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Q865Y1 (IL2_PAPAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-2

Short name=IL-2
Alternative name(s):
T-cell growth factor
Short name=TCGF
Gene names
Name:IL2
Synonyms:IL-2
OrganismPapio anubis (Olive baboon)
Taxonomic identifier9555 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-2 family.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processimmune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 154134Interleukin-2
PRO_0000015496

Amino acid modifications

Glycosylation231O-linked (GalNAc...) By similarity
Disulfide bond78 ↔ 126 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q865Y1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 47F486BDF204AD6E

FASTA15417,713
        10         20         30         40         50         60 
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 

        70         80         90        100        110        120 
TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL RDTKDLISNI NVIVLELKGS 

       130        140        150 
ETTLMCEYAD ETATIVEFLN RWITFCQSII STLT 

« Hide

References

[1]"Nonhuman primate cytokines."
Villinger F.J.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY234220 mRNA. Translation: AAO85333.1.
RefSeqNP_001106124.1. NM_001112654.1.
UniGenePan.11105.

3D structure databases

ProteinModelPortalQ865Y1.
SMRQ865Y1. Positions 21-154.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100126754.

Organism-specific databases

CTD3558.

Phylogenomic databases

HOVERGENHBG007496.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERPTHR11443. PTHR11443. 1 hit.
PfamPF00715. IL2. 1 hit.
[Graphical view]
PRINTSPR00265. INTERLEUKIN2.
ProDomPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIL2_PAPAN
AccessionPrimary (citable) accession number: Q865Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families