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Protein

Interleukin-13

Gene

IL13

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000004586019 – 132Interleukin-13Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi48 ↔ 76By similarity
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi64 ↔ 90By similarity
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ864V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006140.
InParanoidiQ864V6.
KOiK05435.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q864V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLTTVIA LTCLGGFASP SPVPRSTALK ELIEELVNIT QNQKAPLCNG
60 70 80 90 100
SMVWSINLTA GVYCAALESL INVSGCSAIE KTQRMLNGFC PHKVSAGQFS
110 120 130
SLRVRDTKIE VAQFVKDLLV HLKKLFREGR FN
Length:132
Mass (Da):14,380
Last modified:June 1, 2003 - v1
Checksum:iF91E05B7B8E5EA53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY244790 mRNA. Translation: AAO89232.1.
RefSeqiNP_001028101.1. NM_001032929.1.
UniGeneiMmu.3675.

Genome annotation databases

GeneIDi574325.
KEGGimcc:574325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY244790 mRNA. Translation: AAO89232.1.
RefSeqiNP_001028101.1. NM_001032929.1.
UniGeneiMmu.3675.

3D structure databases

ProteinModelPortaliQ864V6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574325.
KEGGimcc:574325.

Organism-specific databases

CTDi3596.

Phylogenomic databases

HOVERGENiHBG006140.
InParanoidiQ864V6.
KOiK05435.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11322. PTHR11322. 1 hit.
PfamiPF03487. IL13. 1 hit.
[Graphical view]
PRINTSiPR01929. INTRLEUKIN13.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL13_MACMU
AccessioniPrimary (citable) accession number: Q864V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.