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Q86341

- VP6_ROTA1

UniProt

Q86341 - VP6_ROTA1

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus A (strain Turkey/Ireland/Ty-1/1978 G7-P[17]-I4-Rx-Cx-Mx-Ax-N4-Tx-E4-Hx) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi153 – 1531Zinc; shared with all trimeric partnersBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus A (strain Turkey/Ireland/Ty-1/1978 G7-P[17]-I4-Rx-Cx-Mx-Ax-N4-Tx-E4-Hx) (RV-A)
    Taxonomic identifieri12584 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiAves [TaxID: 8782]

    Subcellular locationi

    Virion
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.By similarity

    GO - Cellular componenti

    1. viral envelope Source: InterPro
    2. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Intermediate capsid protein VP6PRO_0000368185Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.By similarity

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ86341.
    SMRiQ86341. Positions 1-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view]
    PfamiPF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view]
    ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q86341-1 [UniParc]FASTAAdd to Basket

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    MDVLYSLAKT LKDARARIVE GTLYTNVADI VQQVNQVINS INGSTFQTGG    50
    IGNLPIRNWT FDFGTLGTTL LNLDANYVEN ARTTIDYFID FVDSVCVDEI 100
    VRESQRNGIA PQSDSLRQLS NAKYKRINYD NESEYIENWN LQNRRQRTGY 150
    LLHKPNILPY NNSFTLTRSQ PAHDNVCGTI WLNNGSEIEI AGFDSECALN 200
    APGNIQEFEH VVPMRRVLNN ATVSLLPYAP RLTQRAVIPT ADGLNTWLFN 250
    PIILRPNNVQ VEFLLNGQVI TNYQARYGIL AARNFDSIRI SFQLVRPPNM 300
    TPGVAALFPV AAPFPNHATV GLTLKIESAS CESVLSDANE PYLSIVTGLR 350
    QEYAIPVGPV FPAGMNWTEL LNNYSASRED NLQRIFTAAS IRSMIIK 397
    Length:397
    Mass (Da):44,378
    Last modified:November 1, 1996 - v1
    Checksum:iBF05BCD715605896
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82980 Genomic RNA. Translation: BAA11668.1.
    X98871 mRNA. Translation: CAD88598.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82980 Genomic RNA. Translation: BAA11668.1 .
    X98871 mRNA. Translation: CAD88598.1 .

    3D structure databases

    ProteinModelPortali Q86341.
    SMRi Q86341. Positions 1-397.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view ]
    Pfami PF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view ]
    ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the VP6 gene in group A turkey and chicken rotaviruses."
      Ito H., Minamoto N., Hiraga S., Sugiyama M.
      Virus Res. 47:79-83(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Rohwedder A., Hotop H., Bruessow H.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVP6_ROTA1
    AccessioniPrimary (citable) accession number: Q86341
    Secondary accession number(s): Q80GJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases By similarity.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3