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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1327 – 1334ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 316CytoplasmicBy similarityAdd BLAST123
Transmembranei317 – 337Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini338 – 363ExtracellularBy similarityAdd BLAST26
Transmembranei364 – 384Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini385 – 440CytoplasmicBy similarityAdd BLAST56
Transmembranei441 – 461Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini462 – 464ExtracellularBy similarity3
Transmembranei465 – 485Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini486 – 547CytoplasmicBy similarityAdd BLAST62
Transmembranei548 – 568Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini569 – 590ExtracellularBy similarityAdd BLAST22
Transmembranei591 – 611Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini612 – 967CytoplasmicBy similarityAdd BLAST356
Transmembranei968 – 988Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini989 – 1025ExtracellularBy similarityAdd BLAST37
Transmembranei1026 – 1046Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1047 – 1089CytoplasmicBy similarityAdd BLAST43
Transmembranei1090 – 1110Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1111ExtracellularBy similarity1
Transmembranei1112 – 1132Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1133 – 1203CytoplasmicBy similarityAdd BLAST71
Transmembranei1204 – 1224Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1225 – 1226ExtracellularBy similarity2
Transmembranei1227 – 1247Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1248 – 1531CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933521 – 1531Multidrug resistance-associated protein 1Add BLAST1531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei905PhosphoserineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei930PhosphoserineBy similarity1
Glycosylationi1006N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ864R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1256ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1293 – 1527ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108314.
KOiK05665.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q864R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRGFCSAD GSDPLWDWNV TWYTSNPDFT KCFQNTVLVW VPCFYLWACF
60 70 80 90 100
PFYFLYLSRH DRGYIQMTLL NKTKTALGFL LWIVCWADLF YSFWERSRGI
110 120 130 140 150
FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL
160 170 180 190 200
AILRSKIMTA LKEDVQVDLF RDMTFYVYFS LVLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKDSSK VDANEEVEAL
310 320 330 340 350
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPEILKLLI
360 370 380 390 400
NFVNDTKAPD WQGYFYTALL FVAACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNAARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWR NLGPPILAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLAAVGT
560 570 580 590 600
FTWVCTPFLV ALCTFAVYVT IDKNNVLDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGD TNSITVRNAT
660 670 680 690 700
FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVALKGSVAY VPQQAWIQND SLQENILFGC QLEEPYYRSV IQACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYCNADIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA SAEQEQDPED NGVTGVSGPG KEAKQMENGM
910 920 930 940 950
LVTDSAGKQL QRQLSSSSSY SGDVSRQHNS TAELQKDGAK KEETWKLMEA
960 970 980 990 1000
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFICNHVAAL ASNYWLSLWT
1010 1020 1030 1040 1050
DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV
1060 1070 1080 1090 1100
DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN
1110 1120 1130 1140 1150
VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP
1160 1170 1180 1190 1200
VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM
1260 1270 1280 1290 1300
SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSNWPQV GRVEFRNYCL
1310 1320 1330 1340 1350
RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE
1360 1370 1380 1390 1400
IIIDGINIAR IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW
1410 1420 1430 1440 1450
TSLELAHLKG FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI
1460 1470 1480 1490 1500
LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIQEYGA PSDLLQQRGL FYNMARDAGL V
Length:1,531
Mass (Da):171,659
Last modified:June 1, 2003 - v1
Checksum:i1AE788EFDF9EF459
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti173M → I.1 Publication1
Natural varianti704L → I.1 Publication1
Natural varianti1047C → Y.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146672 mRNA. Translation: AAN65348.1.
AY146673 mRNA. Translation: AAN65349.1.
RefSeqiNP_001271100.1. NM_001284171.1.

Genome annotation databases

GeneIDi102133648.
KEGGimcf:102133648.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146672 mRNA. Translation: AAN65348.1.
AY146673 mRNA. Translation: AAN65349.1.
RefSeqiNP_001271100.1. NM_001284171.1.

3D structure databases

ProteinModelPortaliQ864R9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102133648.
KEGGimcf:102133648.

Organism-specific databases

CTDi4363.

Phylogenomic databases

HOVERGENiHBG108314.
KOiK05665.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP1_MACFA
AccessioniPrimary (citable) accession number: Q864R9
Secondary accession number(s): Q864S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2003
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.