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Protein

Melanocyte-stimulating hormone receptor

Gene

MC1R

Organism
Saguinus fuscicollis (Brown-headed tamarin)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocyte-stimulating hormone receptor
Short name:
MSH-R
Alternative name(s):
Melanocortin receptor 1
Short name:
MC1-R
Gene namesi
Name:MC1R
OrganismiSaguinus fuscicollis (Brown-headed tamarin)
Taxonomic identifieri9487 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeSaguinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 63Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini64 – 72CytoplasmicSequence analysis9
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 118ExtracellularSequence analysisAdd BLAST25
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini141 – 163CytoplasmicSequence analysisAdd BLAST23
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 191ExtracellularSequence analysis8
Transmembranei192 – 211Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 266Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini267 – 279ExtracellularSequence analysisAdd BLAST13
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 316CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698441 – 316Melanocyte-stimulating hormone receptorAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi314S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ864H4
SMRiQ864H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108148

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
IPR000761 MSH_rcpt
PANTHERiPTHR22750:SF2 PTHR22750:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00536 MELNOCYTESHR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q864H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMQGAHRKL LGSLNSTPTA TSNLGLAANH TGAPCLEVSI PDGLFLSLGL
60 70 80 90 100
VSLVENVLVV AAIAKNRNLH SSMYCFICCL ALSDLLVSGS NMLETAVILL
110 120 130 140 150
LEAGALATRT SVVQQLHNTI DVLTCSSMLC SLCFLGAIAV DRYISIFYAL
160 170 180 190 200
RYHSIMTLPR AQRAIAAIWV ASVLSSTLFI TYYDHAAVLL CLVVFFLAML
210 220 230 240 250
VLMAVLYVHM LARACQHAHG IIRLHKRQSP AHQGFGLRGA ATLTILLGIF
260 270 280 290 300
FLCWGPFFLH LTLVVFCPQH LTCSCIFKNF KVFLTLIICN TIIDPLIYAF
310
RSQELRRTLK EVLCSW
Length:316
Mass (Da):34,718
Last modified:June 1, 2003 - v1
Checksum:i0DF5B06683165030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY205123 Genomic DNA Translation: AAP30997.1

Similar proteinsi

Entry informationi

Entry nameiMSHR_SAGFU
AccessioniPrimary (citable) accession number: Q864H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health