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Protein

Interleukin-4 receptor subunit alpha

Gene

IL4R

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4 receptor subunit alpha
Short name:
IL-4 receptor subunit alpha
Short name:
IL-4R subunit alpha
Short name:
IL-4R-alpha
Short name:
IL-4RA
Alternative name(s):
CD_antigen: CD124
Gene namesi
Name:IL4R
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 240208ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26424HelicalSequence analysisAdd
BLAST
Topological domaini265 – 830566CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 830798Interleukin-4 receptor subunit alphaPRO_0000010891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 51By similarity
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi82 ↔ 94By similarity
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Modified residuei172 – 1721PhosphoserineBy similarity
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Modified residuei504 – 5041PhosphotyrosineBy similarity

Post-translational modificationi

On IL4 binding, phosphorylated on C-terminal tyrosine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ863Z5.

Expressioni

Gene expression databases

BgeeiENSSSCG00000007817.
GenevisibleiQ863Z5. SS.

Interactioni

Subunit structurei

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008346.

Structurei

3D structure databases

ProteinModelPortaliQ863Z5.
SMRiQ863Z5. Positions 34-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 232100Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni444 – 564121Required for IRS1 activation and IL4-induced cell growthBy similarityAdd
BLAST
Regioni564 – 66299Required for IL4-induced gene expressionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi220 – 2245WSXWS motif
Motifi270 – 2789Box 1 motif
Motifi716 – 7216ITIM motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi378 – 3869Glu-rich

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGBQ. Eukaryota.
ENOG41124QC. LUCA.
HOVERGENiHBG052116.
InParanoidiQ863Z5.
KOiK05071.
OrthoDBiEOG091G010H.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015319. IL-4_rcpt-alpha_N.
[Graphical view]
PfamiPF09238. IL4Ra_N. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q863Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLCPGLTF SVSCLILVWA AGSGVTCVSP GGVRVLEWPI CLSDYVSTST
60 70 80 90 100
CEWRMAGPVN CSAEFRLSYQ LKFFNTENHT TCVPENRAGS VCVCHMLMES
110 120 130 140 150
IVIVDTYQLD LWAGEQLLWN SSFKPSQNVK PLAPRNLMVH ANISHTWLLT
160 170 180 190 200
WSNPYPSESY LYSELTYLVN ISNENDPTDF RIYNVTYLGP TLRFPANTLK
210 220 230 240 250
SGAAYSARVK AWAQRYNSTW SEWSPSVKWL NYYEEPLEQR LPLGVSISCV
260 270 280 290 300
VILIICLSCY FGIIRIKKEW WDQIPNPAHS PLVAIVIQDS QVSLWGKRSR
310 320 330 340 350
GQEPAKCPRW KTCLTKLLPC FLEHGVDRDE DSSKAARNGP SQGPAKAAWR
360 370 380 390 400
PVEVSKTILW PESISVVRCV ELFEAQVENE EEEEEEDKGS FCPSPENSGG
410 420 430 440 450
SFQEGREGIA ARLTESLFLD LLGDESGAFS PQGMGQSCLL PPLENASAPM
460 470 480 490 500
PWAEFPRVGS PEASSQGKEQ PLNPEPSPQA TPTQSLASLA FPELPAVIAD
510 520 530 540 550
NPAYRSFSTF LSQSSDPGEL DSDPELAEAL EEVEPSLPAA PQPSEPPPTL
560 570 580 590 600
QPEPETWEQI LRQSVLQRRA APAPASGPSS SGYREFVHAV EQGTQDRRAA
610 620 630 640 650
GSGPCGEAGY KAFSSLLAGS ASCPGTSGLE PSSGESGYKP FQSLPPGCPE
660 670 680 690 700
TPVPTPLFTF GLDMEPPPSP QNPPFPGSSA ECPGLEPAVK GEDGQKPPLA
710 720 730 740 750
LEQAADPLRD DLGSGIVYSA LTCHLCGHLK QCHGQEDGGK VHVVASPCCS
760 770 780 790 800
CCCEDGSPPM VTPLRAPDAP SSGVPLEASL SPASLALLGV SREGKIPPCL
810 820 830
QITPSNVQSS SQTPTAVAML SPGPACMDTS
Length:830
Mass (Da):89,441
Last modified:June 1, 2003 - v1
Checksum:i22EB899AE87B1683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266143 mRNA. Translation: AAP23302.1.
RefSeqiNP_999505.1. NM_214340.1.
UniGeneiSsc.17244.

Genome annotation databases

GeneIDi397614.
KEGGissc:397614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266143 mRNA. Translation: AAP23302.1.
RefSeqiNP_999505.1. NM_214340.1.
UniGeneiSsc.17244.

3D structure databases

ProteinModelPortaliQ863Z5.
SMRiQ863Z5. Positions 34-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008346.

Proteomic databases

PaxDbiQ863Z5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397614.
KEGGissc:397614.

Organism-specific databases

CTDi3566.

Phylogenomic databases

eggNOGiENOG410IGBQ. Eukaryota.
ENOG41124QC. LUCA.
HOVERGENiHBG052116.
InParanoidiQ863Z5.
KOiK05071.
OrthoDBiEOG091G010H.

Gene expression databases

BgeeiENSSSCG00000007817.
GenevisibleiQ863Z5. SS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015319. IL-4_rcpt-alpha_N.
[Graphical view]
PfamiPF09238. IL4Ra_N. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL4RA_PIG
AccessioniPrimary (citable) accession number: Q863Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.