 200
    AEVTFLDVRP SSTGVQVTSP DVQVSSPDTK AKSPTTVDSL LMVTLARDLG 250
    LHFLQGAQTE SNSGLGTEGC WDQLSLPRTF TLLDPEASPL TMAFLNGALD 300
    GALLGDYLSK VPEPRPPLSH LLNQYYGAGV AGDPGLRSNF RRQNGAALTL 350
    TPNLTQQVWG TLILLQRLEP AHPQLQGMSQ EQLAQVATHA AKEFTEAFLG 400
    CPAIHPRCRW GAAPYRGSPK PLKLPLGFLY IHHTYVPARP CTDFALCAAN 450
    MRSMQRFHLD TQGWDDIGYS FVVGSDGYVY EGRGWHWVGA HTRDHNSRGF 500
    GVALIGNYTA ELPSEAALRA VRDELPHCAV RAGLLQPDYA LLGHRQLVRT 550
    DCPGDALFNM LRTWPRFNMN VKPRTARRAS GRSKRRLPLM IPLATDLQ 598
    Length:598
    Mass (Da):64,594
    Last modified:June 1, 2003 - v1
    Checksum:iFCDD237A9F105DDB
    GO
    Isoform A (identifier: Q866Y3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-346: Missing.
         347-356: ALTLTPNLTQ → MDCFCSRSQE

    Note: No experimental confirmation available.

    Show »
    Length:252
    Mass (Da):28,393
    Checksum:i365F34308D2E3560
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 346346Missing in isoform A. 1 PublicationVSP_009082Add
    BLAST
    Alternative sequencei347 – 35610ALTLTPNLTQ → MDCFCSRSQE in isoform A. 1 PublicationVSP_009083

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF541955 mRNA. Translation: AAO41115.1.
    AF541956 mRNA. Translation: AAO41116.1.
    RefSeqiNP_998903.1. NM_213738.1. [Q866Y3-1]
    UniGeneiSsc.16628.
    Ssc.82572.

    Genome annotation databases

    GeneIDi396557.
    KEGGissc:396557.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF541955 mRNA. Translation: AAO41115.1 .
    AF541956 mRNA. Translation: AAO41116.1 .
    RefSeqi NP_998903.1. NM_213738.1. [Q866Y3-1 ]
    UniGenei Ssc.16628.
    Ssc.82572.

    3D structure databases

    ProteinModelPortali Q866Y3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396557.
    KEGGi ssc:396557.

    Organism-specific databases

    CTDi 114770.

    Phylogenomic databases

    HOVERGENi HBG053578.
    KOi K01446.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view ]
    PANTHERi PTHR11022. PTHR11022. 1 hit.
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    SMARTi SM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of porcine peptidoglycan recognition proteins: gene cloning and regulation on innate immunity."
      Sang Y., Ross C.R., Blecha F.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

    Entry informationi

    Entry nameiPGRP2_PIG
    AccessioniPrimary (citable) accession number: Q866Y3
    Secondary accession number(s): Q866Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3