Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q865B7

- PRGC1_BOVIN

UniProt

Q865B7 - PRGC1_BOVIN

Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene

PPARGC1A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK By similarity.By similarity

    GO - Molecular functioni

    1. chromatin DNA binding Source: UniProtKB
    2. DNA binding Source: AgBase
    3. nucleotide binding Source: InterPro
    4. RNA binding Source: UniProtKB-KW
    5. sequence-specific DNA binding Source: UniProtKB
    6. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to oxidative stress Source: UniProtKB
    2. circadian regulation of gene expression Source: UniProtKB
    3. negative regulation of neuron apoptotic process Source: UniProtKB
    4. neuron death Source: UniProtKB
    5. positive regulation of ATP biosynthetic process Source: UniProtKB
    6. positive regulation of energy homeostasis Source: UniProtKB
    7. positive regulation of mitochondrion organization Source: UniProtKB
    8. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. positive regulation of transcription, DNA-templated Source: AgBase
    10. positive regulation of transcription from RNA polymerase II promoter Source: AgBase
    11. regulation of cell death Source: UniProtKB
    12. regulation of circadian rhythm Source: UniProtKB
    13. regulation of transcription, DNA-templated Source: UniProtKB
    14. respiratory electron transport chain Source: UniProtKB
    15. response to muscle activity Source: UniProtKB
    16. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_207237. PPARA activates gene expression.
    REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
    REACT_214581. Transcriptional activation of mitochondrial biogenesis.
    REACT_215625. RORA activates circadian gene expression.
    REACT_220799. Transcriptional regulation of white adipocyte differentiation.
    REACT_224346. REV-ERBA represses gene expression.
    REACT_227144. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Short name:
    PGC-1-alpha
    Short name:
    PPAR-gamma coactivator 1-alpha
    Short name:
    PPARGC-1-alpha
    Gene namesi
    Name:PPARGC1A
    Synonyms:PGC1, PGC1A, PPARGC1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    Nucleus By similarity. NucleusPML body By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796Peroxisome proliferator-activated receptor gamma coactivator 1-alphaPRO_0000081731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771N6-acetyllysineBy similarity
    Modified residuei144 – 1441N6-acetyllysineBy similarity
    Modified residuei176 – 1761Phosphothreonine; by AMPKBy similarity
    Modified residuei182 – 1821N6-acetyllysineBy similarity
    Modified residuei252 – 2521N6-acetyllysineBy similarity
    Modified residuei269 – 2691N6-acetyllysineBy similarity
    Modified residuei276 – 2761N6-acetyllysineBy similarity
    Modified residuei319 – 3191N6-acetyllysineBy similarity
    Modified residuei345 – 3451N6-acetyllysineBy similarity
    Modified residuei411 – 4111N6-acetyllysineBy similarity
    Modified residuei450 – 4501N6-acetyllysineBy similarity
    Modified residuei538 – 5381Phosphoserine; by AMPKBy similarity
    Modified residuei756 – 7561N6-acetyllysineBy similarity
    Modified residuei777 – 7771N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.By similarity
    Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ865B7.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with LRPPRC, PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ865B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini675 – 75177RRMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni291 – 33747Interaction with PPARGBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi142 – 1465LXXLL motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi565 – 59834Arg/Ser-richAdd
    BLAST
    Compositional biasi621 – 63111Arg/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG78353.
    GeneTreeiENSGT00530000063196.
    HOGENOMiHOG000037431.
    HOVERGENiHBG053678.
    InParanoidiQ865B7.
    KOiK07202.
    OrthoDBiEOG7S4X5H.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q865B7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWDMCNQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL    50
    GGLKWCSDQS EIISNQYNNE PSNIFEKIDE ENEANLLAVL TETLDSLPVD 100
    EDGLPSFDAL TDGDVTTENE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA 150
    NTQLSYNECS GLSTQNHANH NHRIRTNPAV VKTENSWSNK AKSICQQQKP 200
    QRRPCSELLK YLTTNDDPPH TKPTENRNSS RDKCTSKKKA HTQSQTQHLQ 250
    AKPTTLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH 300
    KANQDNPFRA SPKLKPSCKT VVPPPSKKAR YSESSCTQGS NSTKKGPEQS 350
    ELYAQLSKTS VLTSGHEERK AKRPSLRLFG DHDYCQSINS KTEILVSTSQ 400
    ELHDSRQLEN KDAPSSNGPG QIHSSTDSDP CYLRETAEVS RQVSPGSTRK 450
    QLQDQEIRAE LNKHFGHPSQ AVFDDKADKT SELRDSDFSN EQFSKLPMFI 500
    NSGLAMDGLF DDSEDESDKL NSPWDGTQSY SLFDVSPSCS SFNSPCRDSV 550
    SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 600
    YYESGHCRHR THRNSPLCAS RSRSPHSRRP RYDSYEEYQH ERLKREEYRR 650
    EYEKRESERA KQRERQRQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE 700
    IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG 750
    RKQFFKSNYA DLDSNSDDFD PACIKSKYDS LDFDSLLKEA QRSLRR 796
    Length:796
    Mass (Da):90,309
    Last modified:June 1, 2003 - v1
    Checksum:i2602BF4DC63D6701
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB106107 mRNA. Translation: BAC66018.1.
    AY321517 mRNA. Translation: AAQ82595.1.
    RefSeqiNP_808814.1. NM_177945.3.
    UniGeneiBt.20920.

    Genome annotation databases

    EnsembliENSBTAT00000022636; ENSBTAP00000022636; ENSBTAG00000017024.
    GeneIDi338446.
    KEGGibta:338446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB106107 mRNA. Translation: BAC66018.1 .
    AY321517 mRNA. Translation: AAQ82595.1 .
    RefSeqi NP_808814.1. NM_177945.3.
    UniGenei Bt.20920.

    3D structure databases

    ProteinModelPortali Q865B7.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q865B7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000022636 ; ENSBTAP00000022636 ; ENSBTAG00000017024 .
    GeneIDi 338446.
    KEGGi bta:338446.

    Organism-specific databases

    CTDi 10891.

    Phylogenomic databases

    eggNOGi NOG78353.
    GeneTreei ENSGT00530000063196.
    HOGENOMi HOG000037431.
    HOVERGENi HBG053678.
    InParanoidi Q865B7.
    KOi K07202.
    OrthoDBi EOG7S4X5H.

    Enzyme and pathway databases

    Reactomei REACT_207237. PPARA activates gene expression.
    REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
    REACT_214581. Transcriptional activation of mitochondrial biogenesis.
    REACT_215625. RORA activates circadian gene expression.
    REACT_220799. Transcriptional regulation of white adipocyte differentiation.
    REACT_224346. REV-ERBA represses gene expression.
    REACT_227144. Circadian Clock.

    Miscellaneous databases

    NextBioi 20812645.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of bovine and swine PGC-1alpha."
      Chikuni K., Muroya S., Nakajima I.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular characterisation of the bovine PPARGC1A gene and association of identified alleles with genetic variation of milk fat synthesis in cattle."
      Weikard R., Kuehn C., Freyer G., Goldammer T., Schwerin M.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPRGC1_BOVIN
    AccessioniPrimary (citable) accession number: Q865B7
    Secondary accession number(s): Q4L229
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3