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Protein

Adenylate cyclase type 10

Gene

ADCY10

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity).By similarity

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity

Enzyme regulationi

Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate. Calcium mildly increases the enzyme activity, also in the presence of magnesium ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Magnesium 1PROSITE-ProRule annotation1
Metal bindingi47Magnesium 2PROSITE-ProRule annotation1
Metal bindingi48Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei95BicarbonateBy similarity1
Metal bindingi99Magnesium 1PROSITE-ProRule annotation1
Metal bindingi99Magnesium 2PROSITE-ProRule annotation1
Binding sitei99ATPBy similarity1
Binding sitei144ATPBy similarity1
Binding sitei167Bicarbonate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei176BicarbonateBy similarity1
Binding sitei337Bicarbonate; via amide nitrogenBy similarity1
Binding sitei406ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 52ATPBy similarity6
Nucleotide bindingi412 – 416ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 10 (EC:4.6.1.1)
Alternative name(s):
Germ cell soluble adenylyl cyclase
Short name:
sAC
Testicular soluble adenylyl cyclase
Gene namesi
Name:ADCY10
Synonyms:SAC
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmperinuclear region By similarity
  • Nucleus By similarity
  • Cell projectioncilium By similarity
  • Cytoplasm By similarity

  • Note: Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171031 – 1610Adenylate cyclase type 10Add BLAST1610

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001957.

Structurei

3D structure databases

ProteinModelPortaliQ866F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 179Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST138
Domaini293 – 418Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi909 – 912Poly-Glu4

Domaini

The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments containing the first 470 amino acid residues are fully active.By similarity

