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Protein

Agouti-signaling protein

Gene

ASIP

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-signaling protein
Short name:
ASP
Alternative name(s):
Agouti switch protein
Gene namesi
Name:ASIP
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000102623 – 135Agouti-signaling proteinAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 111PROSITE-ProRule annotation
Disulfide bondi103 ↔ 117PROSITE-ProRule annotation
Disulfide bondi110 ↔ 128PROSITE-ProRule annotation
Disulfide bondi114 ↔ 135PROSITE-ProRule annotation
Disulfide bondi119 ↔ 126PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ865F0

Expressioni

Gene expression databases

BgeeiENSFCAG00000011037

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ865F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 135AgoutiPROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 88Arg/Lys-rich (basic)Add BLAST32

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

GeneTreeiENSGT00510000048661
HOGENOMiHOG000111779
HOVERGENiHBG050593
InParanoidiQ865F0
KOiK08725
OMAiCSCRVLN
TreeFamiTF330729

Family and domain databases

Gene3Di4.10.760.10, 1 hit
InterProiView protein in InterPro
IPR007733 Agouti
IPR027300 Agouti_dom
IPR036836 Agouti_dom_sf
PANTHERiPTHR16551 PTHR16551, 1 hit
PfamiView protein in Pfam
PF05039 Agouti, 1 hit
SMARTiView protein in SMART
SM00792 Agouti, 1 hit
SUPFAMiSSF57055 SSF57055, 1 hit
PROSITEiView protein in PROSITE
PS60024 AGOUTI_1, 1 hit
PS51150 AGOUTI_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q865F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILRLLLAT LLVCLCLLTA YSHLAPEEKP RDDRNLRSNS SMNMLDLSSV
60 70 80 90 100
SIVALNKKSK KISRKEAEKK RSSKKKASMK NVAQPRRPRP PPPAPCVATR
110 120 130
DSCKPPAPAC CDPCASCQCR FFRSSCSCRV LNPTC
Length:135
Mass (Da):14,948
Last modified:June 1, 2003 - v1
Checksum:iFF748AE9C862E489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237394 Genomic DNA Translation: AAO62411.1
RefSeqiNP_001009190.1, NM_001009190.1
XP_006929845.1, XM_006929783.2
XP_019681722.1, XM_019826163.1
XP_019681723.1, XM_019826164.1
XP_019681724.1, XM_019826165.1
XP_019681725.1, XM_019826166.1
XP_019681726.1, XM_019826167.1
XP_019681727.1, XM_019826168.1
XP_019681728.1, XM_019826169.1

Genome annotation databases

EnsembliENSFCAT00000011040; ENSFCAP00000010252; ENSFCAG00000011037
ENSFCAT00000040140; ENSFCAP00000028653; ENSFCAG00000011037
ENSFCAT00000042686; ENSFCAP00000031630; ENSFCAG00000011037
GeneIDi492297
KEGGifca:492297

Similar proteinsi

Entry informationi

Entry nameiASIP_FELCA
AccessioniPrimary (citable) accession number: Q865F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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