Reviewed, UniProtKB/Swiss-Prot Q866D6 (FUT1_LEOCY)

Names and origin

Protein names

Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    EC=2.4.1.69
Alternative name(s):
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
    Alpha(1,2)FT 1
    Fucosyltransferase 1

Gene names

Name:

FUT1

Organism

Leontopithecus chrysomelas (Golden-headed lion tamarin)

Taxonomic identifier

57374 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Leontopithecus

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149097
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Signal-anchor for type II membrane protein Potential
	Topological domain	26 – 365	340	Lumenal Potential
Amino acid modifications
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q866D6-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B1E5DE6504D8112F	FASTA	365	41,198
	10 20 30 40 50 60 MWPLSHRHLC LAFLLVCVLS AISFFLHLYQ DSIRHGLGLS ILCPDRLVTA PVAIFCLPDT 70 80 90 100 110 120 PVSPNTSSPC PQHPASLSGT WTIYPDGRFG NQMGQYATLL ALAQLNGRRA FILPAMHATL 130 140 150 160 170 180 APVFRITLPV LAPEVDSSTP WRELQLHDWM SEEYADLGDP FLKLSGFPCS WTFFHHLREQ 190 200 210 220 230 240 ILSEFTLHDH LREEAQSVLR RLRLGRSGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGNSA 250 260 270 280 290 300 YLREAMDWFR ARHEAPVFVV TSNGMEWCRE NIDASKGDVM FAGDGREALP WKDFALLTQC 310 320 330 340 350 360 NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPLW TLAEP

References

[1]	"Molecular evolution of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini): evidence of divergent evolution and purifying selection." Borges B.N., Harada M.L. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY219632 Genomic DNA. Translation: AAO43074.1.
3D structure databases
SMR	Q866D6. Positions 85-320.
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Phylogenomic databases
HOVERGEN	Q866D6.
Enzyme and pathway databases
BRENDA	2.4.1.69. 301658.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_LEOCY

Accession

Primary (citable) accession number: Q866D6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)