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Q864U6 (B3GL1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Short name=Beta-1,3-GalNAc-T1
EC=2.4.1.79
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name=Beta-1,3-GalTase 3
Short name=Beta3Gal-T3
Short name=Beta3GalT3
Short name=b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene names
Name:B3GALNT1
Synonyms:B3GALT3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers N-acetylgalactosamine onto globotriaosylceramide By similarity.

Catalytic activity

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Cofactor

Magnesium By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
PRO_0000219156

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain44 – 331288Lumenal Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q864U6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 3686FB95DA581CE3

FASTA33139,437
        10         20         30         40         50         60 
MAPALPITLP SKMSLRSLKW SLLLLSLLSF LVMWYLSLPH YNVIERVNWM YFYEYEPIYR 

        70         80         90        100        110        120 
QDFHFTLREH SNCSHQNPFL VILVTSHPAD VKARQAIRVT WGEKKSWWGY EVLTFFLLGQ 

       130        140        150        160        170        180 
QAEREDKVLA LSLEDEHLLY GDIIRQDFLD TYNNLTLKTI MAFRWVTEFC PNARYIMKTD 

       190        200        210        220        230        240 
TDVFINTGNL VKYLLNLNHS EKFFTGYPLI DNYSYRGFYQ KTHISYQEYP FKVFPPYCSG 

       250        260        270        280        290        300 
LGYIMSRDLV PRIYEMMSHV KPIKFEDVYV GICLNLLKVD IHIPEDTNLF FLYRIHLDVC 

       310        320        330 
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y 

« Hide

References

[1]Python P., Joerg H., Neuenschwander S., Stranzinger G., Voegeli P.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY253340 mRNA. Translation: AAO92025.1.
RefSeqNP_999516.1. NM_214351.1.
XP_005652470.1. XM_005652413.1.
UniGeneSsc.13482.

3D structure databases

ProteinModelPortalQ864U6.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000026210; ENSSSCP00000023800; ENSSSCG00000021774.
GeneID397634.
KEGGssc:397634.

Organism-specific databases

CTD8706.

Phylogenomic databases

GeneTreeENSGT00740000114871.
HOVERGENHBG101817.
KOK00719.
OMACPNAKYI.
OrthoDBEOG7M3J0F.
TreeFamTF318639.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERPTHR11214. PTHR11214. 1 hit.
PfamPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3GL1_PIG
AccessionPrimary (citable) accession number: Q864U6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways