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Q865Y1

- IL2_PAPAN

UniProt

Q865Y1 - IL2_PAPAN

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Protein

Interleukin-2

Gene

IL2

Organism
Papio anubis (Olive baboon)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity).By similarity

GO - Biological processi

  1. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
Synonyms:IL-2
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 154134Interleukin-2PRO_0000015496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)By similarity
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ865Y1.
SMRiQ865Y1. Positions 21-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007496.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q865Y1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL
110 120 130 140 150
RDTKDLISNI NVIVLELKGS ETTLMCEYAD ETATIVEFLN RWITFCQSII

STLT
Length:154
Mass (Da):17,713
Last modified:June 1, 2003 - v1
Checksum:i47F486BDF204AD6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234220 mRNA. Translation: AAO85333.1.
RefSeqiNP_001106124.1. NM_001112654.1.
UniGeneiPan.11105.

Genome annotation databases

GeneIDi100126754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234220 mRNA. Translation: AAO85333.1 .
RefSeqi NP_001106124.1. NM_001112654.1.
UniGenei Pan.11105.

3D structure databases

ProteinModelPortali Q865Y1.
SMRi Q865Y1. Positions 21-154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100126754.

Organism-specific databases

CTDi 3558.

Phylogenomic databases

HOVERGENi HBG007496.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nonhuman primate cytokines."
    Villinger F.J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2_PAPAN
AccessioniPrimary (citable) accession number: Q865Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3