Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylmuramoyl-L-alanine amidase

Gene

PGLYRP2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi433ZincBy similarity1
Metal bindingi469ZincBy similarity1
Metal bindingi544ZincBy similarity1
Metal bindingi552ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name:
PGRP-L
Gene namesi
Name:PGLYRP2
Synonyms:PGRPL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002392232 – 598N-acetylmuramoyl-L-alanine amidaseAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261PhosphoserineBy similarity1
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi441 ↔ 447By similarity
Glycosylationi507N-linked (GlcNAc...)By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ866Y3.
PeptideAtlasiQ866Y3.
PRIDEiQ866Y3.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000022015.

Structurei

3D structure databases

ProteinModelPortaliQ866Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIH1. Eukaryota.
ENOG4111PAY. LUCA.
HOVERGENiHBG053578.
InParanoidiQ866Y3.
KOiK01446.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 2 hits.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q866Y3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPGNWKTTM VVRGILLILY GLLLQPEPGT ATLPLLMDSV IQALAELERK
60 70 80 90 100
SPATEAGHIA SMWLLSAQGS GAHNPLPRFL LEGQSLKTAK LAPPSLSPEF
110 120 130 140 150
QGLIEEVARH GVQDGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGHRVVNL
160 170 180 190 200
PLDSTATFPD IGATVPDLKA TSSAHKDTSA DVNSADVGTL SPNVRDTDVD
210 220 230 240 250
AEVTFLDVRP SSTGVQVTSP DVQVSSPDTK AKSPTTVDSL LMVTLARDLG
260 270 280 290 300
LHFLQGAQTE SNSGLGTEGC WDQLSLPRTF TLLDPEASPL TMAFLNGALD
310 320 330 340 350
GALLGDYLSK VPEPRPPLSH LLNQYYGAGV AGDPGLRSNF RRQNGAALTL
360 370 380 390 400
TPNLTQQVWG TLILLQRLEP AHPQLQGMSQ EQLAQVATHA AKEFTEAFLG
410 420 430 440 450
CPAIHPRCRW GAAPYRGSPK PLKLPLGFLY IHHTYVPARP CTDFALCAAN
460 470 480 490 500
MRSMQRFHLD TQGWDDIGYS FVVGSDGYVY EGRGWHWVGA HTRDHNSRGF
510 520 530 540 550
GVALIGNYTA ELPSEAALRA VRDELPHCAV RAGLLQPDYA LLGHRQLVRT
560 570 580 590
DCPGDALFNM LRTWPRFNMN VKPRTARRAS GRSKRRLPLM IPLATDLQ
Length:598
Mass (Da):64,594
Last modified:June 1, 2003 - v1
Checksum:iFCDD237A9F105DDB
GO
Isoform A (identifier: Q866Y3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.
     347-356: ALTLTPNLTQ → MDCFCSRSQE

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):28,393
Checksum:i365F34308D2E3560
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0090821 – 346Missing in isoform A. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_009083347 – 356ALTLTPNLTQ → MDCFCSRSQE in isoform A. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541955 mRNA. Translation: AAO41115.1.
AF541956 mRNA. Translation: AAO41116.1.
RefSeqiNP_998903.1. NM_213738.1. [Q866Y3-1]
UniGeneiSsc.16628.
Ssc.82572.

Genome annotation databases

GeneIDi396557.
KEGGissc:396557.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541955 mRNA. Translation: AAO41115.1.
AF541956 mRNA. Translation: AAO41116.1.
RefSeqiNP_998903.1. NM_213738.1. [Q866Y3-1]
UniGeneiSsc.16628.
Ssc.82572.

3D structure databases

ProteinModelPortaliQ866Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000022015.

Proteomic databases

PaxDbiQ866Y3.
PeptideAtlasiQ866Y3.
PRIDEiQ866Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396557.
KEGGissc:396557.

Organism-specific databases

CTDi114770.

Phylogenomic databases

eggNOGiENOG410IIH1. Eukaryota.
ENOG4111PAY. LUCA.
HOVERGENiHBG053578.
InParanoidiQ866Y3.
KOiK01446.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 2 hits.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRP2_PIG
AccessioniPrimary (citable) accession number: Q866Y3
Secondary accession number(s): Q866Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.