Q865Y1 (IL2_PAPAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-2
Short name=IL-2

Alternative name(s):
T-cell growth factor
Short name=TCGF

Gene names

Name:	IL2
Synonyms:	IL-2

Organism

Papio anubis (Olive baboon)

Taxonomic identifier

9555 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-2 family.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 154	134	Interleukin-2		PRO_0000015496
Amino acid modifications
	Glycosylation	23	1	O-linked (GalNAc...) By similarity
	Disulfide bond	78 ↔ 126		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q865Y1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 47F486BDF204AD6E	FASTA	154	17,713
	10 20 30 40 50 60 MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 70 80 90 100 110 120 TFKFYMPKKA TELKHLQCLE EELRPLEEVL NLAQSKNFHL RDTKDLISNI NVIVLELKGS 130 140 150 ETTLMCEYAD ETATIVEFLN RWITFCQSII STLT

References

[1]	"Nonhuman primate cytokines." Villinger F.J. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY234220 mRNA. Translation: AAO85333.1.
RefSeq	NP_001106124.1. NM_001112654.1.
UniGene	Pan.11105.
3D structure databases
ProteinModelPortal	Q865Y1.
SMR	Q865Y1. Positions 21-154.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100126754.
Organism-specific databases
CTD	3558.
Phylogenomic databases
HOVERGEN	HBG007496.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000779. Interleukin-2. [Graphical view]
PANTHER	PTHR11443. PTHR11443. 1 hit.
Pfam	PF00715. IL2. 1 hit. [Graphical view]
PRINTS	PR00265. INTERLEUKIN2.
ProDom	PD003649. Interleukin-2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00189. IL2. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00424. INTERLEUKIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IL2_PAPAN

Accession

Primary (citable) accession number: Q865Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	June 1, 2003
Last modified:	March 6, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program