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Q864W1 (CFAB_PONPY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Complement factor B
EC=3.4.21.47
Alternative name(s):
C3/C5 convertase

Cleaved into the following 2 chains:

  1. Complement factor B Ba fragment
  2. Complement factor B Bb fragment
Gene names
Name:CFB
Synonyms:BF
OrganismPongo pygmaeus (Bornean orangutan)
Taxonomic identifier9600 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length764 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes By similarity.

Catalytic activity

Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Contains 3 Sushi (CCP/SCR) domains.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 By similarity
Chain26 – 764739Complement factor B
PRO_0000027554
Chain26 – 259234Complement factor B Ba fragment
PRO_0000027555
Chain260 – 764505Complement factor B Bb fragment
PRO_0000027556

Regions

Domain35 – 10066Sushi 1
Domain101 – 16060Sushi 2
Domain163 – 22058Sushi 3
Domain270 – 469200VWFA
Domain477 – 757281Peptidase S1

Sites

Active site5261Charge relay system By similarity
Active site5761Charge relay system By similarity
Active site6991Charge relay system By similarity

Amino acid modifications

Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Disulfide bond37 ↔ 76 By similarity
Disulfide bond62 ↔ 98 By similarity
Disulfide bond103 ↔ 145 By similarity
Disulfide bond131 ↔ 158 By similarity
Disulfide bond165 ↔ 205 By similarity
Disulfide bond191 ↔ 218 By similarity
Disulfide bond511 ↔ 527 By similarity
Disulfide bond695 ↔ 725 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q864W1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2FFA047D6C34E6EB

FASTA76485,489
        10         20         30         40         50         60 
MGSNLSPQLC LMPFILGLLS GGVTTTPLSL ARSQGSCSLE GIEIKGGSFR LLQDGQALEY 

        70         80         90        100        110        120 
VCPSGFYPYP VQTRTCRSTG SWSTLQTQDQ KTVKKAECRA IHCPRPHDFE NGEYWPRSPY 

       130        140        150        160        170        180 
YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ 

       190        200        210        220        230        240 
YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE 

       250        260        270        280        290        300 
TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGAGNFTGAK KCLVNLIEKV 

       310        320        330        340        350        360 
ASYGVKPRYG LVTYATYPKI WVKVSEPDSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ 

       370        380        390        400        410        420 
AVYSMMSWPD DIPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE 

       430        440        450        460        470        480 
DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFFQMID ESQSLSLCGM 

       490        500        510        520        530        540 
VWEHRKGTDY HKQPWQAKIS VTRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS 

       550        560        570        580        590        600 
VGGKKQDLEI EEVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLNYRQ TIRPICLPCT 

       610        620        630        640        650        660 
EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA 

       670        680        690        700        710        720 
QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG 

       730        740        750        760 
VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKQKLQDED LGFL

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References

[1]"Comparative analysis of human and primate complement C2 and factor B genes."
Schneider P.M., Tantalaki E., Stradmann-Bellinghausen B., Rittner C.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY074662 Genomic DNA. Translation: AAM10003.1.

3D structure databases

ProteinModelPortalQ864W1.
SMRQ864W1. Positions 34-764.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ864W1.

Protein family/group databases

MEROPSS01.196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

GeneTreeENSGT00530000063826.
HOVERGENHBG002567.
InParanoidQ864W1.

Family and domain databases

InterProIPR011360. Compl_C2_B.
IPR016060. Complement_control_module.
IPR009003. Pept_cys/ser_Trypsin-like.
IPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP.
IPR002035. VWF_A.
[Graphical view]
Gene3DG3DSA:2.10.70.10. Complement_control_module. 2 hits.
PfamPF00084. Sushi. 3 hits.
PF00089. Trypsin. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFPIRSF001154. Compl_C2_B. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00032. CCP. 3 hits.
SM00020. Tryp_SPc. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF57535. Complement_control_module. 3 hits.
SSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50923. SUSHI. 3 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCFAB_PONPY
AccessionPrimary (citable) accession number: Q864W1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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