Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q865W3 (Q865W3_CANFA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length2013 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity. RuleBase RU361132

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU361132.

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification] RuleBase RU361132

Caution

Lacks conserved residue(s) required for the propagation of feature annotation. RuleBase RU361132

Sequences

Sequence LengthMass (Da)Tools
Q865W3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7EC85279FC6CD0C7

FASTA2,013226,773
        10         20         30         40         50         60 
MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE APRPQLDLQA 

        70         80         90        100        110        120 
SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV 

       130        140        150        160        170        180 
RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG 

       190        200        210        220        230        240 
FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV 

       250        260        270        280        290        300 
GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV 

       310        320        330        340        350        360 
WESLDHYLSD SGNYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW 

       370        380        390        400        410        420 
AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN 

       430        440        450        460        470        480 
QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT THERRSKRRK 

       490        500        510        520        530        540 
RMSSGTEECG DDRFPKSDSE DGPRAMNRLS STHGLSRTSV KPRSSRGSIF TFRRRDLGSE 

       550        560        570        580        590        600 
TDFADDENST AGDSESHRTS LLVPWPLRQP SAQGQLSPGT SAPALNGKRN STVDCNGVVS 

       610        620        630        640        650        660 
LLGAGDLEAT SPGSHLLRPV ILDRPPDTTT PSEEPGRPQM LTPQAPCVDG FEEPGERQRA 

       670        680        690        700        710        720 
LSAVSVLTSA LEELEESHRK CPPCWNRFAQ RYLIWECCPL WMSIKQRVKF MVMDPFADLT 

       730        740        750        760        770        780 
ITMCIVLNTL FMALEHYNMT AEFEEMLQVG NLVFTGIFTA EMTFKIIALD PYYYFQQGWN 

       790        800        810        820        830        840 
IFDSIIVILS LMELGLSRMG NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL 

       850        860        870        880        890        900 
TLVLAIIVFI FAVVGMQLFG KNYSEQRHRI SDSGLLPRWH MMDFFHAFLI IFRILCGEWI 

       910        920        930        940        950        960 
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP DDDGEMNNLQ 

       970        980        990       1000       1010       1020 
LALARIQRGL RFLKRTTWDF CCGLLQRPPK PTALAAHGQL PGCMATSSSP PPPESQKVPP 

      1030       1040       1050       1060       1070       1080 
ARKETRFEED KQPGQGTPGD TEPVCVPIAM AESDTDDQEE DEENSLGTEE ESSKQQESQP 

      1090       1100       1110       1120       1130       1140 
VSGSPEAVPE RGAWSQVSET ASSEASVAQA DWRQQRKVEP PAPGCSEAPE DSYSEGSTAD 

      1150       1160       1170       1180       1190       1200 
MTNTADLLEQ IPDLGEDVKD PEDCFTEGCV RRCPCCAVDT TQAPGKVWWR LRKTCYRIVE 

      1210       1220       1230       1240       1250       1260 
HSWFETFIIF MILLSSGALA FEDIYLEERK TIKVLLEYAD KMFTYIFVLE MLLKWVAYGF 

      1270       1280       1290       1300       1310       1320 
KKYFTNAWCW LDFLIVDVSL ISLVANTLGF AEMGPIKSLR TLRALRPLRA LSRFEGMRVV 

      1330       1340       1350       1360       1370       1380 
VNALVGAIPS IMNVLLVCLI FWLIFSIMGV NMFAGKFGRC INQTEGDLPL NYTVVNNKSD 

      1390       1400       1410       1420       1430       1440 
CESFNVTGEL YWTKVKVNFD NVGAGYLALL QVATFKGWMD IMYAAVDSRG FEEQPQWEYN 

      1450       1460       1470       1480       1490       1500 
LYMYIYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS 

      1510       1520       1530       1540       1550       1560 
KKPQKPIPRP LNKYQGFLFD IVTKQAFDVT IMFLICLNMV TMMVETDDQS PEKVNILAKI 

      1570       1580       1590       1600       1610       1620 
NLLFVAIFTG ECIIKMAALR HYYFTNSWNI FDFVVVILSI VGTVLSDIIQ KYFFSPTLFR 

      1630       1640       1650       1660       1670       1680 
VIRLARIGRI LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI FGMANFAYVK 

      1690       1700       1710       1720       1730       1740 
WEAGIDDMFN FQTFANSMLC LFQITTSAGW DGLLSPILNT GPPYCDPNLP NSNGSRGNCG 

      1750       1760       1770       1780       1790       1800 
SPAVGILFFT TYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFDM FYEIWEKFDP 

      1810       1820       1830       1840       1850       1860 
EATQFIEYSA LSDFADALSE PLRIAKPNQI SLINMDLPMV SGDRIHCMDI LFAFTKRVLG 

      1870       1880       1890       1900       1910       1920 
ESGEMDALKI QMEEKFMAAN PSKISYEPIT TTLRRKHEEV SATVIQRAFR RHLLQRSVKH 

      1930       1940       1950       1960       1970       1980 
ASFLYRQQAG GARSGERAPE REGLIAYTMA ENFSRRLGPP SSSSISSTSS PPSYDSVTRA 

      1990       2000       2010 
TSDNPQVRAS DYSRSEDLAD LPPSPDRDRE SIV 

« Hide

References

[1]"Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles."
Haufe V., Cordeiro J.M., Zimmer T., Wu Y.S., Schiccitano S., Benndorf K., Dumaine R.
Cardiovasc. Res. 65:117-127(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Heart EMBL CAD88248.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ555547 mRNA. Translation: CAD88248.1.
RefSeqNP_001002994.1. NM_001002994.1.
XP_005634204.1. XM_005634147.1.
UniGeneCfa.209.

3D structure databases

ProteinModelPortalQ865W3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403497.
KEGGcfa:403497.

Organism-specific databases

CTD6331.

Phylogenomic databases

HOGENOMHOG000231755.
HOVERGENHBG053100.
InParanoidQ865W3.
KOK04838.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSPR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817011.

Entry information

Entry nameQ865W3_CANFA
AccessionPrimary (citable) accession number: Q865W3
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)