Q865W3 (Q865W3_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Voltage-gated sodium channel alpha subunit EMBL CAD88248.1

Gene names

Name:

scn5A EMBL CAD88248.1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) EMBL CAD88248.1

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	2013 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.
Sequence similarities	Belongs to the sodium channel family. RuleBase RU003809

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Sodium
Molecular function	Ion channel Sodium channel RuleBase RU003809 Voltage-gated channel RuleBase RU003809
Gene Ontology (GO)
Biological_process	sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q865W3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7EC85279FC6CD0C7	FASTA	2,013	226,773
	10 20 30 40 50 60 MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE APRPQLDLQA 70 80 90 100 110 120 SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV 130 140 150 160 170 180 RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG 190 200 210 220 230 240 FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV 250 260 270 280 290 300 GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV 310 320 330 340 350 360 WESLDHYLSD SGNYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW 370 380 390 400 410 420 AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN 430 440 450 460 470 480 QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT THERRSKRRK 490 500 510 520 530 540 RMSSGTEECG DDRFPKSDSE DGPRAMNRLS STHGLSRTSV KPRSSRGSIF TFRRRDLGSE 550 560 570 580 590 600 TDFADDENST AGDSESHRTS LLVPWPLRQP SAQGQLSPGT SAPALNGKRN STVDCNGVVS 610 620 630 640 650 660 LLGAGDLEAT SPGSHLLRPV ILDRPPDTTT PSEEPGRPQM LTPQAPCVDG FEEPGERQRA 670 680 690 700 710 720 LSAVSVLTSA LEELEESHRK CPPCWNRFAQ RYLIWECCPL WMSIKQRVKF MVMDPFADLT 730 740 750 760 770 780 ITMCIVLNTL FMALEHYNMT AEFEEMLQVG NLVFTGIFTA EMTFKIIALD PYYYFQQGWN 790 800 810 820 830 840 IFDSIIVILS LMELGLSRMG NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL 850 860 870 880 890 900 TLVLAIIVFI FAVVGMQLFG KNYSEQRHRI SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 910 920 930 940 950 960 ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP DDDGEMNNLQ 970 980 990 1000 1010 1020 LALARIQRGL RFLKRTTWDF CCGLLQRPPK PTALAAHGQL PGCMATSSSP PPPESQKVPP 1030 1040 1050 1060 1070 1080 ARKETRFEED KQPGQGTPGD TEPVCVPIAM AESDTDDQEE DEENSLGTEE ESSKQQESQP 1090 1100 1110 1120 1130 1140 VSGSPEAVPE RGAWSQVSET ASSEASVAQA DWRQQRKVEP PAPGCSEAPE DSYSEGSTAD 1150 1160 1170 1180 1190 1200 MTNTADLLEQ IPDLGEDVKD PEDCFTEGCV RRCPCCAVDT TQAPGKVWWR LRKTCYRIVE 1210 1220 1230 1240 1250 1260 HSWFETFIIF MILLSSGALA FEDIYLEERK TIKVLLEYAD KMFTYIFVLE MLLKWVAYGF 1270 1280 1290 1300 1310 1320 KKYFTNAWCW LDFLIVDVSL ISLVANTLGF AEMGPIKSLR TLRALRPLRA LSRFEGMRVV 1330 1340 1350 1360 1370 1380 VNALVGAIPS IMNVLLVCLI FWLIFSIMGV NMFAGKFGRC INQTEGDLPL NYTVVNNKSD 1390 1400 1410 1420 1430 1440 CESFNVTGEL YWTKVKVNFD NVGAGYLALL QVATFKGWMD IMYAAVDSRG FEEQPQWEYN 1450 1460 1470 1480 1490 1500 LYMYIYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS 1510 1520 1530 1540 1550 1560 KKPQKPIPRP LNKYQGFLFD IVTKQAFDVT IMFLICLNMV TMMVETDDQS PEKVNILAKI 1570 1580 1590 1600 1610 1620 NLLFVAIFTG ECIIKMAALR HYYFTNSWNI FDFVVVILSI VGTVLSDIIQ KYFFSPTLFR 1630 1640 1650 1660 1670 1680 VIRLARIGRI LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI FGMANFAYVK 1690 1700 1710 1720 1730 1740 WEAGIDDMFN FQTFANSMLC LFQITTSAGW DGLLSPILNT GPPYCDPNLP NSNGSRGNCG 1750 1760 1770 1780 1790 1800 SPAVGILFFT TYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFDM FYEIWEKFDP 1810 1820 1830 1840 1850 1860 EATQFIEYSA LSDFADALSE PLRIAKPNQI SLINMDLPMV SGDRIHCMDI LFAFTKRVLG 1870 1880 1890 1900 1910 1920 ESGEMDALKI QMEEKFMAAN PSKISYEPIT TTLRRKHEEV SATVIQRAFR RHLLQRSVKH 1930 1940 1950 1960 1970 1980 ASFLYRQQAG GARSGERAPE REGLIAYTMA ENFSRRLGPP SSSSISSTSS PPSYDSVTRA 1990 2000 2010 TSDNPQVRAS DYSRSEDLAD LPPSPDRDRE SIV

References

[1]

"Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles." Haufe V., Cordeiro J.M., Zimmer T., Wu Y.S., Schiccitano S., Benndorf K., Dumaine R. Cardiovasc. Res. 65:117-127(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL CAD88248.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ555547 mRNA. Translation: CAD88248.1.
RefSeq	NP_001002994.1. NM_001002994.1.
UniGene	Cfa.209.
3D structure databases
HSSP	HSSP built from PDB template 1BYY based on UniProtKB P04775.
ProteinModelPortal	Q865W3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403497.
KEGG	cfa:403497.
Organism-specific databases
CTD	6331.
Phylogenomic databases
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
InParanoid	Q865W3.
KO	K04838.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR008053. Na_channel_a5su. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL. PR01666. NACHANNEL5.
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20817011.

Entry information

Entry name

Q865W3_CANFA

Accession

Primary (citable) accession number: Q865W3

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)