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Protein

Interleukin-2

Gene

IL2

Organism
Papio anubis (Olive baboon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
Synonyms:IL-2
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001549621 – 154Interleukin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ865Y1.
SMRiQ865Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007496.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q865Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL
110 120 130 140 150
RDTKDLISNI NVIVLELKGS ETTLMCEYAD ETATIVEFLN RWITFCQSII

STLT
Length:154
Mass (Da):17,713
Last modified:June 1, 2003 - v1
Checksum:i47F486BDF204AD6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY234220 mRNA. Translation: AAO85333.1.
RefSeqiNP_001106124.1. NM_001112654.1.
UniGeneiPan.11105.

Genome annotation databases

GeneIDi100126754.

Similar proteinsi

Entry informationi

Entry nameiIL2_PAPAN
AccessioniPrimary (citable) accession number: Q865Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families