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Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:PSME2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001617872 – 239Proteasome activator complex subunit 2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ863Z0.
PeptideAtlasiQ863Z0.
PRIDEiQ863Z0.

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002190.

Structurei

3D structure databases

ProteinModelPortaliQ863Z0.
SMRiQ863Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiKOG4470. Eukaryota.
ENOG410XQVX. LUCA.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
InParanoidiQ863Z0.
KOiK06697.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiView protein in InterPro
IPR003186. PA28_C.
IPR036997. PA28_C_sf.
IPR036996. PA28_N_sf.
IPR009077. Proteasome_activ_PA28.
IPR003185. Proteasome_activ_PA28_N.
IPR036252. Proteasome_activ_sf.
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiView protein in Pfam
PF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
SUPFAMiSSF47216. SSF47216. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q863Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPCGVRLS GEARKQVDVF RQNLFQEAEE FLYRFLPQKI IYLSQLLQED
60 70 80 90 100
SLNVTDLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKI
110 120 130 140 150
LALLGLVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AVQEKVLERV
160 170 180 190 200
NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAHG
210 220 230
ELRAMVLDLR AFYAELYHII SSNLEKIVDP KGEEKPSMY
Length:239
Mass (Da):27,296
Last modified:January 23, 2007 - v3
Checksum:i42569D600F90E963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527991 mRNA. Translation: AAP30879.1.
AY317125 Genomic DNA. Translation: AAQ83575.1.
RefSeqiNP_999444.1. NM_214279.1.
UniGeneiSsc.830.

Genome annotation databases

GeneIDi397522.
KEGGissc:397522.

Similar proteinsi

Entry informationi

Entry nameiPSME2_PIG
AccessioniPrimary (citable) accession number: Q863Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families