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Q865W3

- Q865W3_CANFA

UniProt

Q865W3 - Q865W3_CANFA

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Protein
Sodium channel protein
Gene
scn5A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:scn5AImported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ865W3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ865W3.
KOiK04838.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q865W3-1 [UniParc]FASTAAdd to Basket

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MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE     50
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK 100
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ 150
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV 200
IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL 250
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV 300
WESLDHYLSD SGNYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH 350
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG 400
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI 450
RGVDTVSRSS LEMSPLAPVT THERRSKRRK RMSSGTEECG DDRFPKSDSE 500
DGPRAMNRLS STHGLSRTSV KPRSSRGSIF TFRRRDLGSE TDFADDENST 550
AGDSESHRTS LLVPWPLRQP SAQGQLSPGT SAPALNGKRN STVDCNGVVS 600
LLGAGDLEAT SPGSHLLRPV ILDRPPDTTT PSEEPGRPQM LTPQAPCVDG 650
FEEPGERQRA LSAVSVLTSA LEELEESHRK CPPCWNRFAQ RYLIWECCPL 700
WMSIKQRVKF MVMDPFADLT ITMCIVLNTL FMALEHYNMT AEFEEMLQVG 750
NLVFTGIFTA EMTFKIIALD PYYYFQQGWN IFDSIIVILS LMELGLSRMG 800
NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI 850
FAVVGMQLFG KNYSEQRHRI SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 900
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP 950
DDDGEMNNLQ LALARIQRGL RFLKRTTWDF CCGLLQRPPK PTALAAHGQL 1000
PGCMATSSSP PPPESQKVPP ARKETRFEED KQPGQGTPGD TEPVCVPIAM 1050
AESDTDDQEE DEENSLGTEE ESSKQQESQP VSGSPEAVPE RGAWSQVSET 1100
ASSEASVAQA DWRQQRKVEP PAPGCSEAPE DSYSEGSTAD MTNTADLLEQ 1150
IPDLGEDVKD PEDCFTEGCV RRCPCCAVDT TQAPGKVWWR LRKTCYRIVE 1200
HSWFETFIIF MILLSSGALA FEDIYLEERK TIKVLLEYAD KMFTYIFVLE 1250
MLLKWVAYGF KKYFTNAWCW LDFLIVDVSL ISLVANTLGF AEMGPIKSLR 1300
TLRALRPLRA LSRFEGMRVV VNALVGAIPS IMNVLLVCLI FWLIFSIMGV 1350
NMFAGKFGRC INQTEGDLPL NYTVVNNKSD CESFNVTGEL YWTKVKVNFD 1400
NVGAGYLALL QVATFKGWMD IMYAAVDSRG FEEQPQWEYN LYMYIYFVIF 1450
IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS 1500
KKPQKPIPRP LNKYQGFLFD IVTKQAFDVT IMFLICLNMV TMMVETDDQS 1550
PEKVNILAKI NLLFVAIFTG ECIIKMAALR HYYFTNSWNI FDFVVVILSI 1600
VGTVLSDIIQ KYFFSPTLFR VIRLARIGRI LRLIRGAKGI RTLLFALMMS 1650
LPALFNIGLL LFLVMFIYSI FGMANFAYVK WEAGIDDMFN FQTFANSMLC 1700
LFQITTSAGW DGLLSPILNT GPPYCDPNLP NSNGSRGNCG SPAVGILFFT 1750
TYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFDM FYEIWEKFDP 1800
EATQFIEYSA LSDFADALSE PLRIAKPNQI SLINMDLPMV SGDRIHCMDI 1850
LFAFTKRVLG ESGEMDALKI QMEEKFMAAN PSKISYEPIT TTLRRKHEEV 1900
SATVIQRAFR RHLLQRSVKH ASFLYRQQAG GARSGERAPE REGLIAYTMA 1950
ENFSRRLGPP SSSSISSTSS PPSYDSVTRA TSDNPQVRAS DYSRSEDLAD 2000
LPPSPDRDRE SIV 2013
Length:2,013
Mass (Da):226,773
Last modified:June 1, 2003 - v1
Checksum:i7EC85279FC6CD0C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ555547 mRNA. Translation: CAD88248.1.
RefSeqiNP_001002994.1. NM_001002994.1.
XP_005634204.1. XM_005634147.1.
UniGeneiCfa.209.

Genome annotation databases

GeneIDi403497.
KEGGicfa:403497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ555547 mRNA. Translation: CAD88248.1 .
RefSeqi NP_001002994.1. NM_001002994.1.
XP_005634204.1. XM_005634147.1.
UniGenei Cfa.209.

3D structure databases

ProteinModelPortali Q865W3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403497.
KEGGi cfa:403497.

Organism-specific databases

CTDi 6331.

Phylogenomic databases

HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q865W3.
KOi K04838.

Miscellaneous databases

NextBioi 20817011.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles."
    Haufe V., Cordeiro J.M., Zimmer T., Wu Y.S., Schiccitano S., Benndorf K., Dumaine R.
    Cardiovasc. Res. 65:117-127(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.

Entry informationi

Entry nameiQ865W3_CANFA
AccessioniPrimary (citable) accession number: Q865W3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

External Data

Dasty 3

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