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Protein

Sodium channel protein

Gene

scn5A

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:scn5AImported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei127 – 14923HelicalUniRule annotationAdd
BLAST
Transmembranei198 – 21821HelicalUniRule annotationAdd
BLAST
Transmembranei230 – 24718HelicalUniRule annotationAdd
BLAST
Transmembranei253 – 27321HelicalUniRule annotationAdd
BLAST
Transmembranei388 – 41629HelicalUniRule annotationAdd
BLAST
Transmembranei716 – 73419HelicalUniRule annotationAdd
BLAST
Transmembranei746 – 76722HelicalUniRule annotationAdd
BLAST
Transmembranei779 – 79618HelicalUniRule annotationAdd
BLAST
Transmembranei836 – 85924HelicalUniRule annotationAdd
BLAST
Transmembranei879 – 89618HelicalUniRule annotationAdd
BLAST
Transmembranei916 – 93924HelicalUniRule annotationAdd
BLAST
Transmembranei1202 – 122120HelicalUniRule annotationAdd
BLAST
Transmembranei1242 – 125817HelicalUniRule annotationAdd
BLAST
Transmembranei1270 – 129122HelicalUniRule annotationAdd
BLAST
Transmembranei1319 – 134527HelicalUniRule annotationAdd
BLAST
Transmembranei1441 – 146727HelicalUniRule annotationAdd
BLAST
Transmembranei1526 – 154419HelicalUniRule annotationAdd
BLAST
Transmembranei1556 – 157419HelicalUniRule annotationAdd
BLAST
Transmembranei1586 – 160621HelicalUniRule annotationAdd
BLAST
Transmembranei1643 – 167129HelicalUniRule annotationAdd
BLAST
Transmembranei1746 – 176924HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ865W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04838.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF178. PTHR10037:SF178. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q865W3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE
60 70 80 90 100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV
310 320 330 340 350
WESLDHYLSD SGNYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
460 470 480 490 500
RGVDTVSRSS LEMSPLAPVT THERRSKRRK RMSSGTEECG DDRFPKSDSE
510 520 530 540 550
DGPRAMNRLS STHGLSRTSV KPRSSRGSIF TFRRRDLGSE TDFADDENST
560 570 580 590 600
AGDSESHRTS LLVPWPLRQP SAQGQLSPGT SAPALNGKRN STVDCNGVVS
610 620 630 640 650
LLGAGDLEAT SPGSHLLRPV ILDRPPDTTT PSEEPGRPQM LTPQAPCVDG
660 670 680 690 700
FEEPGERQRA LSAVSVLTSA LEELEESHRK CPPCWNRFAQ RYLIWECCPL
710 720 730 740 750
WMSIKQRVKF MVMDPFADLT ITMCIVLNTL FMALEHYNMT AEFEEMLQVG
760 770 780 790 800
NLVFTGIFTA EMTFKIIALD PYYYFQQGWN IFDSIIVILS LMELGLSRMG
810 820 830 840 850
NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI
860 870 880 890 900
FAVVGMQLFG KNYSEQRHRI SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
910 920 930 940 950
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP
960 970 980 990 1000
DDDGEMNNLQ LALARIQRGL RFLKRTTWDF CCGLLQRPPK PTALAAHGQL
1010 1020 1030 1040 1050
PGCMATSSSP PPPESQKVPP ARKETRFEED KQPGQGTPGD TEPVCVPIAM
1060 1070 1080 1090 1100
AESDTDDQEE DEENSLGTEE ESSKQQESQP VSGSPEAVPE RGAWSQVSET
1110 1120 1130 1140 1150
ASSEASVAQA DWRQQRKVEP PAPGCSEAPE DSYSEGSTAD MTNTADLLEQ
1160 1170 1180 1190 1200
IPDLGEDVKD PEDCFTEGCV RRCPCCAVDT TQAPGKVWWR LRKTCYRIVE
1210 1220 1230 1240 1250
HSWFETFIIF MILLSSGALA FEDIYLEERK TIKVLLEYAD KMFTYIFVLE
1260 1270 1280 1290 1300
MLLKWVAYGF KKYFTNAWCW LDFLIVDVSL ISLVANTLGF AEMGPIKSLR
1310 1320 1330 1340 1350
TLRALRPLRA LSRFEGMRVV VNALVGAIPS IMNVLLVCLI FWLIFSIMGV
1360 1370 1380 1390 1400
NMFAGKFGRC INQTEGDLPL NYTVVNNKSD CESFNVTGEL YWTKVKVNFD
1410 1420 1430 1440 1450
NVGAGYLALL QVATFKGWMD IMYAAVDSRG FEEQPQWEYN LYMYIYFVIF
1460 1470 1480 1490 1500
IIFGSFFTLN LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS
1510 1520 1530 1540 1550
KKPQKPIPRP LNKYQGFLFD IVTKQAFDVT IMFLICLNMV TMMVETDDQS
1560 1570 1580 1590 1600
PEKVNILAKI NLLFVAIFTG ECIIKMAALR HYYFTNSWNI FDFVVVILSI
1610 1620 1630 1640 1650
VGTVLSDIIQ KYFFSPTLFR VIRLARIGRI LRLIRGAKGI RTLLFALMMS
1660 1670 1680 1690 1700
LPALFNIGLL LFLVMFIYSI FGMANFAYVK WEAGIDDMFN FQTFANSMLC
1710 1720 1730 1740 1750
LFQITTSAGW DGLLSPILNT GPPYCDPNLP NSNGSRGNCG SPAVGILFFT
1760 1770 1780 1790 1800
TYIIISFLIV VNMYIAIILE NFSVATEEST EPLSEDDFDM FYEIWEKFDP
1810 1820 1830 1840 1850
EATQFIEYSA LSDFADALSE PLRIAKPNQI SLINMDLPMV SGDRIHCMDI
1860 1870 1880 1890 1900
LFAFTKRVLG ESGEMDALKI QMEEKFMAAN PSKISYEPIT TTLRRKHEEV
1910 1920 1930 1940 1950
SATVIQRAFR RHLLQRSVKH ASFLYRQQAG GARSGERAPE REGLIAYTMA
1960 1970 1980 1990 2000
ENFSRRLGPP SSSSISSTSS PPSYDSVTRA TSDNPQVRAS DYSRSEDLAD
2010
LPPSPDRDRE SIV
Length:2,013
Mass (Da):226,773
Last modified:June 1, 2003 - v1
Checksum:i7EC85279FC6CD0C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555547 mRNA. Translation: CAD88248.1.
RefSeqiNP_001002994.1. NM_001002994.1.
XP_005634204.1. XM_005634147.1.
UniGeneiCfa.209.

Genome annotation databases

GeneIDi403497.
KEGGicfa:403497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ555547 mRNA. Translation: CAD88248.1.
RefSeqiNP_001002994.1. NM_001002994.1.
XP_005634204.1. XM_005634147.1.
UniGeneiCfa.209.

3D structure databases

ProteinModelPortaliQ865W3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403497.
KEGGicfa:403497.

Organism-specific databases

CTDi6331.

Phylogenomic databases

HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04838.

Miscellaneous databases

NextBioi20817011.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008053. Na_channel_a5su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF178. PTHR10037:SF178. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01666. NACHANNEL5.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles."
    Haufe V., Cordeiro J.M., Zimmer T., Wu Y.S., Schiccitano S., Benndorf K., Dumaine R.
    Cardiovasc. Res. 65:117-127(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.

Entry informationi

Entry nameiQ865W3_CANFA
AccessioniPrimary (citable) accession number: Q865W3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.