Reviewed,
UniProtKB/Swiss-Prot Q865R1 (PAOX_BOVIN)
Last modified
November 25, 2008.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase EC=1.5.3.11 Alternative name(s): Polyamine oxidase | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 512 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration. |
| Catalytic activity | N(1)-acetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-aminopropanal + H(2)O(2). |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Subcellular location | PeroxisomeBy similarity. CytoplasmBy similarity. |
| Miscellaneous | Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen By similarity. |
| Sequence similarities | Belongs to the flavin monoamine oxidase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Peroxisome |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | electron carrier activity Inferred from electronic annotation. Source: InterPro polyamine oxidase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 6 | 6 | PRO_0000236802 | ||||||
| Chain | 7 – 512 | 506 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | PRO_0000099874 | |||||
Regions | |||||||||
| Motif | 510 – 512 | 3 | Microbody targeting signal Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 7 | 1 | Q → E AA sequence Ref.2 | ||||||
| Sequence conflict | 482 | 1 | T → P in AAN40707. Ref.2 | ||||||
Sequences
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References
| [1] | "Comparative mapping of the bovine SPRN locus." Ferretti L., Uboldi C., Del Vecchio I., Eggen A., Brunner R., Iannuzzi L. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [2] | "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N(1)-acetylated polyamine oxidase." Wu T., Yankovskaya V., McIntire W.S. J. Biol. Chem. 278:20514-20525(2003) [PubMed: 12660232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 62-512, PROTEIN SEQUENCE OF 7-27; 57-76 AND 497-511, CHARACTERIZATION. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| DQ058607 mRNA. Translation: AAY83881.1. DQ058602 Genomic DNA. Translation: AAY83877.1. AF226658 mRNA. Translation: AAN40707.1. | |
| RefSeq | NP_001013620.2. |
| UniGene | Bt.36568 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000018321. Bos taurus. [Contig view] |
| GeneID | 282639. |
| KEGG | bta:282639. |
Phylogenomic databases | |
| HOVERGEN | Q865R1. |
Family and domain databases | |
| InterPro | IPR002937. Amino_oxidase. [Graphical view] |
| Pfam | PF01593. Amino_oxidase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PAOX_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q865R1 Secondary accession number(s): Q4PS79 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


