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Q865B7

- PRGC1_BOVIN

UniProt

Q865B7 - PRGC1_BOVIN

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Protein

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Gene

PPARGC1A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).By similarity

GO - Molecular functioni

  1. chromatin DNA binding Source: UniProtKB
  2. DNA binding Source: AgBase
  3. nucleotide binding Source: InterPro
  4. RNA binding Source: UniProtKB-KW
  5. sequence-specific DNA binding Source: UniProtKB
  6. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. cellular response to oxidative stress Source: UniProtKB
  2. circadian regulation of gene expression Source: UniProtKB
  3. negative regulation of neuron apoptotic process Source: UniProtKB
  4. negative regulation of neuron death Source: UniProtKB
  5. positive regulation of ATP biosynthetic process Source: UniProtKB
  6. positive regulation of energy homeostasis Source: UniProtKB
  7. positive regulation of mitochondrion organization Source: UniProtKB
  8. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  9. positive regulation of transcription, DNA-templated Source: AgBase
  10. positive regulation of transcription from RNA polymerase II promoter Source: AgBase
  11. regulation of circadian rhythm Source: UniProtKB
  12. regulation of transcription, DNA-templated Source: UniProtKB
  13. respiratory electron transport chain Source: UniProtKB
  14. response to muscle activity Source: UniProtKB
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_207237. PPARA activates gene expression.
REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
REACT_215625. RORA activates circadian gene expression.
REACT_220799. Transcriptional regulation of white adipocyte differentiation.
REACT_224346. REV-ERBA represses gene expression.
REACT_227144. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Short name:
PGC-1-alpha
Short name:
PPAR-gamma coactivator 1-alpha
Short name:
PPARGC-1-alpha
Gene namesi
Name:PPARGC1A
Synonyms:PGC1, PGC1A, PPARGC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

Nucleus By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Peroxisome proliferator-activated receptor gamma coactivator 1-alphaPRO_0000081731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771N6-acetyllysineBy similarity
Modified residuei144 – 1441N6-acetyllysineBy similarity
Modified residuei176 – 1761Phosphothreonine; by AMPKBy similarity
Modified residuei182 – 1821N6-acetyllysineBy similarity
Modified residuei252 – 2521N6-acetyllysineBy similarity
Modified residuei269 – 2691N6-acetyllysineBy similarity
Modified residuei276 – 2761N6-acetyllysineBy similarity
Modified residuei319 – 3191N6-acetyllysineBy similarity
Modified residuei345 – 3451N6-acetyllysineBy similarity
Modified residuei411 – 4111N6-acetyllysineBy similarity
Modified residuei450 – 4501N6-acetyllysineBy similarity
Modified residuei538 – 5381Phosphoserine; by AMPKBy similarity
Modified residuei756 – 7561N6-acetyllysineBy similarity
Modified residuei777 – 7771N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.By similarity
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions (By similarity).By similarity
Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ865B7.

Expressioni

Gene expression databases

ExpressionAtlasiQ865B7. baseline.

Interactioni

Subunit structurei

Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ865B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini675 – 75177RRMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni291 – 33747Interaction with PPARGBy similarityAdd
BLAST
Regioni348 – 796449Mediates interaction with RNF34By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1465LXXLL motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi565 – 59834Arg/Ser-richAdd
BLAST
Compositional biasi621 – 63111Arg/Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG78353.
GeneTreeiENSGT00530000063196.
HOGENOMiHOG000037431.
HOVERGENiHBG053678.
InParanoidiQ865B7.
KOiK07202.
OrthoDBiEOG7S4X5H.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q865B7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWDMCNQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL
60 70 80 90 100
GGLKWCSDQS EIISNQYNNE PSNIFEKIDE ENEANLLAVL TETLDSLPVD
110 120 130 140 150
EDGLPSFDAL TDGDVTTENE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA
160 170 180 190 200
NTQLSYNECS GLSTQNHANH NHRIRTNPAV VKTENSWSNK AKSICQQQKP
210 220 230 240 250
QRRPCSELLK YLTTNDDPPH TKPTENRNSS RDKCTSKKKA HTQSQTQHLQ
260 270 280 290 300
AKPTTLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH
310 320 330 340 350
KANQDNPFRA SPKLKPSCKT VVPPPSKKAR YSESSCTQGS NSTKKGPEQS
360 370 380 390 400
ELYAQLSKTS VLTSGHEERK AKRPSLRLFG DHDYCQSINS KTEILVSTSQ
410 420 430 440 450
ELHDSRQLEN KDAPSSNGPG QIHSSTDSDP CYLRETAEVS RQVSPGSTRK
460 470 480 490 500
QLQDQEIRAE LNKHFGHPSQ AVFDDKADKT SELRDSDFSN EQFSKLPMFI
510 520 530 540 550
NSGLAMDGLF DDSEDESDKL NSPWDGTQSY SLFDVSPSCS SFNSPCRDSV
560 570 580 590 600
SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY
610 620 630 640 650
YYESGHCRHR THRNSPLCAS RSRSPHSRRP RYDSYEEYQH ERLKREEYRR
660 670 680 690 700
EYEKRESERA KQRERQRQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE
710 720 730 740 750
IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG
760 770 780 790
RKQFFKSNYA DLDSNSDDFD PACIKSKYDS LDFDSLLKEA QRSLRR
Length:796
Mass (Da):90,309
Last modified:June 1, 2003 - v1
Checksum:i2602BF4DC63D6701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB106107 mRNA. Translation: BAC66018.1.
AY321517 mRNA. Translation: AAQ82595.1.
RefSeqiNP_808814.1. NM_177945.3.
UniGeneiBt.20920.

Genome annotation databases

EnsembliENSBTAT00000022636; ENSBTAP00000022636; ENSBTAG00000017024.
GeneIDi338446.
KEGGibta:338446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB106107 mRNA. Translation: BAC66018.1 .
AY321517 mRNA. Translation: AAQ82595.1 .
RefSeqi NP_808814.1. NM_177945.3.
UniGenei Bt.20920.

3D structure databases

ProteinModelPortali Q865B7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q865B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000022636 ; ENSBTAP00000022636 ; ENSBTAG00000017024 .
GeneIDi 338446.
KEGGi bta:338446.

Organism-specific databases

CTDi 10891.

Phylogenomic databases

eggNOGi NOG78353.
GeneTreei ENSGT00530000063196.
HOGENOMi HOG000037431.
HOVERGENi HBG053678.
InParanoidi Q865B7.
KOi K07202.
OrthoDBi EOG7S4X5H.

Enzyme and pathway databases

Reactomei REACT_207237. PPARA activates gene expression.
REACT_210271. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_212213. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
REACT_215625. RORA activates circadian gene expression.
REACT_220799. Transcriptional regulation of white adipocyte differentiation.
REACT_224346. REV-ERBA represses gene expression.
REACT_227144. Circadian Clock.

Miscellaneous databases

NextBioi 20812645.

Gene expression databases

ExpressionAtlasi Q865B7. baseline.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of bovine and swine PGC-1alpha."
    Chikuni K., Muroya S., Nakajima I.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular characterisation of the bovine PPARGC1A gene and association of identified alleles with genetic variation of milk fat synthesis in cattle."
    Weikard R., Kuehn C., Freyer G., Goldammer T., Schwerin M.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPRGC1_BOVIN
AccessioniPrimary (citable) accession number: Q865B7
Secondary accession number(s): Q4L229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3