Reviewed, UniProtKB/Swiss-Prot Q865R3 (BASI_BOVIN)

Names and origin

Protein names

Recommended name:
    Basigin
Alternative name(s):
    EMMPRIN
    CD_antigen=CD147

Gene names

Name:

BSG

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	205 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes By similarity.
Subunit structure	Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with AJAP1, ATP1B2, MAG and L1CAM By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Melanosome By similarity. Note: Colocalizes with SLC16A1 and SLC16A8 By similarity.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal
Ligand	Lectin Mannose-binding
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	mannose binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – ›205	›184	Basigin		PRO_0000014516
Regions
	Topological domain	22 – ›205	›184	Extracellular Potential
	Domain	22 – 103	82	Ig-like C2-type
	Domain	105 – 199	95	Ig-like V-type
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) By similarity
	Glycosylation	152	1	N-linked (GlcNAc...) By similarity
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 87		By similarity
	Disulfide bond	126 ↔ 185		By similarity
Experimental info
	Non-terminal residue	205	1

Sequences

	Sequence		Length	Mass (Da)
	Q865R3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 15215BD36C5A38C0	FASTA	205	22,119
	10 20 30 40 50 60 MAAALFVLLG FALLGTHGAS GAAGTVFTTV EDLGSKILLT CSLNDSATEV TGHRWLKGGV 70 80 90 100 110 120 VLKEDALPGQ KTEFKVDSDD QWGEYSCVFL PEPMGTANIQ LHGPPRVKAV KSSEHINEGE 130 140 150 160 170 180 TAMLVCKSES VPPVTDWAWY KITDSEDKAL MNGSESRFFV SSSQGRSELH IENLNMEADP 190 200 GQYRCNGTSS KGSDQAIITL RVRSH

References

[1]	"Expression of EMMPRIN mRNA in bovine endometrium." Sato T., Takita M., Noguchi Y., Konno S., Hirata M., Hashizume K., Ito A. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endometrium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB091679 mRNA. Translation: BAC67167.1.
IPI	IPI00717356.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q865R3.
Family and domain databases
InterPro	IPR009151. Basigin. IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF00047. ig. 1 hit. [Graphical view]
PRINTS	PR01856. BASIGIN.
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BASI_BOVIN

Accession

Primary (citable) accession number: Q865R3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	June 1, 2003
Last modified:	October 13, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)