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Q865W3

- Q865W3_CANFA

UniProt

Q865W3 - Q865W3_CANFA

Protein

Sodium channel protein

Gene

scn5A

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:scn5AImported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliQ865W3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    InParanoidiQ865W3.
    KOiK04838.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q865W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE     50
    APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK 100
    TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ 150
    HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 200
    IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL 250
    ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV 300
    WESLDHYLSD SGNYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH 350
    GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 400
    SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 450
    RGVDTVSRSS LEMSPLAPVT THERRSKRRK RMSSGTEECG DDRFPKSDSE 500
    DGPRAMNRLS STHGLSRTSV KPRSSRGSIF TFRRRDLGSE TDFADDENST 550
    AGDSESHRTS LLVPWPLRQP SAQGQLSPGT SAPALNGKRN STVDCNGVVS 600
    LLGAGDLEAT SPGSHLLRPV ILDRPPDTTT PSEEPGRPQM LTPQAPCVDG 650
    FEEPGERQRA LSAVSVLTSA LEELEESHRK CPPCWNRFAQ RYLIWECCPL 700
    WMSIKQRVKF MVMDPFADLT ITMCIVLNTL FMALEHYNMT AEFEEMLQVG 750
    NLVFTGIFTA EMTFKIIALD PYYYFQQGWN IFDSIIVILS LMELGLSRMG 800
    NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI 850
    FAVVGMQLFG KNYSEQRHRI SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 900
    ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP 950
    DDDGEMNNLQ LALARIQRGL RFLKRTTWDF CCGLLQRPPK PTALAAHGQL 1000
    PGCMATSSSP PPPESQKVPP ARKETRFEED KQPGQGTPGD TEPVCVPIAM 1050
    AESDTDDQEE DEENSLGTEE ESSKQQESQP VSGSPEAVPE RGAWSQVSET 1100
    ASSEASVAQA DWRQQRKVEP PAPGCSEAPE DSYSEGSTAD MTNTADLLEQ 1150
    IPDLGEDVKD PEDCFTEGCV RRCPCCAVDT TQAPGKVWWR LRKTCYRIVE 1200
    HSWFETFIIF MILLSSGALA FEDIYLEERK TIKVLLEYAD KMFTYIFVLE 1250
    MLLKWVAYGF KKYFTNAWCW LDFLIVDVSL ISLVANTLGF AEMGPIKSLR 1300
    TLRALRPLRA LSRFEGMRVV VNALVGAIPS IMNVLLVCLI FWLIFSIMGV 1350
    NMFAGKFGRC INQTEGDLPL NYTVVNNKSD CESFNVTGEL YWTKVKVNFD 1400
    NVGAGYLALL QVATFKGWMD IMYAAVDSRG FEEQPQWEYN LYMYIYFVIF 1450
    IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS 1500
    KKPQKPIPRP LNKYQGFLFD IVTKQAFDVT IMFLICLNMV TMMVETDDQS 1550
    PEKVNILAKI NLLFVAIFTG ECIIKMAALR HYYFTNSWNI FDFVVVILSI 1600
    VGTVLSDIIQ KYFFSPTLFR VIRLARIGRI LRLIRGAKGI RTLLFALMMS 1650
    LPALFNIGLL LFLVMFIYSI FGMANFAYVK WEAGIDDMFN FQTFANSMLC 1700
    LFQITTSAGW DGLLSPILNT GPPYCDPNLP NSNGSRGNCG SPAVGILFFT 1750
    TYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFDM FYEIWEKFDP 1800
    EATQFIEYSA LSDFADALSE PLRIAKPNQI SLINMDLPMV SGDRIHCMDI 1850
    LFAFTKRVLG ESGEMDALKI QMEEKFMAAN PSKISYEPIT TTLRRKHEEV 1900
    SATVIQRAFR RHLLQRSVKH ASFLYRQQAG GARSGERAPE REGLIAYTMA 1950
    ENFSRRLGPP SSSSISSTSS PPSYDSVTRA TSDNPQVRAS DYSRSEDLAD 2000
    LPPSPDRDRE SIV 2013
    Length:2,013
    Mass (Da):226,773
    Last modified:June 1, 2003 - v1
    Checksum:i7EC85279FC6CD0C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ555547 mRNA. Translation: CAD88248.1.
    RefSeqiNP_001002994.1. NM_001002994.1.
    XP_005634204.1. XM_005634147.1.
    UniGeneiCfa.209.

    Genome annotation databases

    GeneIDi403497.
    KEGGicfa:403497.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ555547 mRNA. Translation: CAD88248.1 .
    RefSeqi NP_001002994.1. NM_001002994.1.
    XP_005634204.1. XM_005634147.1.
    UniGenei Cfa.209.

    3D structure databases

    ProteinModelPortali Q865W3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403497.
    KEGGi cfa:403497.

    Organism-specific databases

    CTDi 6331.

    Phylogenomic databases

    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    InParanoidi Q865W3.
    KOi K04838.

    Miscellaneous databases

    NextBioi 20817011.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR008053. Na_channel_a5su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    PR01666. NACHANNEL5.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles."
      Haufe V., Cordeiro J.M., Zimmer T., Wu Y.S., Schiccitano S., Benndorf K., Dumaine R.
      Cardiovasc. Res. 65:117-127(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeartImported.

    Entry informationi

    Entry nameiQ865W3_CANFA
    AccessioniPrimary (citable) accession number: Q865W3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    External Data

    Dasty 3