Reviewed, UniProtKB/Swiss-Prot Q866F1 (FUT1_SAISC)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
    Alpha(1,2)FT 1
    Fucosyltransferase 1

Gene names

Name:

FUT1

Organism

Saimiri sciureus (Common squirrel monkey)

Taxonomic identifier

9521 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149105
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Signal-anchor for type II membrane protein Potential
	Topological domain	26 – 366	341	Lumenal Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q866F1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1D0735248BFCC3A3	FASTA	366	41,322
	10 20 30 40 50 60 MWPRSHRHLC LAFLLVCVLS AISFLIHFHQ DSIRHGLGLS VLCPDRRLVT PPVAIFCLPG 70 80 90 100 110 120 TPMSPNTSSP CPQHPASLSG TWTIYPDGRF GNQMGQYATL LALAQLNGRR AFILPAMHAA 130 140 150 160 170 180 LAPVFRITLP VLAPEVDSRT PWQELRLHDW MSEEYADLGD PFLKLSGFPC SWTFFHHLRE 190 200 210 220 230 240 QIRSEFTLHD HLREEAQSVL RRLRLGRSGA RPRTFVGVHV RRGDYLQVMP QRWKGVVANS 250 260 270 280 290 300 AYLREAMDWF RARHEAPVFV VTSNGMEWCR ENIDASKGDV MFAGDGQEAS PWKDFALLAQ 310 320 330 340 350 360 CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW VGINADLSPL WPLAEP

References

[1]	"Molecular evolution of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini): evidence of divergent evolution and purifying selection." Borges B.N., Harada M.L. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY219617 Genomic DNA. Translation: AAO43059.1.
3D structure databases
SMR	Q866F1. Positions 86-321.
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Phylogenomic databases
HOVERGEN	Q866F1.
Enzyme and pathway databases
BRENDA	2.4.1.69. 189317.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_SAISC

Accession

Primary (citable) accession number: Q866F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)