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Q865C0 (CAH6_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbonic anhydrase 6
EC=4.2.1.1
Alternative name(s):
Carbonate dehydratase VI
Carbonic anhydrase VI
Short name=CA-VI
Gene names
Name:CA6
OrganismCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Reversible hydration of carbon dioxide. Its role in saliva is unknown By similarity.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Zinc By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionLyase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 320303Carbonic anhydrase 6
PRO_0000004240

Regions

Region220 – 2212Substrate binding By similarity

Sites

Active site851Proton acceptor By similarity
Active site1461 By similarity
Metal binding1111Zinc; catalytic By similarity
Metal binding1131Zinc; catalytic By similarity
Metal binding1381Zinc; catalytic By similarity

Amino acid modifications

Glycosylation2561N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 224 Potential

Sequences

Sequence LengthMass (Da)Tools
Q865C0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6E00A8D08AA0D23F

FASTA32036,705
        10         20         30         40         50         60 
MRALALLLAL PLLGARAQHG SLWTYSEGAL DQVHWPREYP TCGGTRQSPI DLQRRKVQYN 

        70         80         90        100        110        120 
PSLKALKLTG YRIQVGEFPM INNGHTVQIS LPPTMRMMAS DGTEYIAQQM HFHWGGASSE 

       130        140        150        160        170        180 
ISGSEHTIDG IRFVAEIHIV HYNSKYKSYD IAQHEPDGLA VLAALVKVED YGENTYYSNF 

       190        200        210        220        230        240 
ISHLNNIRYP GQSTVLSGLD IEDMLPENTH HYYTYRGSLT TPPCTENVHW FVLVHHVRLS 

       250        260        270        280        290        300 
SIQTWKLENS ILDHQNKTLH SDYRRIQPLN GRVVESNFVN LPSQGSEFQF YVNKLNNKLE 

       310        320 
YLRRLLEKTK VEKKPHIHQA

« Hide

References

[1]"Canine carbonic anhydrase VI (CA6), mRNA."
Murakami M.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Parotid gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB080972 mRNA. Translation: BAC65098.1.
RefSeqNP_001002999.1. NM_001002999.1.
UniGeneCfa.215.

3D structure databases

ProteinModelPortalQ865C0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403503.
KEGGcfa:403503.

Organism-specific databases

CTD765.

Phylogenomic databases

eggNOGmaNOG16006.
GeneTreeENSGT00570000078862.
HOVERGENHBG002837.
InParanoidQ865C0.
OrthoDBEOG43FGWZ.

Family and domain databases

InterProIPR001148. a_carbonic_anhydrase.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018428. Carbonic_anhydrase_CA6.
[Graphical view]
Gene3DG3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KOK01672.
PANTHERPTHR18952:SF17. Carbonic_anhydrase_CA6. 1 hit.
PTHR18952. Euk_COanhd. 1 hit.
PfamPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMSSF51069. Euk_COanhd. 1 hit.
PROSITEPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAH6_CANFA
AccessionPrimary (citable) accession number: Q865C0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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