Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q865Y1

- IL2_PAPAN

UniProt

Q865Y1 - IL2_PAPAN

Protein

Interleukin-2

Gene

IL2

Organism
Papio anubis (Olive baboon)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells By similarity.By similarity

    GO - Biological processi

    1. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-2
    Short name:
    IL-2
    Alternative name(s):
    T-cell growth factor
    Short name:
    TCGF
    Gene namesi
    Name:IL2
    Synonyms:IL-2
    OrganismiPapio anubis (Olive baboon)
    Taxonomic identifieri9555 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 154134Interleukin-2PRO_0000015496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231O-linked (GalNAc...)By similarity
    Disulfide bondi78 ↔ 126By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ865Y1.
    SMRiQ865Y1. Positions 21-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG007496.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view]
    PANTHERiPTHR11443. PTHR11443. 1 hit.
    PfamiPF00715. IL2. 1 hit.
    [Graphical view]
    PRINTSiPR00265. INTERLEUKIN2.
    ProDomiPD003649. Interleukin-2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00189. IL2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q865Y1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN    50
    YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL 100
    RDTKDLISNI NVIVLELKGS ETTLMCEYAD ETATIVEFLN RWITFCQSII 150
    STLT 154
    Length:154
    Mass (Da):17,713
    Last modified:June 1, 2003 - v1
    Checksum:i47F486BDF204AD6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY234220 mRNA. Translation: AAO85333.1.
    RefSeqiNP_001106124.1. NM_001112654.1.
    UniGeneiPan.11105.

    Genome annotation databases

    GeneIDi100126754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY234220 mRNA. Translation: AAO85333.1 .
    RefSeqi NP_001106124.1. NM_001112654.1.
    UniGenei Pan.11105.

    3D structure databases

    ProteinModelPortali Q865Y1.
    SMRi Q865Y1. Positions 21-154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100126754.

    Organism-specific databases

    CTDi 3558.

    Phylogenomic databases

    HOVERGENi HBG007496.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view ]
    PANTHERi PTHR11443. PTHR11443. 1 hit.
    Pfami PF00715. IL2. 1 hit.
    [Graphical view ]
    PRINTSi PR00265. INTERLEUKIN2.
    ProDomi PD003649. Interleukin-2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00189. IL2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nonhuman primate cytokines."
      Villinger F.J.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL2_PAPAN
    AccessioniPrimary (citable) accession number: Q865Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3