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Protein

Serine/threonine-protein kinase OSR1

Gene

OXSR1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

By autophosphorylation on threonine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPPROSITE-ProRule annotationBy similarity
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 319ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)
Alternative name(s):
Oxidative stress-responsive 1 protein
Gene namesi
Name:OXSR1By similarity
Synonyms:OSR1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 529528Serine/threonine-protein kinase OSR1PRO_0000086458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei347 – 3471PhosphoserineBy similarity
Modified residuei429 – 4291PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ863I2.
PRIDEiQ863I2.

Interactioni

Subunit structurei

Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011997.

Structurei

3D structure databases

ProteinModelPortaliQ863I2.
SMRiQ863I2. Positions 6-298, 435-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 291275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiQ863I2.
KOiK08835.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q863I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDSSALPW SINKDDYELQ EVIGSGATAV VQAAYCTPKK EKVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE ATIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEYL
310 320 330 340 350
QEKILQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
KAAISQLRSP RVKESLTNSE LFSTTHPVGT LLQVPEQISA HLPQSAGQMP
410 420 430 440 450
AQLTPVSLPP AAELAPVQAA QAQSSGAGSQ ETKIPISLVL RLRNSKKELN
460 470 480 490 500
DIRFEFTPGR DTAEGVSQEL ISAGLVDGRD LVIVAANLQK IVEEPQSNRS
510 520
VTFKLASGVE GSDIPDDSKL IGFAQLSIS
Length:529
Mass (Da):58,233
Last modified:June 1, 2003 - v1
Checksum:i3B93703147C5E963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271356 mRNA. Translation: AAP32466.1.
RefSeqiNP_001302601.1. NM_001315672.1.
NP_999507.1. NM_214342.1.
UniGeneiSsc.94482.

Genome annotation databases

GeneIDi106505565.
397618.
KEGGissc:397618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271356 mRNA. Translation: AAP32466.1.
RefSeqiNP_001302601.1. NM_001315672.1.
NP_999507.1. NM_214342.1.
UniGeneiSsc.94482.

3D structure databases

ProteinModelPortaliQ863I2.
SMRiQ863I2. Positions 6-298, 435-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011997.

Proteomic databases

PaxDbiQ863I2.
PRIDEiQ863I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106505565.
397618.
KEGGissc:397618.

Organism-specific databases

CTDi9943.

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiQ863I2.
KOiK08835.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The novel molecule porcine OSR1 up-regulated expression on porcine endothelial cell by human peripheral blood mononuclear cell activation."
    Hu W., Cheng J., Lu X., Li S., Zeng L., Li Y.
    Transplant. Proc. 36:2475-2477(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiOXSR1_PIG
AccessioniPrimary (citable) accession number: Q863I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.