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Protein

Macrophage-capping protein

Gene

CAPG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-capping protein
Alternative name(s):
Actin regulatory protein CAP-G
Gene namesi
Name:CAPG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Macrophage-capping proteinPRO_0000284657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei338 – 3381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ865V6.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007150.

Structurei

3D structure databases

ProteinModelPortaliQ865V6.
SMRiQ865V6. Positions 11-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 7549Gelsolin-like 1Add
BLAST
Repeati149 – 18941Gelsolin-like 2Add
BLAST
Repeati262 – 30847Gelsolin-like 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 14710Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 3 gelsolin-like repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000235030.
HOVERGENiHBG001093.
InParanoidiQ865V6.
KOiK10368.
OMAiTERALNW.
OrthoDBiEOG7288RJ.
TreeFamiTF313468.

Family and domain databases

Gene3Di3.40.20.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029917. CapG.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF13. PTHR11977:SF13. 1 hit.
PfamiPF00626. Gelsolin. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q865V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSPIPQSGS PFPPTVKLPG LHIWRVEKLK PVPVAPENYG IFFSGDSYLV
60 70 80 90 100
LHNGPEELSH LHLWIGQQSS RDEQGGCAIL AVHLNTLLGE RPVQHRESQG
110 120 130 140 150
NESDLFMSYF PHGLKYQEGG VESAFHKTSP GTAPAAIKKL YQVKGKKNIR
160 170 180 190 200
ATERVLSWDS FNTGDCFILD LGQNIFAWCG AKSNILERNK ARDLALAIRD
210 220 230 240 250
SERQGKAHVE IVTDGEEPAD MIQVLGPKPS LKEGNPEEDL TADRTNAQAA
260 270 280 290 300
ALYKVSDATG QMNLTKLADS SPFALELLIP DDCFVLDNGL CGKIYIWKGR
310 320 330 340
KANEKERQAA LQVAEDFITR MRYAPNTQVE ILPQGRESAI FKQFFKDWK
Length:349
Mass (Da):38,876
Last modified:June 1, 2003 - v1
Checksum:i981690E3A3DFE4D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219899 mRNA. Translation: AAO38847.1.
BC102160 mRNA. Translation: AAI02161.1.
RefSeqiNP_848669.1. NM_178574.2.
XP_005212800.1. XM_005212743.2.
XP_015328964.1. XM_015473478.1.
UniGeneiBt.5499.

Genome annotation databases

EnsembliENSBTAT00000007150; ENSBTAP00000007150; ENSBTAG00000005432.
GeneIDi353121.
KEGGibta:353121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219899 mRNA. Translation: AAO38847.1.
BC102160 mRNA. Translation: AAI02161.1.
RefSeqiNP_848669.1. NM_178574.2.
XP_005212800.1. XM_005212743.2.
XP_015328964.1. XM_015473478.1.
UniGeneiBt.5499.

3D structure databases

ProteinModelPortaliQ865V6.
SMRiQ865V6. Positions 11-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007150.

Proteomic databases

PaxDbiQ865V6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007150; ENSBTAP00000007150; ENSBTAG00000005432.
GeneIDi353121.
KEGGibta:353121.

Organism-specific databases

CTDi822.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000235030.
HOVERGENiHBG001093.
InParanoidiQ865V6.
KOiK10368.
OMAiTERALNW.
OrthoDBiEOG7288RJ.
TreeFamiTF313468.

Family and domain databases

Gene3Di3.40.20.10. 3 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR029917. CapG.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF13. PTHR11977:SF13. 1 hit.
PfamiPF00626. Gelsolin. 3 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress."
    Pellieux C., Desgeorges A., Pigeon C.H., Chambaz C., Yin H., Hayoz D., Silacci P.
    J. Biol. Chem. 278:29136-29144(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCAPG_BOVIN
AccessioniPrimary (citable) accession number: Q865V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.