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Protein

T-box transcription factor TBX2

Gene

TBX2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi109 – 287T-boxPROSITE-ProRule annotationAdd BLAST179

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX2
Short name:
T-box protein 2
Gene namesi
Name:TBX2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844251 – 712T-box transcription factor TBX2Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei653PhosphoserineBy similarity1
Modified residuei657PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ863A2.

Interactioni

Subunit structurei

Interacts with PML.By similarity

Structurei

3D structure databases

SMRiQ863A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni517 – 601Repression domain 1 (RD1)By similarityAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 87Ala-richAdd BLAST60
Compositional biasi460 – 538Gly-richAdd BLAST79
Compositional biasi581 – 603Ala-richAdd BLAST23

Domaini

The repression domain 1 (RD1) is necessary for its interaction with PML.By similarity

Phylogenomic databases

HOVERGENiHBG000412.
InParanoidiQ863A2.

Family and domain databases

CDDicd00182. TBOX. 1 hit.
Gene3Di2.60.40.820. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR036960. T-box_sf.
IPR022582. TBX.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiView protein in Pfam
PF00907. T-box. 1 hit.
PF12598. TBX. 1 hit.
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiView protein in SMART
SM00425. TBOX. 1 hit.
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q863A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK
60 70 80 90 100
PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE
110 120 130 140 150
VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK
160 170 180 190 200
YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM
210 220 230 240 250
AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
260 270 280 290 300
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT
310 320 330 340 350
LPSLRLYEEH CKPERDGAES DASSCDPAPA REPPASPGSA PSPLRLHRTR
360 370 380 390 400
ADEKCAADSD PEPERLSEER AGPALGRSPG LDGGSPPRLT EPERARERRS
410 420 430 440 450
PERGKEPAES GGDGPFGLRS LEKERAEARR KDDGRKEAGE GKEPGLAPLV
460 470 480 490 500
VQTDSASPLG AGHLPGLAFS GHLHGQQFFG PLGAGQPLFL HPGQFAMGPG
510 520 530 540 550
AFSAMGMGHL LASVAGGGGG GGGGGPGTAT GLDAGGLGPA ASAASTPAPF
560 570 580 590 600
PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA
610 620 630 640 650
AAAGSLSRSH FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LAAEGSKAAG
660 670 680 690 700
SNSREPSPLP ELALRKVGAP SRGALSPSGS AKEAASELQS IQRLVSGLEN
710
QRALSPGRES PK
Length:712
Mass (Da):74,900
Last modified:April 20, 2010 - v2
Checksum:iA8AC367FE34AE025
GO

Sequence cautioni

Q863A2: The sequence AAO24699 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192802
, AY192798, AY192799, AY192800, AY192801 Genomic DNA. Translation: AAO24699.1. Different initiation.
UniGeneiCfa.16322.

Similar proteinsi

Entry informationi

Entry nameiTBX2_CANLF
AccessioniPrimary (citable) accession number: Q863A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome