Reviewed,
UniProtKB/Swiss-Prot Q865R3 (BASI_BOVIN)
Last modified
October 13, 2009.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Basigin Alternative name(s): EMMPRIN CD_antigen=CD147 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 205 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes By similarity. |
| Subunit structure | Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with AJAP1, ATP1B2, MAG and L1CAM By similarity. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein By similarity. Melanosome By similarity. Note: Colocalizes with SLC16A1 and SLC16A8 By similarity. |
| Sequence similarities | Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Immunoglobulin domain Signal |
| Ligand | Lectin Mannose-binding |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | mannose binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | By similarity | ||||||||
| Chain | 22 – ›205 | ›184 | Basigin | PRO_0000014516 | |||||||
Regions | |||||||||||
| Topological domain | 22 – ›205 | ›184 | Extracellular Potential | ||||||||
| Domain | 22 – 103 | 82 | Ig-like C2-type | ||||||||
| Domain | 105 – 199 | 95 | Ig-like V-type | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 44 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 152 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 186 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 41 ↔ 87 | By similarity | |||||||||
| Disulfide bond | 126 ↔ 185 | By similarity | |||||||||
Experimental info | |||||||||||
| Non-terminal residue | 205 | 1 | |||||||||
Sequences
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References
| [1] | "Expression of EMMPRIN mRNA in bovine endometrium." Sato T., Takita M., Noguchi Y., Konno S., Hirata M., Hashizume K., Ito A. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endometrium. |
Cross-references
Sequence databases | |
|---|---|
| AB091679 mRNA. Translation: BAC67167.1. | |
| IPI | IPI00717356. |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | Q865R3. |
Family and domain databases | |
| InterPro | IPR009151. Basigin. IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 1 hit. |
| Pfam | PF00047. ig. 1 hit. [Graphical view] |
| PRINTS | PR01856. BASIGIN. |
| SMART | SM00409. IG. 1 hit. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BASI_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q865R3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


