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Q865B7

- PRGC1_BOVIN

UniProt

Q865B7 - PRGC1_BOVIN

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Protein
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Gene
PPARGC1A, PGC1, PGC1A, PPARGC1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK By similarity.

GO - Molecular functioni

  1. DNA binding Source: AgBase
  2. RNA binding Source: UniProtKB-KW
  3. chromatin DNA binding Source: UniProtKB
  4. nucleotide binding Source: InterPro
  5. sequence-specific DNA binding Source: UniProtKB
  6. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. cellular response to oxidative stress Source: UniProtKB
  2. circadian regulation of gene expression Source: UniProtKB
  3. negative regulation of neuron apoptotic process Source: UniProtKB
  4. neuron death Source: UniProtKB
  5. positive regulation of ATP biosynthetic process Source: UniProtKB
  6. positive regulation of energy homeostasis Source: UniProtKB
  7. positive regulation of mitochondrion organization Source: UniProtKB
  8. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: AgBase
  10. positive regulation of transcription, DNA-templated Source: AgBase
  11. regulation of cell death Source: UniProtKB
  12. regulation of circadian rhythm Source: UniProtKB
  13. regulation of transcription, DNA-templated Source: UniProtKB
  14. respiratory electron transport chain Source: UniProtKB
  15. response to muscle activity Source: UniProtKB
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_207237. PPARA activates gene expression.
REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
REACT_215625. RORA activates circadian gene expression.
REACT_220799. Transcriptional regulation of white adipocyte differentiation.
REACT_224346. REV-ERBA represses gene expression.
REACT_227144. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Short name:
PGC-1-alpha
Short name:
PPAR-gamma coactivator 1-alpha
Short name:
PPARGC-1-alpha
Gene namesi
Name:PPARGC1A
Synonyms:PGC1, PGC1A, PPARGC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

Nucleus By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. PML body Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
PRO_0000081731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6-acetyllysine By similarity
Modified residuei144 – 1441N6-acetyllysine By similarity
Modified residuei176 – 1761Phosphothreonine; by AMPK By similarity
Modified residuei182 – 1821N6-acetyllysine By similarity
Modified residuei252 – 2521N6-acetyllysine By similarity
Modified residuei269 – 2691N6-acetyllysine By similarity
Modified residuei276 – 2761N6-acetyllysine By similarity
Modified residuei319 – 3191N6-acetyllysine By similarity
Modified residuei345 – 3451N6-acetyllysine By similarity
Modified residuei411 – 4111N6-acetyllysine By similarity
Modified residuei450 – 4501N6-acetyllysine By similarity
Modified residuei538 – 5381Phosphoserine; by AMPK By similarity
Modified residuei756 – 7561N6-acetyllysine By similarity
Modified residuei777 – 7771N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter By similarity. Phosphorylated by CLK2 By similarity.
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ865B7.

Interactioni

Subunit structurei

Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with LRPPRC, PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ865B7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini675 – 75177RRM
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni291 – 33747Interaction with PPARG By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1465LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi565 – 59834Arg/Ser-rich
Add
BLAST
Compositional biasi621 – 63111Arg/Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG78353.
GeneTreeiENSGT00530000063196.
HOGENOMiHOG000037431.
HOVERGENiHBG053678.
InParanoidiQ865B7.
KOiK07202.
OrthoDBiEOG7S4X5H.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q865B7-1 [UniParc]FASTAAdd to Basket

« Hide

MAWDMCNQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL    50
GGLKWCSDQS EIISNQYNNE PSNIFEKIDE ENEANLLAVL TETLDSLPVD 100
EDGLPSFDAL TDGDVTTENE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA 150
NTQLSYNECS GLSTQNHANH NHRIRTNPAV VKTENSWSNK AKSICQQQKP 200
QRRPCSELLK YLTTNDDPPH TKPTENRNSS RDKCTSKKKA HTQSQTQHLQ 250
AKPTTLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH 300
KANQDNPFRA SPKLKPSCKT VVPPPSKKAR YSESSCTQGS NSTKKGPEQS 350
ELYAQLSKTS VLTSGHEERK AKRPSLRLFG DHDYCQSINS KTEILVSTSQ 400
ELHDSRQLEN KDAPSSNGPG QIHSSTDSDP CYLRETAEVS RQVSPGSTRK 450
QLQDQEIRAE LNKHFGHPSQ AVFDDKADKT SELRDSDFSN EQFSKLPMFI 500
NSGLAMDGLF DDSEDESDKL NSPWDGTQSY SLFDVSPSCS SFNSPCRDSV 550
SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 600
YYESGHCRHR THRNSPLCAS RSRSPHSRRP RYDSYEEYQH ERLKREEYRR 650
EYEKRESERA KQRERQRQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE 700
IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG 750
RKQFFKSNYA DLDSNSDDFD PACIKSKYDS LDFDSLLKEA QRSLRR 796
Length:796
Mass (Da):90,309
Last modified:June 1, 2003 - v1
Checksum:i2602BF4DC63D6701
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106107 mRNA. Translation: BAC66018.1.
AY321517 mRNA. Translation: AAQ82595.1.
RefSeqiNP_808814.1. NM_177945.3.
UniGeneiBt.20920.

Genome annotation databases

EnsembliENSBTAT00000022636; ENSBTAP00000022636; ENSBTAG00000017024.
GeneIDi338446.
KEGGibta:338446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB106107 mRNA. Translation: BAC66018.1 .
AY321517 mRNA. Translation: AAQ82595.1 .
RefSeqi NP_808814.1. NM_177945.3.
UniGenei Bt.20920.

3D structure databases

ProteinModelPortali Q865B7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q865B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000022636 ; ENSBTAP00000022636 ; ENSBTAG00000017024 .
GeneIDi 338446.
KEGGi bta:338446.

Organism-specific databases

CTDi 10891.

Phylogenomic databases

eggNOGi NOG78353.
GeneTreei ENSGT00530000063196.
HOGENOMi HOG000037431.
HOVERGENi HBG053678.
InParanoidi Q865B7.
KOi K07202.
OrthoDBi EOG7S4X5H.

Enzyme and pathway databases

Reactomei REACT_207237. PPARA activates gene expression.
REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
REACT_215625. RORA activates circadian gene expression.
REACT_220799. Transcriptional regulation of white adipocyte differentiation.
REACT_224346. REV-ERBA represses gene expression.
REACT_227144. Circadian Clock.

Miscellaneous databases

NextBioi 20812645.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of bovine and swine PGC-1alpha."
    Chikuni K., Muroya S., Nakajima I.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular characterisation of the bovine PPARGC1A gene and association of identified alleles with genetic variation of milk fat synthesis in cattle."
    Weikard R., Kuehn C., Freyer G., Goldammer T., Schwerin M.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPRGC1_BOVIN
AccessioniPrimary (citable) accession number: Q865B7
Secondary accession number(s): Q4L229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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