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Q865Y1

- IL2_PAPAN

UniProt

Q865Y1 - IL2_PAPAN

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Protein

Interleukin-2

Gene
IL2, IL-2
Organism
Papio anubis (Olive baboon)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells By similarity.

GO - Biological processi

  1. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
Synonyms:IL-2
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarityAdd
BLAST
Chaini21 – 154134Interleukin-2PRO_0000015496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...) By similarity
Disulfide bondi78 ↔ 126 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ865Y1.
SMRiQ865Y1. Positions 21-154.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007496.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q865Y1-1 [UniParc]FASTAAdd to Basket

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MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN    50
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL 100
RDTKDLISNI NVIVLELKGS ETTLMCEYAD ETATIVEFLN RWITFCQSII 150
STLT 154
Length:154
Mass (Da):17,713
Last modified:June 1, 2003 - v1
Checksum:i47F486BDF204AD6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY234220 mRNA. Translation: AAO85333.1.
RefSeqiNP_001106124.1. NM_001112654.1.
UniGeneiPan.11105.

Genome annotation databases

GeneIDi100126754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY234220 mRNA. Translation: AAO85333.1 .
RefSeqi NP_001106124.1. NM_001112654.1.
UniGenei Pan.11105.

3D structure databases

ProteinModelPortali Q865Y1.
SMRi Q865Y1. Positions 21-154.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100126754.

Organism-specific databases

CTDi 3558.

Phylogenomic databases

HOVERGENi HBG007496.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nonhuman primate cytokines."
    Villinger F.J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL2_PAPAN
AccessioniPrimary (citable) accession number: Q865Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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