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Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  • fibronectin binding Source: BHF-UCL
  • G-protein coupled receptor activity Source: GO_Central
  • integrin binding Source: BHF-UCL
  • Wnt-activated receptor activity Source: GO_Central
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Gene namesi
Name:SFRP2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003254125 – 294Secreted frizzled-related protein 2Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 102By similarity
Disulfide bondi49 ↔ 95By similarity
Disulfide bondi86 ↔ 124By similarity
Disulfide bondi113 ↔ 151By similarity
Disulfide bondi117 ↔ 141By similarity
Disulfide bondi171 ↔ 244By similarity
Disulfide bondi174 ↔ 246By similarity
Disulfide bondi189 ↔ 294By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ863H1.

Expressioni

Inductioni

Up-regulated in mammary gland tumors.

Interactioni

GO - Molecular functioni

  • fibronectin binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • Wnt-protein binding Source: GO_Central

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012270.

Structurei

3D structure databases

ProteinModelPortaliQ863H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 154FZPROSITE-ProRule annotationAdd BLAST121
Domaini171 – 294NTRPROSITE-ProRule annotationAdd BLAST124

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG052928.
InParanoidiQ863H1.
KOiK02176.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q863H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGPGSLLL LVLASHCCLG SARGLFFGQP DFSYKRSNCK PIPANLQLCH
60 70 80 90 100
GIEYQNMRLP NLLGHETMKE VLEQAGAWIP LVMKQCHPDT KKFLCSLFAP
110 120 130 140 150
VCLDDLDETI QPCHSLCVQV KDRCAPVMSA FGFPWPDMLE CDRFPQDNDL
160 170 180 190 200
CIPLASSDHL LPATEEAPKV CEACKNKNED DNDIMETLCK NDFALKIKVK
210 220 230 240 250
EITYINRDTK IILETKSKTI YKLNGVSERD LKKSVLWLKD SLQCTCEEMN
260 270 280 290
DINAPYLVMG QKLGGELVIT SVKRWQKGQR EFKRISRSIR KLQC
Length:294
Mass (Da):33,340
Last modified:June 1, 2003 - v1
Checksum:i79C1FF3882CBE1B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560716 mRNA. Translation: CAD90762.1.
RefSeqiNP_001002987.1. NM_001002987.2.
UniGeneiCfa.1200.

Genome annotation databases

GeneIDi475471.
KEGGicfa:475471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560716 mRNA. Translation: CAD90762.1.
RefSeqiNP_001002987.1. NM_001002987.2.
UniGeneiCfa.1200.

3D structure databases

ProteinModelPortaliQ863H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000012270.

Protein family/group databases

MEROPSiI93.002.

Proteomic databases

PaxDbiQ863H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi475471.
KEGGicfa:475471.

Organism-specific databases

CTDi6423.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG052928.
InParanoidiQ863H1.
KOiK02176.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFRP2_CANLF
AccessioniPrimary (citable) accession number: Q863H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.