Q866C9 (FUT1_LAGLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1
EC=2.4.1.69

Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1

Gene names

Name:

FUT1

Organism

Lagothrix lagotricha (Common woolly monkey)

Taxonomic identifier

9519 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Atelidae › Atelinae › Lagothrix

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 11 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	galactoside 2-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Galactoside 2-alpha-L-fucosyltransferase 1		PRO_0000149096
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	26 – 366	341	Lumenal Potential
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q866C9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 28A45CC9816C944D	FASTA	366	41,308
	10 20 30 40 50 60 MWPLSHRHLC LAFLLVCVLS AISFFLHIHQ DSFPHGLGLS VLCPDRRLVT HPVAIFCLPG 70 80 90 100 110 120 TPMSPNTSSP CPQHAASLSG TWTIYPDGRF GNQMGQYATL LALAQLNGRQ AFILPAMHAA 130 140 150 160 170 180 LAPVFRITLP VLAPEVDSRT PWRELRLHDW MSEEYADLGD PFLKLSGFPC SWTFFHHLRE 190 200 210 220 230 240 QIRSEFTLHD HLREEAQSVL RRLHLGRSGD RPRTFVGVHV RRGDYLQVMP QRWRGVVGNS 250 260 270 280 290 300 AYLREAMDWF RARHEAPVFV VTSNGMEWCR ENIDASKGDV VFAGDGQEAS PWKDFALLTQ 310 320 330 340 350 360 CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW VGINADLSPL WTLAEP

References

[1]	"Molecular evolution of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini): evidence of divergent evolution and purifying selection." Borges B.N., Harada M.L. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY219639 Genomic DNA. Translation: AAO43081.1.
3D structure databases
ProteinModelPortal	Q866C9.
ModBase	Search...
Protein family/group databases
CAZy	GT11. Glycosyltransferase Family 11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004338.
Family and domain databases
InterPro	IPR002516. Glyco_trans_11. [Graphical view]
PANTHER	PTHR11927. Glyco_trans_11. 1 hit.
Pfam	PF01531. Glyco_transf_11. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT1_LAGLA

Accession

Primary (citable) accession number: Q866C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	June 1, 2003
Last modified:	May 31, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program