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Q866Y3

- PGRP2_PIG

UniProt

Q866Y3 - PGRP2_PIG

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Protein

N-acetylmuramoyl-L-alanine amidase

Gene

PGLYRP2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi433 – 4331ZincBy similarity
Metal bindingi469 – 4691ZincBy similarity
Metal bindingi544 – 5441ZincBy similarity
Metal bindingi552 – 5521ZincBy similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. peptidoglycan binding Source: UniProtKB
  3. peptidoglycan receptor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: UniProtKB
  2. detection of bacterium Source: UniProtKB
  3. pattern recognition receptor signaling pathway Source: GOC
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name:
PGRP-L
Gene namesi
Name:PGLYRP2
Synonyms:PGRPL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 598567N-acetylmuramoyl-L-alanine amidasePRO_0000023922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611PhosphoserineBy similarity
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi441 ↔ 447By similarity
Glycosylationi507 – 5071N-linked (GlcNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ866Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG053578.
InParanoidiQ866Y3.
KOiK01446.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: Q866Y3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPGNWKTTM VVRGILLILY GLLLQPEPGT ATLPLLMDSV IQALAELERK
60 70 80 90 100
SPATEAGHIA SMWLLSAQGS GAHNPLPRFL LEGQSLKTAK LAPPSLSPEF
110 120 130 140 150
QGLIEEVARH GVQDGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGHRVVNL
160 170 180 190 200
PLDSTATFPD IGATVPDLKA TSSAHKDTSA DVNSADVGTL SPNVRDTDVD
210 220 230 240 250
AEVTFLDVRP SSTGVQVTSP DVQVSSPDTK AKSPTTVDSL LMVTLARDLG
260 270 280 290 300
LHFLQGAQTE SNSGLGTEGC WDQLSLPRTF TLLDPEASPL TMAFLNGALD
310 320 330 340 350
GALLGDYLSK VPEPRPPLSH LLNQYYGAGV AGDPGLRSNF RRQNGAALTL
360 370 380 390 400
TPNLTQQVWG TLILLQRLEP AHPQLQGMSQ EQLAQVATHA AKEFTEAFLG
410 420 430 440 450
CPAIHPRCRW GAAPYRGSPK PLKLPLGFLY IHHTYVPARP CTDFALCAAN
460 470 480 490 500
MRSMQRFHLD TQGWDDIGYS FVVGSDGYVY EGRGWHWVGA HTRDHNSRGF
510 520 530 540 550
GVALIGNYTA ELPSEAALRA VRDELPHCAV RAGLLQPDYA LLGHRQLVRT
560 570 580 590
DCPGDALFNM LRTWPRFNMN VKPRTARRAS GRSKRRLPLM IPLATDLQ
Length:598
Mass (Da):64,594
Last modified:June 1, 2003 - v1
Checksum:iFCDD237A9F105DDB
GO
Isoform A (identifier: Q866Y3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.
     347-356: ALTLTPNLTQ → MDCFCSRSQE

Note: No experimental confirmation available.

Show »
Length:252
Mass (Da):28,393
Checksum:i365F34308D2E3560
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 346346Missing in isoform A. 1 PublicationVSP_009082Add
BLAST
Alternative sequencei347 – 35610ALTLTPNLTQ → MDCFCSRSQE in isoform A. 1 PublicationVSP_009083

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541955 mRNA. Translation: AAO41115.1.
AF541956 mRNA. Translation: AAO41116.1.
RefSeqiNP_998903.1. NM_213738.1. [Q866Y3-1]
UniGeneiSsc.16628.
Ssc.82572.

Genome annotation databases

GeneIDi396557.
KEGGissc:396557.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541955 mRNA. Translation: AAO41115.1 .
AF541956 mRNA. Translation: AAO41116.1 .
RefSeqi NP_998903.1. NM_213738.1. [Q866Y3-1 ]
UniGenei Ssc.16628.
Ssc.82572.

3D structure databases

ProteinModelPortali Q866Y3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396557.
KEGGi ssc:396557.

Organism-specific databases

CTDi 114770.

Phylogenomic databases

HOVERGENi HBG053578.
InParanoidi Q866Y3.
KOi K01446.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of porcine peptidoglycan recognition proteins: gene cloning and regulation on innate immunity."
    Sang Y., Ross C.R., Blecha F.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiPGRP2_PIG
AccessioniPrimary (citable) accession number: Q866Y3
Secondary accession number(s): Q866Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3