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEPA. Eukaryota.
ENOG410ZFMC. LUCA.
HOGENOMiHOG000060149.
HOVERGENiHBG103835.
InParanoidiQ866F4.
KOiK11265.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
3.30.70.1230. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR016577. Adenylate_cylcase_typ10.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 2 hits.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q866F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTRKEELQD RAIVRIAAHL PDLIVYGDFS PQRPSVDYFD GVLMFVDISG
60 70 80 90 100
FTAMTEKFST AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA
110 120 130 140 150
LLALWKVERK QLKNIITVVI KCSLEIHGLF GTQESEEGLD IRVKIGLAAG
160 170 180 190 200
HISMLVFGDE TRNHFLVIGQ AVDDVRLAQN MARMNDVILS PNCWQLCDRS
210 220 230 240 250
MIEIERIPDQ RAVKVNFLKP PPSFNFDEFF NKCMTFMDYY PSGDHKNLLR
260 270 280 290 300
LACMLESDPD LELSLQKYVM ESILKQIDDK QLRGYLSELR PVTIVFVNLM
310 320 330 340 350
FQDQNKAEVI GSAIQDACVH ISSVLKVFRG QINKVFMFDK GCSFLCVFGF
360 370 380 390 400
PGEKAPDEVT HALESAVDIF DFCSQVHKIH TVSIGVASGI VFCGIVGHTV
410 420 430 440 450
RHEYTVIGQK VNIAARMMMY YPGIVTCDSV TYNGSNLPPY FFKELPKKLM
460 470 480 490 500
KGVGDSGPVY QCLGLNEKVM FGMAYLTCNR NEGYPLLGRD KEIKYFMCTM
510 520 530 540 550
KEFLMSNCSR VLMYEGLSGF GKSRILMEIE YLAQGENHRT IAIALTKVSF
560 570 580 590 600
HQNFYTIQIL MANVLGLDTC KHYKERQTNL QNKVKTLLDE KFHCLLNDIF
610 620 630 640 650
HVQFPISREI SKMSTFRKQK QLEALFMKIL EQTVKEERII FIIDEAQFVD
660 670 680 690 700
YASWIFMEKL IRTVPIFIIM SLSPFTEIPC AAASAIMKNR NTTYVTLGAV
710 720 730 740 750
QPNDIRNKVC LDLNVSSIPK ELDLYLVEGS CGIPFYCEEL VKNLDHHRVL
760 770 780 790 800
VFQQMETEEK TKVTWNNLFK NFIKPTEEFK MSGLGNEEGT EEICKLASGV
810 820 830 840 850
RLKNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF TTELLFEILP
860 870 880 890 900
CWNMKMMIKA LATLVESNIF DCFRDGKDLR LALKQNAASF EVHNRSLSLQ
910 920 930 940 950
PTEGIAHGEE EELRELESEV IECHIIRFCK PMMQKTAYEL WLKDQKKAMH
960 970 980 990 1000
LKCARFLEEN AHRCDHCRSG DFIPYHHFTV DIRLNTLDMD TIKKMATSHG
1010 1020 1030 1040 1050
FETEEEIKIS RAGIPKNSEL FSENLSPEEI GERILGFFDV ILTKMKTSKE
1060 1070 1080 1090 1100
DIIPLESCQC EEILEIVILP LAQHFLALGE NNKALYYFLE ITSAYLTLGD
1110 1120 1130 1140 1150
NYMAYMYLNE GERLLKTLKK EKSWSQTFES ATFYSLKGQV CFNMGQMVLA
1160 1170 1180 1190 1200
KKMLRKALKL LNRIFPYNLI SLFLHTHMEK NRHFHYVTQQ AQESSPPGKK
1210 1220 1230 1240 1250
RLAHLYQQTA CFSLLWQIYS LNYFFHHKYY GHLAAMMELN TALETQNDFQ
1260 1270 1280 1290 1300
IIKAYLDYAM YHHLAGYQGV WFKYEVKAME QIFNLPLKGE GIEIVAYVAG
1310 1320 1330 1340 1350
KLSYIKLMMG YLDLAIELGA RAHKMWALLQ NPNQHYVVLC RLSKSLFLKN
1360 1370 1380 1390 1400
RYKHLIQMLR RLWDLSVAEG HIISKAFFYL VCLDIMLYSG FVYRTFEECL
1410 1420 1430 1440 1450
EFIIQNEDNR ILKFQSGLLL GLYSSIAIWY GRLQEWDNFY VFSNRAKTLV
1460 1470 1480 1490 1500
SRRTPTILYY DGVSRYMEGQ VLQLQKQIEE QSETAQDSGV ELLKSLESLV
1510 1520 1530 1540 1550
AQNTTGPVFY PRLYHLMAYI CILMGDGQNC DLFLNTALKL SEIQGNVLEK
1560 1570 1580 1590 1600
CWLNMSKEWW YSNCTLTEDQ WLHTILSLPA WEKIVSGKVN IHDVQKNKFL
1610
MRVNILDNPF
Length:1,610
Mass (Da):185,520
Last modified:June 1, 2003 - v1
Checksum:iB86C2B4E8A4E3207
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212921 mRNA. Translation: AAO38673.1.
RefSeqiNP_001075622.1. NM_001082153.1.
UniGeneiOcu.3193.

Genome annotation databases

GeneIDi100008902.
KEGGiocu:100008902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212921 mRNA. Translation: AAO38673.1.
RefSeqiNP_001075622.1. NM_001082153.1.
UniGeneiOcu.3193.

3D structure databases

ProteinModelPortaliQ866F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008902.
KEGGiocu:100008902.

Organism-specific databases

CTDi55811.

Phylogenomic databases

eggNOGiENOG410IEPA. Eukaryota.
ENOG410ZFMC. LUCA.
HOGENOMiHOG000060149.
HOVERGENiHBG103835.
InParanoidiQ866F4.
KOiK11265.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
3.30.70.1230. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR016577. Adenylate_cylcase_typ10.
IPR029787. Nucleotide_cyclase.
IPR027417. P-loop_NTPase.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 2 hits.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADCYA_RABIT
AccessioniPrimary (citable) accession number: Q866F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.