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Protein
Submitted name:

Aquaporin 4A

Gene

AQP4A

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin 4AImported
Submitted name:
Aquaporin-4 M1 isoformImported
Gene namesi
Name:AQP4AImported
Synonyms:AQP4Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 23

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 59HelicalSequence analysisAdd BLAST18
Transmembranei71 – 94HelicalSequence analysisAdd BLAST24
Transmembranei115 – 136HelicalSequence analysisAdd BLAST22
Transmembranei156 – 177HelicalSequence analysisAdd BLAST22
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Transmembranei231 – 253HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
KOiK09866.
OMAiCRRESIM.
OrthoDBiEOG091G166T.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q866S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRPAARRW GKCGPLCTRE SIMVAFKGVW TQTFWKAVTA EFLAMLIFVL
60 70 80 90 100
LSLGSTINWG GAEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV
110 120 130 140 150
TVAMVCTRRI SIAKAVFYIA AQCLGAIIGA GILYLVTPPS VVGGLGVTTV
160 170 180 190 200
HRNLSAGHGL LVELIITFQL VFTIFASCDS KRTDVTGSIA LAIGISVAIG
210 220 230 240 250
HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG AVLAGGLYEY
260 270 280 290 300
VFCPDVELKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH
310 320
VIDIDRGEEK KGKDPSGEVL SSV
Length:323
Mass (Da):34,755
Last modified:June 1, 2003 - v1
Checksum:iD95929E21374948D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01066490 Genomic DNA. No translation available.
AY177612 mRNA. Translation: AAO21366.1.
AY304480 mRNA. Translation: AAQ74771.1.
RefSeqiNP_001009279.1. NM_001009279.1.
UniGeneiOar.1017.

Genome annotation databases

EnsembliENSOART00000007588; ENSOARP00000007476; ENSOARG00000006982.
GeneIDi443268.
KEGGioas:443268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01066490 Genomic DNA. No translation available.
AY177612 mRNA. Translation: AAO21366.1.
AY304480 mRNA. Translation: AAQ74771.1.
RefSeqiNP_001009279.1. NM_001009279.1.
UniGeneiOar.1017.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000007588; ENSOARP00000007476; ENSOARG00000006982.
GeneIDi443268.
KEGGioas:443268.

Organism-specific databases

CTDi361.

Phylogenomic databases

GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
KOiK09866.
OMAiCRRESIM.
OrthoDBiEOG091G166T.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ866S4_SHEEP
AccessioniPrimary (citable) accession number: Q866S4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 10, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.