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Q866Y3

- PGRP2_PIG

UniProt

Q866Y3 - PGRP2_PIG

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Protein
N-acetylmuramoyl-L-alanine amidase
Gene
PGLYRP2, PGRPL
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi433 – 4331Zinc By similarity
Metal bindingi469 – 4691Zinc By similarity
Metal bindingi544 – 5441Zinc By similarity
Metal bindingi552 – 5521Zinc By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. peptidoglycan binding Source: UniProtKB
  3. peptidoglycan receptor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: UniProtKB
  2. detection of bacterium Source: UniProtKB
  3. pattern recognition receptor signaling pathway Source: GOC
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name:
PGRP-L
Gene namesi
Name:PGLYRP2
Synonyms:PGRPL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed prediction
Add
BLAST
Chaini32 – 598567N-acetylmuramoyl-L-alanine amidase
PRO_0000023922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611Phosphoserine By similarity
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi441 ↔ 447 By similarity
Glycosylationi507 – 5071N-linked (GlcNAc...) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ866Y3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG053578.
KOiK01446.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: Q866Y3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPGNWKTTM VVRGILLILY GLLLQPEPGT ATLPLLMDSV IQALAELERK    50
SPATEAGHIA SMWLLSAQGS GAHNPLPRFL LEGQSLKTAK LAPPSLSPEF 100
QGLIEEVARH GVQDGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGHRVVNL 150
PLDSTATFPD IGATVPDLKA TSSAHKDTSA DVNSADVGTL SPNVRDTDVD 200
AEVTFLDVRP SSTGVQVTSP DVQVSSPDTK AKSPTTVDSL LMVTLARDLG 250
LHFLQGAQTE SNSGLGTEGC WDQLSLPRTF TLLDPEASPL TMAFLNGALD 300
GALLGDYLSK VPEPRPPLSH LLNQYYGAGV AGDPGLRSNF RRQNGAALTL 350
TPNLTQQVWG TLILLQRLEP AHPQLQGMSQ EQLAQVATHA AKEFTEAFLG 400
CPAIHPRCRW GAAPYRGSPK PLKLPLGFLY IHHTYVPARP CTDFALCAAN 450
MRSMQRFHLD TQGWDDIGYS FVVGSDGYVY EGRGWHWVGA HTRDHNSRGF 500
GVALIGNYTA ELPSEAALRA VRDELPHCAV RAGLLQPDYA LLGHRQLVRT 550
DCPGDALFNM LRTWPRFNMN VKPRTARRAS GRSKRRLPLM IPLATDLQ 598
Length:598
Mass (Da):64,594
Last modified:June 1, 2003 - v1
Checksum:iFCDD237A9F105DDB
GO
Isoform A (identifier: Q866Y3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.
     347-356: ALTLTPNLTQ → MDCFCSRSQE

Note: No experimental confirmation available.

Show »
Length:252
Mass (Da):28,393
Checksum:i365F34308D2E3560
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 346346Missing in isoform A.
VSP_009082Add
BLAST
Alternative sequencei347 – 35610ALTLTPNLTQ → MDCFCSRSQE in isoform A.
VSP_009083

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF541955 mRNA. Translation: AAO41115.1.
AF541956 mRNA. Translation: AAO41116.1.
RefSeqiNP_998903.1. NM_213738.1. [Q866Y3-1]
UniGeneiSsc.16628.
Ssc.82572.

Genome annotation databases

GeneIDi396557.
KEGGissc:396557.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF541955 mRNA. Translation: AAO41115.1 .
AF541956 mRNA. Translation: AAO41116.1 .
RefSeqi NP_998903.1. NM_213738.1. [Q866Y3-1 ]
UniGenei Ssc.16628.
Ssc.82572.

3D structure databases

ProteinModelPortali Q866Y3.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396557.
KEGGi ssc:396557.

Organism-specific databases

CTDi 114770.

Phylogenomic databases

HOVERGENi HBG053578.
KOi K01446.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of porcine peptidoglycan recognition proteins: gene cloning and regulation on innate immunity."
    Sang Y., Ross C.R., Blecha F.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiPGRP2_PIG
AccessioniPrimary (citable) accession number: Q866Y3
Secondary accession number(s): Q866Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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