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Q866Y3 (PGRP2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetylmuramoyl-L-alanine amidase

EC=3.5.1.28
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name=PGRP-L
Gene names
Name:PGLYRP2
Synonyms:PGRPL
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activity

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactor

Zinc By similarity.

Subcellular location

Secreted. Membrane.

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform B (identifier: Q866Y3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A (identifier: Q866Y3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.
     347-356: ALTLTPNLTQ → MDCFCSRSQE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 598567N-acetylmuramoyl-L-alanine amidase
PRO_0000023922

Sites

Metal binding4331Zinc By similarity
Metal binding4691Zinc By similarity
Metal binding5441Zinc By similarity
Metal binding5521Zinc By similarity

Amino acid modifications

Modified residue2611Phosphoserine By similarity
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation5071N-linked (GlcNAc...) By similarity
Disulfide bond441 ↔ 447 By similarity

Natural variations

Alternative sequence1 – 346346Missing in isoform A.
VSP_009082
Alternative sequence347 – 35610ALTLTPNLTQ → MDCFCSRSQE in isoform A.
VSP_009083

Sequences

Sequence LengthMass (Da)Tools
Isoform B [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FCDD237A9F105DDB

FASTA59864,594
        10         20         30         40         50         60 
MSPGNWKTTM VVRGILLILY GLLLQPEPGT ATLPLLMDSV IQALAELERK SPATEAGHIA 

        70         80         90        100        110        120 
SMWLLSAQGS GAHNPLPRFL LEGQSLKTAK LAPPSLSPEF QGLIEEVARH GVQDGKEYGV 

       130        140        150        160        170        180 
VLAPDGSTVA VEPLLAGLEA GLQGHRVVNL PLDSTATFPD IGATVPDLKA TSSAHKDTSA 

       190        200        210        220        230        240 
DVNSADVGTL SPNVRDTDVD AEVTFLDVRP SSTGVQVTSP DVQVSSPDTK AKSPTTVDSL 

       250        260        270        280        290        300 
LMVTLARDLG LHFLQGAQTE SNSGLGTEGC WDQLSLPRTF TLLDPEASPL TMAFLNGALD 

       310        320        330        340        350        360 
GALLGDYLSK VPEPRPPLSH LLNQYYGAGV AGDPGLRSNF RRQNGAALTL TPNLTQQVWG 

       370        380        390        400        410        420 
TLILLQRLEP AHPQLQGMSQ EQLAQVATHA AKEFTEAFLG CPAIHPRCRW GAAPYRGSPK 

       430        440        450        460        470        480 
PLKLPLGFLY IHHTYVPARP CTDFALCAAN MRSMQRFHLD TQGWDDIGYS FVVGSDGYVY 

       490        500        510        520        530        540 
EGRGWHWVGA HTRDHNSRGF GVALIGNYTA ELPSEAALRA VRDELPHCAV RAGLLQPDYA 

       550        560        570        580        590 
LLGHRQLVRT DCPGDALFNM LRTWPRFNMN VKPRTARRAS GRSKRRLPLM IPLATDLQ 

« Hide

Isoform A [UniParc].

Checksum: 365F34308D2E3560
Show »

FASTA25228,393

References

[1]"Characterization of porcine peptidoglycan recognition proteins: gene cloning and regulation on innate immunity."
Sang Y., Ross C.R., Blecha F.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF541955 mRNA. Translation: AAO41115.1.
AF541956 mRNA. Translation: AAO41116.1.
RefSeqNP_998903.1. NM_213738.1.
UniGeneSsc.16628.
Ssc.82572.

3D structure databases

ProteinModelPortalQ866Y3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396557.
KEGGssc:396557.

Organism-specific databases

CTD114770.

Phylogenomic databases

HOVERGENHBG053578.
KOK01446.

Family and domain databases

Gene3D3.40.80.10. 1 hit.
InterProIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERPTHR11022. PTHR11022. 1 hit.
PfamPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMSSF55846. SSF55846. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGRP2_PIG
AccessionPrimary (citable) accession number: Q866Y3
Secondary accession number(s): Q866Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families